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DHA Therapy to Modulate Mucosal Inflammation in Celiac Patients


New research indicates DHA could help treat celiacs.

Celiac.com 04/13/2011 - When people with celiac disease consume gluten, their intraepithelial lymphocytes (IELs) wreak havoc in their guts by promoting inflammation and attacking the epithelial cells lining the intestines. This autoimmune activity is mediated by arachidonic acid (AA), a cytokine produced by the IELs. But there is data that the enterocytes "the very intestinal epithelial cells attacked by the IELs" can also produce and secrete AA in response to inflammation. Do they do so in celiac disease?

A recent study reported in Clinical Nutrition set out to determine just that. Using Caco-2 cells, a human intestinal epithelial cell line commonly used as an in vitro model of celiac disease, Vincentini et al. are the first to find that when these enterocytes were exposed to gliadin peptides, they did in fact generate and release arachidonic acid.

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Docosahexaenoic acid (DHA) is a long chain polyunsaturated fatty acid that counteracts many of the inflammatory effects precipitated by AA. When Caco-2 cells were treated with gliadin peptides and DHA, they produced much less AA (although they still made more than untreated cells). Treatment with DHA also reduced the production of other molecules involved in inflammation that were increased by exposure to gliadin, including cyclooxygenase (COX)-2, prostaglandin E2 (PGE2), and interleukin (IL)-8. PGE2 is particularly interesting, as it can increase the intestinal paracellular permeability that has been suggested to be the initial event in the pathogenesis of celiac disease.

The authors suggest that by blocking the release of AA, DHA might be a tenable therapeutic option for modulating mucosal inflammation in newly diagnosed celiac patients.

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3 Responses:

 
Kim heartsong
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said this on
19 Apr 2011 5:57:18 AM PDT
Thank you for this. I can not handle fish oil and switched to Krill oil. thank you for confirming my suspicions that krill oil is helpful for my intestines.

 
Beth Crow
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said this on
08 Aug 2011 12:41:59 PM PDT
So...maybe try the vegetarian form of DHA...it contains more DHA than it does EPA.

 
Margaret Pellegrini
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said this on
19 Mar 2012 6:47:18 PM PDT
This is good news and I hope it helps other celiacs like me. I can, at least for now, eat no grains, legumes, or refined sugar.




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