22746 Bio-physical Characteristics of Gastrointestinal Mucosa of Celiac Patients: Comparison with Control Subjects and Effect of Gluten-Free Diet - Celiac.com
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Bio-physical Characteristics of Gastrointestinal Mucosa of Celiac Patients: Comparison with Control Subjects and Effect of Gluten-Free Diet

Celiac.com 11/28/2011 - Celiac disease often results in "leaky" intestinal mucosa. This development may involve changes in hydrophobicity of the mucus surface barrier along with changes of the epithelial barrier.

A team of researchers recently compared bio-physical aspects of gastrointestinal mucosa of celiac patients with control subjects, along with the effects of gluten free diet on each group.

Photo: CC -- spec-ta-clesThe research team included Stefania Bertolazzi, Francesco Lanzarotto, Barbara Zanini, Chiara Ricci, Vincenzo Villanacci, and Alberto Lanzini.

The team set out to compare duodenal hydrophobicity as an index of mucus barrier integrity in 38 patients studied before and 68 patients during gluten-free diet, and in 90 control subjects. They also checked for regional differences of hydrophobicity in the gastro-intestinal tract.

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The team gauged hydrophobicity by measuring the contact angle (CA) (Rame Hart 100/10 goniometer) created by a single drop of water applied to intestinal mucosal biopsies.

Once the team pooled the results and evaluated the control groups, patients with histologically normal duodenal biopsies showed significantly higher CA (620 + 90)  than patients with biopsies showing Marsh 1-2 (580 + 100; p<0.02) and Marsh 3 lesions (570+ 100; p<0.02).

Among the control group, the action sequence of hydrofobicity along the gastrointestinal tract follows the pattern: gastric antrum> corpus> rectum> duodenum> oesophagus> ileum.

From these results, the team concludes that people with celiac disease experience reduced hydrophobicity of duodenal mucous layer, and a reduced ability to repel luminal contents. This may may contribute to the increased intestinal permeability seen in celiac disease.

This change in hydrofobicity corresponds to the severity of the mucosal lesions in the patient, and is not completely reversed by gluten-free diet.

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9 Responses:

 
Allen G. Reiter
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said this on
28 Nov 2011 7:31:59 AM PDT
It would be helpful for this article to be written in layman's terms. I doubt that most readers will understand its point.

 
lAURA
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said this on
15 Jan 2012 8:34:34 AM PDT
I agree. What the heck is it telling us?

 
dot
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said this on
28 Nov 2011 9:13:56 PM PDT
I get it, but what do I do about it?

 
Laurie Massey
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said this on
05 Dec 2011 6:11:21 AM PDT
My sentiments exactly!!! What are we to do about permeability and malabsorption issues???

 
Jane
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said this on
05 Dec 2011 6:57:24 AM PDT
I agree. Layman's terms. Had to look up a number of words.....takes a great deal of time in this busy world.

 
admin
( Author)
said this on
06 Dec 2011 4:17:37 PM PDT
We do our best to update our glossary...note that you can click on many of the terms to get a definition.

 
Gloria Brown
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said this on
05 Dec 2011 10:47:31 AM PDT
For celiacs gluten can irreversibly damage the intestinal lining, so that its contents "leak" into the rest of the body, a set-up for eventual major disease. At the moment, eating fresh food only and keeping one's environment gluten-free, are one's best defense.

 
Robena
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said this on
05 Dec 2011 1:33:21 PM PDT
I totally agree with Dot. I get it because I live with it, but how do I get rid of it?

 
Suzanne
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said this on
05 Dec 2011 10:45:28 PM PDT
I understand that they are saying that we who are gluten-intolerant are not able to form a protective layer to keep the contents of our intestines inside (so some leaks out into the bloodstream). What do they mean, however, by that not being resolved by a gluten-free diet? Never? Do we always have a leaky gut? (I have heard that another gut gate-keeper that allows permeability, called Zonulin, also remains elevated in celiac disease--sounds like we're doomed!)




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Wish I could give you a hug. Unfortunately I know how that feels with Neurologists, Internists, Endocrinologists, Rheumatologists, GIs..... I got so tired of crying my drive home after refusing yet another script for Prozac. I do hope your GI can give you some answers even if it is just to rule out other possible issues. Keep on the gluten and we are here for you.

It is too bad that so often a full panel isn't done. Glad your appointment got moved up and hopefully you will get a clearer answer from the GI. Do keep eating gluten until the celiac testing is done. Once the testing is done do give the diet a good strict try. Hang in there.

That makes sense...I cried with relief when I got my diagnosis just because there was finally an answer. Please know that you are not weak or crazy. Keep pushing for testing. It could still be celiac, it could be Crohns. Push your Dr's to figure this out. Best wishes.

Thank you all very much. I actually cried when I got the answer. I wanted an explanation that I could "fix." Now I'm back to thinking I'm just weak and possibly crazy. I know I'm not crazy, but you know.

From what I have read online there is about a 1-3% chance of getting a false positive for celiac disease from a blood test. Was it a blood test that you got done? It may be worth your while to get a biopsy or more testing just to confirm it. I know being gluten free is a pain but it is better than getting cancer or other auto immune disorders.