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Does Celiac Disease Protect Against Aspects of Type 1 Diabetes Mellitus? 07/22/2011 - Many reports indicate a hypercoagulative state in diabetes mellitus as result of endothelial damage. Numerous researchers have reported a strong association between type 1 diabetes mellitus (DM1) and celiac disease.

Clinical data indicate that vascular dysfunction can result from a cascade of biochemical events triggered by a metabolic malfunction. The net result changes the cells that line the interior surface of the blood vessels; from a surface called a thrombo-resistant surface to one called a thrombo-genic surface.

A research team recently set out to determine whether celiac disease in a group of DM1 patients is connected with a different expression of certain hemostatic factors, and with a different manifestation and/or progression of microvascular complications of DM1, as compared to patients with diabetes alone.

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For the study, the team enrolled ninety-four adult patients with DM1, who they then screened for celiac disease. They found anti-endomysial antibodies (EMA) in 13 of 94 DM1 patients (13.8%). The team then confirmed celiac disease diagnosis by histology and organ culture.

The mean age and duration of DM1 of patients also affected by celiac disease were similar to those patients with diabetes alone, but the groups showed very different parameters for metabolic control and hemo-coagulation. In DM1 patients with celiac disease those parameters include:

  • Significantly lower concentrations of glycosylated hemoglobin (HbA1c) (P.05), cholesterol (P.001), triglycerides (P.001), factor VII antigen (FVII:ag) (P.005), factor VII coagulant activity (FVII:c) (P.05), and prothrombin degradation fragments (F1+2) (P.001).
  • Higher values of activated C protein (APC) (.001).
DM1 patients with celiac disease showed no retinal abnormalities and no signs of renal damage.

The results suggest a potential protective role of celiac disease in the pro-thrombotic state of DM1.

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6 Responses:

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said this on
25 Jul 2011 5:56:16 AM PST
Interesting, thanks. I sure would love to know of any studies that look at the case where a celiac diagnosis is made prior to a Type 1 diabetes diagnosis (typically it's the T1 first, then celiac, as I'm sure you know).


said this on
21 Mar 2013 3:07:22 PM PST
I have celiac disease and dermatitis herpetiformis. My brother also has celiac disease - he was diagnosed about 3 years ago and was just recently diagnosed with Type 1 diabetes. I am now what they are calling borderline diabetic.

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said this on
25 Jul 2011 11:51:06 AM PST
This is fascinating. My daughter has both celiac and type 1 diabetes. The combination makes social life difficult (as well as physical health). It is really nice to read something that suggests something positive about celiac other than the many dire possibilities and connections with other diseases!

Thank you for all the work you do! I refer to your safe and unsafe list all the time.

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said this on
30 Sep 2011 5:01:22 AM PST
Thank you for the good news. I am type 1 diabetic diagnosed 40 years prior to coeliac. I showed a mild retina alteration about 30 years ago. ever since then i have not developed any further diabetes complication to the amazement of my diabetes doctor.

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said this on
11 Jan 2012 9:33:24 PM PST
This is a really interesting article. I am both a type one diabetic and have celiac disease. I got type 1 when I was five years old and now am 21. I am hanging on by a thread with it because being on an insulin pump tends to be a real struggle for me because of skin irritation and the sites giving me issues but I cope with it. When I was a sophomore in high school I was tested for celiac disease because my endocrinologist had a strong feeling that I was carrying the symptoms for it. She sent me to a doctor she recommended and turned out I was borderline celiac and still am. I can't say I follow the celiac diet to a T because it is hard to handle and keep in line but I try my best and try to cut out gluten in my diet as often and much as possible. I face the fact that nothing is perfect and celiac is a tough thing to deal with. A combination of both these diseases really hit hard and already having diabetes since 11 years prior really scared me because many of the alternatives include rice and high starch and carbohydrate food products and being on an insulin pump, your goal is to eat healthy and try to eliminate those types of things as much as possible to control sugar as well as keep your insulin intake down. I am personally turned off by rice and the thoughts of eating it just scare me because I always feel awful afterwards. I choose to not eat it even though I am celiac dependent. All I can say to anyone who is in this type of situation is to take everything day by day, you can definitely take it on if you put your mind to it. It is hard but everything in life is and this is just another step you have to take to make it through your life and to live a healthy and happily as well. Good luck to all.

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said this on
05 Jul 2012 5:57:53 AM PST
Thank you for this article and also thanks to the comment by Holly. I was diagnosed with Type 1 at age 3 and am now 31. I was on in insulin pump from 2004 until this past January, when my pump broke and I decided to try injections for a time. I also have problems with irritation of the skin and wanted to see if using injections would work. I have now been on injections for 5 months and my HbA1C has run about the same as when on the pump. You might give the pump a rest for a few months and then try again. Sometimes I think that we need a break.

Also, I started having stomach issues last year and was finally diagnosed with gluten sensitivity, along with other sensitivities to rice, pork, chicken, beef, soy, corn, pumpkin and coconut. What am I supposed to eat, especially when this culture lives off of rice and chicken?

So, Holly, I understand your dilemmna. Because I live in Thailand, I can't test for celiac, but I could do a test by Enterolab that tested for food sensitivities. You might also check out MRT (Mediator Release Test). If rice irritates your stomach you might also be sensitive to that. I am. When I return to the states this year I will test for celiac disease and other food sensitivities.

Blessings and yes, I agree that if you put your mind to it, you can have a blessed life. It is challenging, no doubt.

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Those are indeed great ideas, thank you very much! Will look into the gluten free breading.

41 is very high. 300 is very extremely high.

Can I just ask what Is the difference between tt igg and tt Iga?

I have just had my blood tests for coeliac and one was normal I?m guessing that was iga and my other was 41 which I think was the ttg which I guessed was pretty high but have now seen people getting results of 300! So now I?m thinkong mine isn?t very high and maybe I don?t have coeliac? What were...

I have Julian Bakery Bars, Miracle Noodle MRE, I also have cans of freeze dried eggs. Gluten Free Emergency kits, Mountain House, Thrive, and Augason Farms (used to) have gluten free options of freeze dried foods. Make sure you check the box or look at the gluten-free versions of selections but t...