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Increased Reflux and Irritable Bowel Syndrome in Celiacs Yields Lower Quality of Life


Study on quality of life in celiacs with IBD and acid reflux.

Celiac.com 03/04/2011 - Celiac disease is similar to the inflammatory bowel diseases, ulcerative colitis and Crohn’s disease, in the obvious sense that all are chronic inflammatory disorders of the gastrointestinal tract.  But more than that, they all also present daily psychological and social challenges to patients’ lifestyles.  In a recent study reported in the European Journal of Gastroenterology and Hepatology, researchers in the United Kingdom examined the prevalence of GI symptoms in patients with these diseases and correlated the incidence of these symptoms with quality of life (QoL).  Not surprisingly, they found that increased severity of reflux and irritable bowel syndrome were associated with a diminished QoL.  Patients with celiac disease had worse symptoms and QoL than those with ulcerative colitis, but they were better off than people with Crohn’s disease.

This cross-sectional study was performed by sending patients surveys through the mail.  One thousand and thirty-one people were included; 225 patients with celiac, 228 with ulcerative colitis, 230 with Crohn’s disease, and 348 healthy age- and sex-matched controls.  As this was a postal survey, there is a potential inclusion bias – it is possible that those patients faring the worst would be most likely to send back the questionnaires.  Seventy one percent of the celiac patients reported adhering to a gluten-free diet, but this was not corroborated endoscopically.  One of the surveys assessed physical and mental QoL and another considered depression and anxiety.  Participants were also asked to report and rate GI symptoms they had experienced over the past month, including reflux, heartburn, regurgitation, belching, dysphagia (difficulty swallowing), and retrosternal pain.

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Barrat et al. found that the celiac patients had higher rates of belching and dysphagia than inflammatory bowel diseases sufferers in this study and also than reported previously.  They highlight that despite the high (71%) degree of adherence to the gluten-free diet, 22% of celiac patients still reported severe enough IBS symptoms to affect their QoL.  They infer from this finding a couple of noteworthy things.  First, that the gluten-free diet may not adequately control IBS symptoms in celiac patients.  But also, that doctors are perhaps not inquiring about reflux and IBS during consultations, or patients are under-reporting their prevalence.  The authors thus suggest that QoL might be improved for these patients if doctors were more diligent in assessing them for reflux and irritable bowel syndrome.

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2 Responses:

 
tmm
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said this on
04 Mar 2011 4:20:03 AM PST
Incredible that they'd call 71% GF a "high degree of adherence".
And then their solution isn't "tell them to BE GF!", it's "watch for treatable symptoms, probably resulting from the gluten".

I wish this article concluded w/ comments by Dr Gitig.

 
Hallie
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said this on
05 Mar 2011 11:19:12 PM PST
Anyone with dysphagia, reflux, and diarrhea (with or without alternating constipation) really should be checked for the antibodies associated with scleroderma: antinuclear antibodies done by IFE methodology, and more specifically Scl-70, anticentromere, U1-RNP, RNA polymerase III and PM/Scl.




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Great so they are safe! Good because I bought a bag and jab been suffering with a sore throat so this will definitely soothe it. Thanks!

Hi Louie, Welcome to the forum! It's true, you probably are doing the gluten-free diet wrong. The gluten-free diet is a huge change for many people, and it can take sometime to learn it and how to avoid all the places gluten can hide in foods. Really I consider the first 6 months a be...

No that's a really good point mate. I'll amend my post also. Thanks for pointing it out

Just needed to point this out while it seems the UK and perhaps even Canada they are. The US McDonalds has wheat in the fries. Second thought in the US you have to a take more careful with CC and chains, the kids go in and out of these like crazy and think gluten free is a kind of fad. I would ...

I hope I'll be fine too.