No popular authors found.


Get Celiac.com's E-Newsletter

Categories

No categories found.







Ads by Google:


Questions? Join Our Forum:
~1 Million Posts
& Over 66,000 Members!



SHARE THIS PAGE:
Celiac.com Sponsors:

Celiac Disease and the Etiology of Lymphocytic Duodenosis: A Prospective Study


According to this study 16% of those with lymphocytic duodenosis have celiac disease.

Celiac.com 12/29/2010 - A team of researchers recently conducted a prospective study the etiology of lymphocytic duodenosis. Among their findings are that sixteen percent of patients with lymphocytic duodenosis have celiac disease.

The research team was made up of I. Aziz, K. E. Evans, A. D. Hopper, D. M. Smillie, and D. S. Sanders. They are affiliated with the Department of Gastroenterology at Royal Hallamshire Hospital in Sheffield, UK.

The study came in response to earlier retrospective studies that have suggested different connections with lymphocytic duodenosis, indicating that patients with this condition should not be diagnosed with celiac disease, solely by histology.

Lymphocytic duodenosis is marked by normal villous architecture and less than 25 intraepithelial lymphocytes (IELs) per 100 enterocytes.

For their study, the team thoroughly evaluated one hundred patients with lymphocytic duodenosis for celiac disease and other aspects associatedwith lymphocytic duodenosis by using initial celiac blood screens, and excluding the presence of infection.

Ads by Google:

Of thirty-four patients with unexplained lymphocytic duodenosis, twenty-nine underwent repeat duodenal biopsies following a gluten challenge. Biopsy results showed that 16% of patients with lymphocytic duodenosis had celiac disease.

Once celiac disease was accounted for, the factors most commonly association with lymphocytic duodenosis were as follows: drugs were a factor in twenty-one percent of lymphocytic duodenosis patients; infection was a factor in nineteen percent, immune dysregulation was a factor in four percent, inflammatory bowel disease and microscopic colitis in two percent each, sarcoidosis and IgA deficiency in one percent of cases, respectively.

Of thirty-four patients with no known associations, eighteen showed symptoms of irritable bowel syndrome (IBS). Of twenty-nine patients examined with repeat duodenal biopsies, the IEL count returned to normal in twenty-two patients.

The study results show that known associations can be found in sixty-six percent of cases of lymphocytic duodenosis.

Importantly, sixteen percent will have celiac disease. In cases of lymphocytic duodenosis with no apparent cause, there may be a connection with IBS. In such cases the IEL count returns to normal on repeat biopsy in seventy-six percent.

Source:

Celiac.com welcomes your comments below (registration is NOT required).












Related Articles



1 Response:

 
tmm
Rating: ratingfullratingfullratingfullratingemptyratingempty Unrated
said this on
06 Jan 2011 12:18:44 AM PST
Wish "gluten challenge" was linked to its specifics.
AFAIK there's little consensus on length of time, quantity of gluten, or even # of times per day to ingest it.

Also, it seems strange that the article doesn't say all 34 were strictly gluten free before the challenge.
Personally, even when a UK study explicitly says gluten free, my 1st thought is "how much has 'deglutened' wheat starch?"

I've met many on this forum who feel as glutened from 200ppm products as from obvious gluten.

For all we know, another 16% or more showed no change w/ gluten challenge because they were never all that gluten free to begin with.




Rate this article and leave a comment:
Rating: * Poor Excellent
Your Name *: Email (private) *:




In Celiac.com's Forum Now:


If it is a lactose issue it will probably still bother you, early on over 10 years ago with my lactose intolerance I tried the goats cheese, it was not as painful but it still caused issues. You mention nuts, tried nut butters? I tolerate nut butters and cheese made with nuts very well. Homemad...

Yes Vitamin K is a big thing in my diet, not for the calcium issue for for helping stop bleeding. Due to the UC I make sure I eat something like kale, spinach, butter leaf each meal ALWAYs, paranoid about sorta funny. But I hope a constant supply helps my blood clot faster and perhaps lessen the ...

Hi Jherm I think some people on this board take nsaids but I find increasingly they make my stomach sore. It's difficult as I think nsaids used as anti-inflammatories aren't they and that would be useful in your circumstances I imagine. I do have a friend who like me has had gastrit...

Ennis_Tx, I am just now seeing your blog post. Look into Vitamin K and Boron both are important for Calcium levels. Vitamin D gets all the press but bone density has shown to improve with Vitamin K levels. Here is a quick google search about born from the Livestrong site. ...

Yes I'd love that! How do I send you my email address so the whole world Doesn't have it. Not that it really matters no one knows me lol.