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Morbidity and Mortality in Adults with Undiagnosed Celiac Disease


Photo: Gastroenterology

Celiac.com 08/18/2010 - The importance of an accurate celiac disease diagnosis is becoming increasingly more evident to health practitioners and the general public worldwide. While the outcomes of undiagnosed celiac disease are still unclear, current  studies are attempting to find an answer.

Between 1995 and 2001, serum samples were obtained from 16,886 Olmsted County, Minnesota citizens 50 years of age or older with unknown celiac status.

Out of 16,847 adults studied, 129 cases were discovered to have undiagnosed celiac disease. 127 undiagnosed celiacs and 254 unmatched controls were then submitted for a systematic evaluation in search of over 100 possibly coexisting ailments.

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The scientists found that while celiac disease has been associated with an elevated risk for cancer, this study found no significant risk increase for cancer in undiagnosed celiacs compared to the control group.

Researchers also found that those patients with undiagnosed celiac disease displayed an increased rate of osteoporosis and hypothyroidism. Furthermore, undiagnosed celiacs were also found to typically have a lower body mass index, and lower levels of ferritin and cholesterol, and to be less prone to arthritis and have a reduced rate of glucose intolerance. The correlation between lower arthritis and glucose intolerance in undiagnosed celiacs is speculated to be a result of a lower body mass index. 

In conclusion, researchers were not able to determine a connection between undiagnosed celiac in older adults and comorbidity. In fact, except for impaired bone health, most undiagnosed celiacs in this study displayed little comorbidity and they did not have increased mortality rates when compared to the control group.

Researchers of this study therefore concluded that there may be advantages and disadvantages to being an older undiagnosed celiac.

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5 Responses:

 
Sarah Bosse
Rating: ratingfullratingfullratingfullratingemptyratingempty Unrated
said this on
18 Aug 2010 5:15:55 PM PDT
"Researchers of this study therefore concluded that there may be advantages and disadvantages to being an older undiagnosed celiac."

I'd like to know...what the Heck could be an ADVANTAGE to being an older undiagnosed celiac????? Wow.

Otherwise, ok article.

 
Ed Yellin
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said this on
23 Aug 2010 12:50:23 PM PDT
Good question. I haven't read the original article, but off the top of my head, perhaps those who are undiagnosed had no symptoms and that's why they weren't diagnosed. So the next question is what were the diagnostic tests?

 
Crystal
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said this on
24 Aug 2010 10:10:07 AM PDT
Furthermore, undiagnosed celiacs were also found to typically have a lower body mass index, and lower levels of ferritin and cholesterol, and to be less prone to arthritis and have a reduced rate of glucose intolerance.

I believe these are the advantages they are speaking of.

 
Mary
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said this on
02 Sep 2010 11:26:05 AM PDT
re: lower body mass index
I assume they mean the people walking around who look like a skeleton. That's how I looked before I was diagnosed with celiac.

 
Mario
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said this on
24 Apr 2013 8:24:19 AM PDT
I'm making these right now and I forgot to add the brown sugar before I put the first tray of them in the oven. I went back and mixed it in (melted it a bit first so it WOULD mix in). The ones without the brown sugar came out nicely-good shape, good size-but didn't taste that great. The next batch became an entire sheet of very flat cookie madness! I had to break them into ugly, but tasty, sections. I only put 8 on the next sheet and they spaced out better but are still very expansive and very, very flat. Is that just because I messed up the ingredients and had to go back and add the brown sugar later? Or is it more likely because I live at 7000 feet?




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...ON a side note this is quite easy, you can make your own out of any gluten-free Bread mix, I recently started using a coconut flour blend for this.......Most often people associate caraway with Rye Bread so you just add caraway seeds to the dough and a bit more vinegar to sour it a tad and BAM gluten-free Rye Bread knock off. I think Authentic Foods even has a additive to put in bread mixes to make it taste like Rye Bread....Or you can buy it preamade, I have issues with all the other ingredients but as for one of the best gluten-free Breads out the Canyon House makes a Rye like bread https://canyonglutenfree.com/buy-gluten-free-bread-products/Gluten-Free-Rye-Deli-Sandwich-Bread.html

Took me less than a minute, although why did they need our addy and phone?

As mentioned before you said she had rashes, have they checked if that is DH? That is a positive sign of celiac and those with the DH manifestation can have problems getting a postive with the gut biopsy. Here are some links. https://celiac.org/celiac-disease/understanding-celiac-disease-2/dermatitis-herpetiformis/ https://www.gluten.org/resources/getting-started/dermatitus-herpetiformis/ Please read up on this. She can get the rash tested for the disease if it is DH.

Thanks for your reply. I will get her retested. She hasn't had any gluten for a year and is very good at not eating it, but had some cake that night. It's so hard because the Dr who did the biopsy said there wasn't any damage so she can't be classed as Coeliacs. She had ten samples taken, but yes, like you say the intestines are huge.

Thank you for your informative reply. Yes I think you are right in that she is still getting dome cross contamination exposure through chopping boards, condiments etc. I will get her bloods redone to see if her levels have dropped and do a gluten challenge again. We all are on a whole foods diet, buy not all Gluten-Free. I find extended family difficult as because she had a negative biopsy they don't believe she could still possibly have it and aren't so careful with her. Thank you for the links, all very helpful.