No popular authors found.


Get Celiac.com's E-Newsletter

Categories

No categories found.







Ads by Google:


Questions? Join Our Forum:
~1 Million Posts
& Over 66,000 Members!



SHARE THIS PAGE:
Celiac.com Sponsors:

IL-15 Allows Inflammation in Celiac Guts by Suppressing the Immunosuppressive Effects of Treg Cells



Celiac.com 06/06/2011 - The interplay among the different immune cells mediating intestinal inflammation in celiac disease is complicated indeed. A subset of T regulatory (Treg) cells that express the Foxp3 protein are present in higher numbers in the intestines of patients with active celiac disease than in healthy controls. Treg cells act to suppress the immune system, providing tolerance to self-antigens. A recent report in the American Journal of Gastroenterology demonstrates that these cells proliferate upon the ingestion of gluten in order to suppress an overactive inflammatory response, but that their suppression is in turn suppressed by interleukin-15.

Ads by Google:

First they confirmed that there is in fact increased expression of Foxp3+ cells in the intestinal mucosa of untreated celiac patients; happily, they write that "no significant differences were noted in the number of Foxp3+ cells in biopsy samples of treated celiac disease in comparison with biopsy samples of non-celiac disease controls." Next, they used an in vitro gliadin challenge system - no celiac patients were harmed during the course of this study! - to see if the increase in this cell population was dependent on gliadin, and it was. T cells are so named because they are made in the thymus; this demonstration that they can originate in the small intestine lamina propria is interesting. Treg cells are generally immunosuppressive, and the Treg cells isolated from celiac guts demonstrated this immunosuppressive ability in vitro. So the researchers wondered: why is there still so much inflammation in untreated celiac disease patients? They found that the cytokine IL-15 could suppress the proliferation of Treg cells, and completely shut down their ability to produce interferon gamma (IFN- γ ). This is at least partially because Treg cells from celiac patients turn out to have a significantly higher surface density of receptors for IL-15 than Treg cells from healthy controls, rendering them more sensitive to IL-15's effects.

Zanzi et al bolstered their findings by achieving the same results using two independent experimental methods. It is not yet clear how IL-15 impairs the suppressive activity of Treg cells. But these scientists are actively working on it.

Source:

Celiac.com welcomes your comments below (registration is NOT required).












Related Articles



Comments




Rate this article and leave a comment:
Rating: * Poor Excellent
Your Name *: Email (private) *:




In Celiac.com's Forum Now:


It sounds like your hives resolved. I had a six month bout with them. Antihistamines really helped. My doctors are not sure if Mast Cell or autoimmune is the root cause.

My kid has Raynauds. It freaks her classmates out. She wears shoes and wool socks all year round and we live in a warm state. It is autoimmune. She manages it by layering, turning up the heat, use lots of blanket throws. I have Hashimoto?s and celiac disease. So, having multiple autoi...

Well, you do need to replace some things because they are too porous or damaged to remove gluten. Things like old wooden spoons, scratched non-stick pans, toaster, colander, sponges, etc. Honestly, the list is long, so try getting a few celiac books at the library or Amazon. Consider reading t...

When I woke up from my Endoscopy and was told I definitely had celiac disease the first thing I asked my doctor was do I need to get all new kitchen stuff? He assured me that I did not, and as long as my pots and pans and everything else was washed after being used to cook gluten I would have no ...

They have all given you good advice. Like Ennis_Tx said this is not medical advice. Just some observations. Ennis_Tx mentioned already a good B-complex. But people who have Perncious Anemia low B-12 have "Pens and Needles' feeling in their extremities. Mine was much more ...