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New Study Shows Celiac Disease on the Rise, Striking Later in Life


Scientists suspect environmental factors fueling higher celiac disease rates, older patients.

Celiac.com 10/26/2010 - A recent study shows that, since 1974, the rate of celiac disease has doubled every fifteen years, and that celiac rates increase as people grow older, with many developing the disease in their 50s or 60s.

The Center for Celiac Research led the study, which looked at 3,511 volunteers who submitted blood samples in 1974 and 1989, along with updates every two to three years until 2007.

Because researchers in the study surveyed the same people over time, says Mayo Clinic gastroenterologist Dr. Joseph Murray, the study adds weight to the concept that celiac disease can emerge at any age.

The study results also echo those of a 2008 Finnish study that found that elderly people had rates of celiac disease nearly two and a half times higher than the general population.

The fact that celiac disease seems to be increasing among older age groups is significant because, if someone can be gluten-tolerant for 40 or 50 years before developing celiac disease, environmental factors may outweigh genetic causes for the disease, says Alessio Fasano, director of the Center for Celiac Research.

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Fasano says that other unknown environmental changes and changes in "the composition of bacteria in our guts" may be causing gluten autoimmunity to present itself later in life.

Although researchers have identified specific genetic markers for the development of celiac disease, the exact way in which people lose tolerance to gluten remains unknown.

However, it's important to understand that even people who have the genetic markers in question are not fated to develop an autoimmune disease, says Fasano. That's because recent study shows "that environmental factors cause an individual's immune system to lose tolerance to gluten, given the fact that genetics was not a factor in our study since we followed the same individuals over time," he says.

If environmental factors do play a role in celiac disease, then it will be interesting to see if certain areas and regions have high celiac rates that are not due to genetic factors.

More importantly, the research team notes that by identifying the environmental factors behind celiac disease, researchers may lead to better treatment and possible prevention of celiac disease and other autoimmune disorders, including type 1 diabetes, rheumatoid arthritis and multiple sclerosis.


SOURCE:
Annals of Medicine: October 2010, Vol. 42, No. 7 , Pages 530-538
doi:10.3109/07853890.2010.514285


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6 Responses:

 
Celiac
Rating: ratingfullratingfullratingfullratingfullratingfull Unrated
said this on
27 Oct 2010 12:21:35 PM PDT
It's actually fairly common knowledge that celiac is NOT a "genetic" disease anymore than Type 1 diabetes, Rheumatoid Arthritis, Lupus, MS, etc. are. Not everyone born with the genes for these diseases gets them. And other people get them with low risk genes. They are multi-factorial diseases. Generally speaking, autoimmune diseases occur in genetically *susceptible* individuals after exposure to the "perfect storm" of triggers and/or events. In some cases environment may play a larger role than genes, in others it's the opposite. In identical twins (same DNA), both twins only have Celiac 70-80% of the time. In a truly genetic disorder without environmental modifiers (such as cystic fibrosis), BOTH twins will have the disease 100% of the time. And this also dispels the myth that you are "born with" Celiac even if you don't show symptoms until later. Not true for most cases, or at least a subset. Now we need to find out WHY Celiac and other autoimmune diseases are increasing. Gene pools don't change in 50 years, and increased diagnosis doesn't explain this study either. Something in our environment is making those with the genes that *CAN* cause autoimmunity to become sick.

 
Sarah
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said this on
29 Oct 2010 5:51:11 AM PDT
One thing that may be going on is that environmental contaminants can interfere with the gut. There is some preliminary research showing possible effects of contaminants on the gut, but more needs to be done.

 
Jen B.
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said this on
01 Nov 2010 6:06:15 AM PDT
I wonder how much of the increase is a true increase in occurrences or more simply better screening tests. We hear so often about how it took years for many celiac patients to be diagnosed with gluten intolerance.

The data during this transition period to better screening can't be compared directly to data with previous screening methods.

 
sharon
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said this on
01 Nov 2010 9:09:41 PM PDT
I agree as a celiac disease mother with two children diagnosed as celiac disease at 16 years. At 14 both children required an epipen for different allergens. With my second child we watch the disease come and get him, anemia, allergies, rising ttg and then celiac.

We took much of the gluten out of his diet to see if that might prevent the onset but that didn't work. Interestingly, both these children had Kawaski disease as children ( a very rare and sometimes fatal disease). Celiac was a 16th birthday present for both, there is definite trigger.

Research is also showing a similar increase in children diagnosed with ASD. Another disease with a known genetic link and unknown environmental trigger. Twins results similar to that of celiac disease.

 
Geri
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said this on
09 Nov 2010 11:59:54 AM PDT
I am 52 years old. I began having digestive issues about 8 years ago after coming off the Atkins diet which I had been on for 6 months. I was diagnosed with IBS 2 years ago. After reading an article about celiac disease, I began to wonder. My female doctor ran a blood test after I consulted with him and he tells me I have a lot of gluten antibodies in my blood as well as thyroiditis. I am going gluten free for about 2 months but still having some issues.

 
clifford cline
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said this on
15 Aug 2012 2:32:03 PM PDT
I enjoyed the info. I am 80 years old. 5 years ago they found I had celiac disease. I have been close to death off and on every since. I went gluten-free 3 years ago (which is hard to do). I have 2 girls and 2 grandsons that have it also, and 2 granddaughters who do not. I wish there was something I could do to help stop it.




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MelissaNZ, Has your daughter been checked for vitamin deficiencies??? Vitamin D deficiency symptoms include urinary incontinence, oral candidiasis (thrush), skin rashes, bumps on the backs of arms, joint pain, distended stomach and short stature. Bones can't grow much without vitamin D. Vitamin D deficiency causes delayed gastric emptying (food doesn't move through the gastrointestinal tract at a normal speed and the intestines bloat) which explains your daughter's delayed reaction to the cake. Vitamin A deficiency is also a cause of bumps on the back of the arms. Vitamin A deficiency causes vision problems. Vitamin A and D are both fat soluble vitamins. Absorption of fats is a problem for Celiacs. So is absorption of B vitamins and important minerals. B Complex vitamins are water soluble and must be replenished every day. Skin rashes are associated with several B vitamins like niacin (B3), B12, and thiamine (B1). I went through a period of severe malnutrition prior to diagnosis. It was not a pleasant experience. I had symptoms similar to your daughter's, including the incontinence, which resolved on vitamin D supplementation. Please, please have your daughter tested for vitamin D deficiency. And have her B vitamins checked as well. Celiac Disease causes malabsorption. Malabsorption causes deficiency diseases. Newly diagnosed Celiacs need to be checked for deficiencies. I hope this helps.

I will try to make my long story short, I have been searching my whole life for a diagnosis, I have seen pretty much every doctor possible I even went through a spinal tap recently because they thought I had multiple sclerosis, when I was younger I was always throwing up and having stomach problems, a couple hospital visits they thought I had appendicitis, I started having a neurological symptoms as well as anxiety and depression, The fatigue was just over bearing, I was having numbness and tingling and muscle spasms all the time eventually started having seizures, which kind of cycled through and stop happening after a couple months, and then it dawned upon me my brother has celiac pretty severely, my grandmother also has celiac, my dad does as well, I don't know why I never thought that it could be my issue, for the last week I have Been gluten-free and steering clear of cross-contamination, my dizziness is improved my fatigue is improved as well as rashes I was getting on my arms and sides, I have no more muscle jerks or spasms, The problem is I have horrible insurance and I cannot afford testing, so I am at least trying to do it an home blood test, I know it's not very accurate on telling me if I have celiac or not, But the thought I may never know for sure if I have it is very daunting. My family keeps telling me you don't need to spend thousands of dollars to have a doctor tell you you can't eat something you already know you can't. Just was wondering if anybody else has been in my position and seeing if anybody has a vi just was wondering if anybody else has been in my position and seeing if anybody has advice, I don't want to be known as one of those people who believe they have something and people with the disease frown upon them it's a very scary thing to think about.

...ON a side note this is quite easy, you can make your own out of any gluten-free Bread mix, I recently started using a coconut flour blend for this.......Most often people associate caraway with Rye Bread so you just add caraway seeds to the dough and a bit more vinegar to sour it a tad and BAM gluten-free Rye Bread knock off. I think Authentic Foods even has a additive to put in bread mixes to make it taste like Rye Bread....Or you can buy it preamade, I have issues with all the other ingredients but as for one of the best gluten-free Breads out the Canyon House makes a Rye like bread https://canyonglutenfree.com/buy-gluten-free-bread-products/Gluten-Free-Rye-Deli-Sandwich-Bread.html

Took me less than a minute, although why did they need our addy and phone?

As mentioned before you said she had rashes, have they checked if that is DH? That is a positive sign of celiac and those with the DH manifestation can have problems getting a postive with the gut biopsy. Here are some links. https://celiac.org/celiac-disease/understanding-celiac-disease-2/dermatitis-herpetiformis/ https://www.gluten.org/resources/getting-started/dermatitus-herpetiformis/ Please read up on this. She can get the rash tested for the disease if it is DH.