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Celiac Disease: Vitamin D and K Levels Influence Bone Mineral Density in Children and Teens


Celiac.com 11/07/2011 - Fat-soluble vitamin malabsorption, inflammation and/or under-nutrition put children with celiac disease at risk for decreased bone mineral density.

A research team recently set out to determine how vitamin D and K might influence bone mineral density and bone growth in children and adolescents with celiac disease. The study team included D. R. Mager, J. Qiao, and J. Turner.

The team's goal was to examine the interrelationships between vitamin K/D levels and lifestyle factors on bone mass density in children and adolescents with celiac disease at diagnosis and after 1 year on the gluten-free diet.

The team studied children and adolescents aged 3–17 years with biopsy proven celiac disease at diagnosis and after 1 year on the gluten-free diet.

To measure bone mineral density the researchers used dual-energy X-ray absorptiometry, factoring in relevant variables including anthropometrics, vitamin D/K status, diet, physical activity and sun exposure.

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The children saw their lowest BMD-z scores for whole-body and lumbar-spine (−1) at diagnosis (10–20%) and after 1 year (30–32%), independent of symptoms.

Older children (>10 years) showed substantially lower BMD-z scores for whole-body (−0.55±0.7 versus 0.72±1.5) and serum levels of 25(OH) vitamin D (90.3±24.8 versus 70.5±19.8 nmol/l) 
as compared with younger children (10 years) (P<0.001).

Overall, forty-three percent showed suboptimal vitamin D status (25(OH)-vitamin D <75 nmol/l) at diagnosis. Nearly half of these vitamin D deficiencies corrected after 1 year on the gluten-free diet.

Also, twenty-five percent of the children showed suboptimal vitamin K status at diagnosis. All vitamin K deficiencies resolved after 1 year.

Both children and adolescents with celiac disease face a substantial risk for suboptimal bone health at time of diagnosis and up to 1 year after adopting a gluten-free diet. This higher risk is likely due in part to suboptimal vitamin D/K levels.

Children and teens with celiac disease may benefit from treatment regimens that promote optimal vitamin K/D intake.

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1 Response:

 
Wilmer
Rating: ratingfullratingfullratingfullratingfullratingempty Unrated
said this on
17 Sep 2012 10:02:45 AM PDT
Excessive nutrition info on the internet! How to choose the right diet?




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Just watch out. I just went to the expo in Schaumburg, IL, and ended up getting glutened. I realized afterward that I ate all these samples thinking they were gluten free, and they weren't. One company was advertising some sugar, and had made some cake, but then I realized.... How do I know if this contains any other ingredients that might have gluten? Did they make it with a blender or utensils that had gluten contamination? Makes me realize the only safe things would be packaged giveaways with gluten free labeling. My fault for not thinking things through. It was just too exciting thinking i could try it all and enjoy without worry.

No fasting required for a celiac blood test unless they were checking your blood glucose levels during the same blood draw.

I wish! I got the flu this winter as well as a couple of colds. I do have 3 lids, the youngest in preschool, so there's always a lot of germs around. Lol

Hey again ? It's a start, but I so wish they'd done the whole panel. Some of us, myself included, test negative to the TTG-IgA. I was positive on the DGP only. I wonder if your insurance will only cover those 2? Regardless, get them done as soon as you can! Do you have a walk in lab where you live? If so, go tomorrow. Then you'll be a step closer to getting answers. Good luck and keep us posted!

I totally agree...this board is awesome! The people on here have been there for me through everything and it has helped so much! I don't think antihistamines would affect the test at all. I take an antihistamine daily as well for horrendous allergies.