Jump to content
This site uses cookies. Continued use is acceptance of our Terms of Use and Privacy Policy. More Info... ×
  • Welcome to Celiac.com!

    You have found your celiac tribe! Join us and ask questions in our forum, share your story, and connect with others.




  • Celiac.com Sponsor (A1):



    Celiac.com Sponsor (A1-M):


  • Get Celiac.com Updates:
    Help Celiac.com:
    eNewsletter
    Donate
  • Record is Archived

    This article is now archived and is closed to further replies.

    Jefferson Adams
    Jefferson Adams

    High Levels of Oxidative DNA Damage in Children with Celiac Disease

    Reviewed and edited by a celiac disease expert.
    High Levels of Oxidative DNA Damage in Children with Celiac Disease - New study on DNA damage and celiac disease
    Caption: New study on DNA damage and celiac disease

    Celiac.com 09/20/2010 - People with celiac disease face increased risk of cancer and a large amount of circumstantial evidence suggests that oxidatively damaged DNA may be used to help predict future cancer development in celiac patients.

    To evaluate that hypothesis, a research team set out to assess and describe oxidative stress and oxidative DNA damage in celiac disease patients.

    Celiac.com Sponsor (A12):
    Anna Szaflarska-PopÅ‚awska, Agnieszka Siomek, MieczysÅ‚awa Czerwionka-Szaflarska, Daniel Gackowski, RafaÅ‚ Różalski, Jolanta Guz, Anna Szpila, Ewelina Zarakowska and Ryszard OliÅ„ski comprised the research team. They are associated with the college of medicine at Nicolaus Copernicus University, in Bydgoszcz, Poland.

    They found that children with celiac disease have higher than normal levels of the oxidative DNA damage biomarkers urinary 8-oxodG and 8-oxoGua, regardless of following a gluten-free diet.

    To measure urinary excretion of 8-oxodG and 8-oxoGua, and levels of oxidative DNA damage in the leukocytes, as well as the level of antioxidant vitamins, the team used high-performance liquid chromatography (HPLC) and HPLC/gas chromatography with isotope dilution mass detection.

    They observed parameters for DNA damage in a group of children with untreated celiac disease, in a group of children with celiac disease following a strict gluten-free diet, and in a control group of healthy children.

    They found that the two groups of celiacs showed significantly higher overall levels of 8-oxodG in DNA isolated from the leukocytes and from the urine samples than did the control subjects, without regard to diet. There was no significant difference  between treated and untreated celiacs. That means being on a gluten-free diet offered no protection from oxidative DNA damage for all children with celiac disease.

    One key difference was that the untreated celiac children showed significantly lower levels of retinol and α-tocopherol, vitamin A and E, compared to the treated celiac children. Between group difference of 0.31 and 3.76 µmol/l, respectively, suggests that a gluten-free diet offers some protection against oxidative damage in treated celiacs.

    From the results indicate that oxidative stress and/or oxidatively damaged DNA in celiac patients cannot be explained by diet alone, and that factors independent of diet play an important role.

    Supplemental vitamin A and E in celiac disease patients may help minimize the risk of cancer development.

    Source:

    • Open Original Shared Link


    User Feedback

    Recommended Comments

    Guest CeliBelli

    Posted

    What neither the study abstract, nor this restatement of it, disclose is how long the children had been on the gluten free diet. Had all children in group 'b' been on a gluten free diet since birth? Or had they been diagnosed subsequent to birth, and therefore exposed to gluten for some length of time? In addition, there is no mention of the mothers of these children. If the children were gluten free from birth, were their mothers living gluten free while pregnant?

     

    It seems to me that in order to draw the conclusion that the DNA damage cannot be attributed to diet alone, a study would have to control for these factors. If they want to draw conclusions regarding whether or not diet or something else is at work on the DNA of Celiac children, they would have to use a group of children whose mothers had observed strict gluten free diets throughout pregnancy and who then themselves were on strict gluten free diets from birth.

     

    If they did exercise such strict controls, they do not mention it in their abstract, and Mr. Adams does not probe the study for it. Without such strict controls, the study's conclusion that something other than diet is impacting DNA cannot be considered valid.

    Link to comment
    Share on other sites
    Guest Gloria Brown

    Posted

    The influence of gluten ingested from airborne sources needs to be considered when celiac on gluten free and non-gluten free diets are being studied.

    Link to comment
    Share on other sites
    Guest Clarkie

    More proof that we don't really understand celiac yet. We're only seeing one piece of it (the damage to the stomach and digestion, the autoimmune syndrome). People with celiac are more likely to have problems with yeast overgrowth, heavy metal toxicity, fibromyalgia, etc., even long after they've eliminated all gluten from their diets. I really hope the medical communities will pick up on this and start looking at celiac more holistically.

    Link to comment
    Share on other sites


    Guest
    This is now closed for further comments

  • Get Celiac.com Updates:
    Help Celiac.com:
    Donate
  • About Me

    Jefferson Adams

    Jefferson Adams is Celiac.com's senior writer and Digital Content Director. He earned his B.A. and M.F.A. at Arizona State University. His articles, essays, poems, stories and book reviews have appeared in numerous magazines, journals, and websites, including North American Project, Antioch Review, Caliban, Mississippi Review, Slate, and more. He is the author of more than 2,500 articles on celiac disease. His university coursework includes studies in science, scientific methodology, biology, anatomy, physiology, medicine, logic, and advanced research. He previously devised health and medical content for Colgate, Dove, Pfizer, Sharecare, Walgreens, and more. Jefferson has spoken about celiac disease to the media, including an appearance on the KQED radio show Forum, and is the editor of numerous books, including "Cereal Killers" by Scott Adams and Ron Hoggan, Ed.D.

    >VIEW ALL ARTICLES BY JEFFERSON ADAMS

     


  • Celiac.com Sponsor (A17):
    Celiac.com Sponsor (A17):





    Celiac.com Sponsors (A17-M):




  • Related Articles

    Jefferson Adams
    Celiac.com 03/15/2010 - A team of researchers recently set out to investigate mucosal expression of claudins 2, 3 and 4 in the proximal and distal parts of duodenum in children with celiac disease. The team included Dorottya Nagy Szakál, Hajnalka GyÅ‘rffy, András Arató, Áron Cseh, Kriszta Molnár, Mária Papp, Antal DezsÅ‘fi, and Gábor Veres. They are variously associated with the Department of Pediatrics, and the Department of Pathology at Semmelweis University in Budapest, Hungary, and the Department of Medicine at the University of Debrecen in Debrecen, Hungary.
    Duodenal biopsy is an important tool for properly diagnosing celiac disease. However, the issue of finding the best site for taking biopsy samples that will give the best results for diagnosing celiac disease is still not fu...


    Jefferson Adams
    Celiac.com 07/20/2010 - Anyone who's tried to maintain a gluten-free diet for celiac disease or other reasons can likely tell stories about the difficulties and challenges they face on a regular basis. Still, very little research has been done regarding the psychological and social challenges faced by people with celiac disease who are attempting to follow a gluten-free diet.
    Scientists in India recently conducted just such a study. A research team set out to assess psychological and social challenges faced by Indian children with celiac disease who are attempting to follow a gluten-free diet. The research team included Srikanta Basu, J. C. Chauhan, A. K. Dutta, Praveen Kumar, and Arun Kumar from the Division of Gastroenterology, Department of Pediatrics at Lady Hardinge Medical College...


    Jefferson Adams
    Celiac.com 10/20/2011 - Very little study information exists concerning rates of celiac disease-predisposing, HLA-related genes in Arab populations.
    A research team recently investigated the distribution of HLA-DQ2 and -DQ8 genotypes in Libyan children with celiac disease, and in healthy control subjects.
    The study team included Kamla Alaridaa, Jumma Harownb, Maria Rosaria Di Pierroc, Sandro Dragoc, and Carlo Catassid.
    They are affiliated variously with the Department of Pediatrics, “Omar Al Mukhtar” University, and the El Thoura Hospital in Al Bayda, Libya, the Biodiagene S.r.L., Palermo, Italy, the  Department of Pediatrics of the Università Politecnica delle Marche in Ancona, Italy, and the Center For Celiac Research at the University of Maryland School of Medicine in Ba...


    Jefferson Adams
    Celiac.com 07/21/2014 - The presence of HLA haplotype DR3–DQ2 or DR4–DQ8 is associated with an increased risk of celiac disease. In addition, nearly all children with celiac disease have serum antibodies against tissue transglutaminase (tTG).
    A research team recently set out to determine the risk of celiac disease autoimmunity and celiac disease, by age and by halpotype, in children. The research team included Edwin Liu, M.D., Hye-Seung Lee, Ph.D., Carin A. Aronsson, M.Sc., William A. Hagopian, M.D., Ph.D., Sibylle Koletzko, M.D., Ph.D., Marian J. Rewers, M.D., M.P.H., George S. Eisenbarth, M.D., Ph.D., Polly J. Bingley, M.D., Ezio Bonifacio, Ph.D., Ville Simell, M.Sc., and Daniel Agardh, M.D., Ph.D. for the TEDDY Study Group.
    The team studied 6403 children with HLA haplotype DR3...


  • Recent Activity

    1. - trents replied to Linedancegal's topic in Introduce Yourself / Share Stuff
      4

      25 year biopsy confirmed/ate pizza with no ill effects?

    2. - Moodiefoodie replied to Moodiefoodie's topic in Related Issues & Disorders
      2

      Joint swelling when ill even on gluten-free diet

    3. - knitty kitty replied to Holly15892's topic in Post Diagnosis, Recovery & Treatment of Celiac Disease
      7

      Growth spurt after diagnosis in adulthood

    4. - shadycharacter replied to Linedancegal's topic in Introduce Yourself / Share Stuff
      4

      25 year biopsy confirmed/ate pizza with no ill effects?


  • Celiac.com Sponsor (A19):



  • Member Statistics

    • Total Members
      120,466
    • Most Online (within 30 mins)
      7,748

    CtoThaE
    Newest Member
    CtoThaE
    Joined

  • Celiac.com Sponsor (A20):


  • Forum Statistics

    • Total Topics
      120.2k
    • Total Posts
      1m

  • Celiac.com Sponsor (A22):





  • Celiac.com Sponsor (A21):



  • Popular Now

    • Linedancegal
    • Hannah24
      5
    • jessiemariecar
    • Rhonda H
    • HayleyC123
  • Popular Articles

    • Scott Adams
    • Scott Adams
    • Scott Adams
    • Scott Adams
    • Scott Adams
  • Upcoming Events

×
×
  • Create New...