No popular authors found.
Ads by Google:

Categories

No categories found.


Get Celiac.com's E-Newsletter




Ads by Google:



Follow / Share


  FOLLOW US:
Twitter Facebook Google Plus Pinterest RSS Podcast Email  Get Email Alerts

SHARE:

Popular Articles

No popular articles found.
Celiac.com Sponsors:

High Transaminase Levels Common in Celiac Disease


New study on high transaminase levels in celiac disease.

Celiac.com 07/13/2011 - Some people who follow a gluten-free diet due to celiac disease may develop unusually elevated levels of liver enzymes, according to researchers from Finland. The results are reported online in the American Journal of Gastroenterology.

Contrary to some earlier studies, the results show that only a small minority of these celiac disease patients showed elevated transaminase levels.

Dr. Markku Maki from University of Tampere points out that doctors don't routinely test transaminase levels in newly diagnosed celiac disease patients.

With this in mind, the research team examined the prevalence and gluten dependency of hypertransaminasemia in 313 untreated and 339 treated adult celiac disease patients and in 237 nonceliac control subjects.

They checked transaminase levels in 130 celiac disease patients at diagnosis and after one year on a gluten-free diet. They also conducted a before and after gluten challenge in 25 treated celiac patients who showed clinical remission.

Their cross-sectional study showed elevated aspartate transaminase (AST) levels in a similar proportion of untreated celiac patients (11%), treated celiac patients (8%), and healthy controls (9%). Earlier studies showed that up to half of celiac disease patients may have elevated serum liver enzyme levels at diagnosis.

The celiac patients showed significantly higher rates of hypertransaminasemia when their celiac symptoms were severe or moderate than when their symptoms were mild or nonexistent (23% vs 9%; P=0.03).

The team suggests that routine investigation of liver enzymes in celiac disease patients would likely provide the same yield as in the general population--"at least in populations with high clinical prevalence of celiac disease," they say.

Ads by Google:

They further suggest that clinicians reevaluate strategies for routine investigation of liver enzymes in celiac disease patients.

After one year, results of the gluten-free diet trial showed that serum AST levels dropped significantly, even to normal levels, in conjunction with the disappearance of clinical symptoms.

In the gluten-challenge study, gluten antibodies reappeared in the blood samples of nine of the 25 celiac patients who had previously been in clinical remission. 18 of the 25 developed gastrointestinal symptoms. AST and 11 patients showed elevated levels of alanine transaminase (ALT).

When the patients resumed their gluten-free diets, their symptoms resolved, serum endomysial antibodies became undetectable, and serum transaminase levels returned to normal levels.

Dr. Maki says that "gluten may induce liver disease in celiac disease patients. Even if the liver manifestation is infrequent and mostly mild."

This is a potentially important discovery, because as Dr. Maki points out, when people with celiac disease regularly consume wheat, rye, and barley gluten, "the environmental insult in celiac disease, seem to trigger an autoimmune loop in genetically susceptible persons where formed autoantibodies target the autoantigen, transglutaminase 2, also in the liver."

Dr. Maki adds that the biological implications of this can be studied further. In the meantime, he stops short of recommending routine screening with liver function tests when celiac patients are first diagnosed, saying that there is simply no evidence to support that practice.

However, he does say that if a case finding for celiac includes elevated liver enzymes, patients should be checked for normalization of liver values once on a gluten-free diet.

Source:

Celiac.com welcomes your comments below (registration is NOT required).





Spread The Word







Related Articles



2 Responses:

 
Brian White
Rating: ratingfullratingemptyratingemptyratingemptyratingempty Unrated
said this on
13 Jul 2011 3:51:59 PM PDT
I though the article said that there was no difference between celiac and normal, so I don't understand your title?

 
Jefferson Adams
Rating: ratingfullratingfullratingfullratingfullratingfull Unrated ( Author)
said this on
25 Aug 2011 1:12:16 PM PDT
Read the article. It's more about liver function as it relates to celiac disease.

Note: Dr. Maki says that "gluten may induce liver disease in celiac disease patients. Even if the liver manifestation is infrequent and mostly mild."

Note the the conclusion: "if a case finding for celiac includes elevated liver enzymes, patients should be checked for normalization of liver values once on a gluten-free diet."




Rate this article and leave a comment:
Rating: * Poor Excellent
Your Name *: Email (private) *:




In Celiac.com's Forum Now:

All Activity
Celiac.com Celiac Disease & Gluten-Free Diet Forum - All Activity

Hi! My daughter is 19 was diagnosed at age 16. It took about 12-18 month s for her to fully heal from the damage and feel "normal" again. Also because of the damage done she had reactions to dairy, so you may want to try no or minimum dairy until youre fully healed. Just a suggestion. Hope you start feeling well soon!

Hi yall! New to this blog, but really glad it exists because I have lots of questions. First off, I'm Allie! I'm 17 and newly diagnosed Celiac after about 3 years of searching for answers. I initially went gluten-free on the recommendation of a friend, I felt better in about a month and then my pediatric gastroenterologist had me do the gluten challenge, and my symptoms were the worst they have ever been, and ones I barely noticed before became very present. I did the biopsy and was diagnosed, it's been about 2 weeks and my symptoms are still pretty bad, although my diet has no known sources of gluten or cross contamination. Wondering if anyone has any input on healing post gluten challenge, any tips or how long it took for you would be quite helpful! Thanks

Might want to look into a keto diet, I have UC on top of celiacs and keto is working great Yeah I have major nerve and brain issues with gluten, gluten ataxia with nerve issues and brain issues. Seems to cause my body to attack my brain and nerve system. My brain stumbles fogs, and starts looping, the confusion causes me to become really irritable, I call it going Mr Hyde. Like my mind will start looping constantly on thoughts and not move driving me literally mad, or it used to. Now days it is primary the numbness anger but the gut issues and sometimes random motor loss limit me motionless to the floor now days for the duration of the major anger effects. Used to be a lot more mental then painful gut. I did a mental trauma post on it on while back where I came out about all my mental issues with gluten.

^^^^^^ good info, tips and tricks^^^^^^^^^ yes, crumbs will make you sick. also, breathing flour/pancake mix, etc that is in the air because eventually, you're going to swallow some.

Hello I was diagnosed Dec 15 of last year and went totally gluten-free the next day. I actually got worse before I got better - it's a steep learning curve - but now, 4 1/2 months later I'm finally seeing improvement. Hang in there.