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DHA Therapy to Modulate Mucosal Inflammation in Celiac Patients


New research indicates DHA could help treat celiacs.

Celiac.com 04/13/2011 - When people with celiac disease consume gluten, their intraepithelial lymphocytes (IELs) wreak havoc in their guts by promoting inflammation and attacking the epithelial cells lining the intestines. This autoimmune activity is mediated by arachidonic acid (AA), a cytokine produced by the IELs. But there is data that the enterocytes "the very intestinal epithelial cells attacked by the IELs" can also produce and secrete AA in response to inflammation. Do they do so in celiac disease?

A recent study reported in Clinical Nutrition set out to determine just that. Using Caco-2 cells, a human intestinal epithelial cell line commonly used as an in vitro model of celiac disease, Vincentini et al. are the first to find that when these enterocytes were exposed to gliadin peptides, they did in fact generate and release arachidonic acid.

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Docosahexaenoic acid (DHA) is a long chain polyunsaturated fatty acid that counteracts many of the inflammatory effects precipitated by AA. When Caco-2 cells were treated with gliadin peptides and DHA, they produced much less AA (although they still made more than untreated cells). Treatment with DHA also reduced the production of other molecules involved in inflammation that were increased by exposure to gliadin, including cyclooxygenase (COX)-2, prostaglandin E2 (PGE2), and interleukin (IL)-8. PGE2 is particularly interesting, as it can increase the intestinal paracellular permeability that has been suggested to be the initial event in the pathogenesis of celiac disease.

The authors suggest that by blocking the release of AA, DHA might be a tenable therapeutic option for modulating mucosal inflammation in newly diagnosed celiac patients.

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3 Responses:

 
Kim heartsong
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said this on
19 Apr 2011 5:57:18 AM PDT
Thank you for this. I can not handle fish oil and switched to Krill oil. thank you for confirming my suspicions that krill oil is helpful for my intestines.

 
Beth Crow
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said this on
08 Aug 2011 12:41:59 PM PDT
So...maybe try the vegetarian form of DHA...it contains more DHA than it does EPA.

 
Margaret Pellegrini
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said this on
19 Mar 2012 6:47:18 PM PDT
This is good news and I hope it helps other celiacs like me. I can, at least for now, eat no grains, legumes, or refined sugar.




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I would not worry. Things might resolve on the gluten free diet as celiac disease does impact fertility in many ways. I hit perimenopause at 40. It lasted over a decade (the range of years varies from person to person) and I experienced every single perimenopause symptom (on and off) in the book. I was diagnosed with celiac disease after I went though menopause because of anemia that would not resolve. You could ask your GP/PCP to order a hormonal panel (include thyroid) if you see him/her sooner. This will let you know if you are starting perimenopause. My Mom breezed through menopause. Not me!!!!!

.." Gluten Free Watchdog we have been testing a wide variety of products with the Nima Sensor. It is very difficult to put the results of testing completed to date into proper context due to the lack of a published validation report on this device. One goal of our testing is to provide recommendations for consumer use of the Nima Sensor. This is proving to be impossible at this time. In the opinion of Gluten Free Watchdog the Nima Sensor was released into the marketplace prematurely. Given the current state of development of this sensor, Gluten Free Watchdog cannot support its use by the gluten-free community at this time...." https://www.glutenfreewatchdog.org/news/gluten-free-watchdogs-position-statement-on-consumer-use-of-the-nima-sensor-to-test-food-for-gluten/

https://www.glutenfreewatchdog.org/news/gluten-free-watchdogs-position-statement-on-consumer-use-of-the-nima-sensor-to-test-food-for-gluten/ "t Gluten Free Watchdog we have been testing a wide variety of products with the Nima Sensor. It is very difficult to put the results of testing completed to date into proper context due to the lack of a published validation report on this device. One goal of our testing is to provide recommendations for consumer use of the Nima Sensor. This is proving to be impossible at this time. In the opinion of Gluten Free Watchdog the Nima Sensor was released into the marketplace prematurely. Given the current state of development of this sensor, Gluten Free Watchdog cannot support its use by the gluten-free community at this time."

Yeah, I was pretty surprised. However, lots and lots of fantastic wine and gin. Even the house wine at a pub is going to be a nice French or Spanish something. Also drank a lot of port. And they take their gin super seriously there, some really good stuff. The closest I got to having a beer was trying some gin distilled from geuze (wild-fermented beer). Very nice. Make up for the lack of beer by eating all the fries.

This sounds familiar. Does the pain feel like its actually in your ribs, sore when you press on it? It could be costochondritis, which is inflammation of the cartilage between your ribs. It seems to be one of those weird things that tends to affect celiacs, could be a symptom of glutening or brought on by something else. I had a bad case of it a few months after going gluten free. Started as just a weird ache, and one morning it felt like I was being stabbed. Spent all day in emergency while they ruled out heart issues. Anti-inflamatories helped and it went away after a few days. Never came back that bad again. It could also just be heartburn-type symptoms triggered by gluten. I would see a doctor though, because you want to rule out whether its your heart or something. You're still early in your healing process, so not only are you probably not an expert at the gluten-free diet yet, but your body is readjusting to the new reality and doing all kinds of weird stuff. Hopefully this will resolve soon and not be a regular occurrence. It would only have a connection to your bowel issues in that it could be yet another fun affect of Celiac disease. Good luck and feel better soon!