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More Eosinophilic Esophagitis in Children and Adults With Celiac Disease

Celiac.com 01/04/2012 - A number of cases have led researchers to suspect a connection between eosinophilic esophagitis and celiac disease in children.

A research team sought to confirm this association in children, and determine whether it extends into adulthood. To do this, they reviewed data from a group of celiac disease patients to learn the number of patients who also had a diagnoses of eosinophilic esophagitis. 

Photo: CC - GreenFlames09The team included Jennifer S. Thompson, MD, Benjamin Lebwohl, MD, MS, Norelle Rizkalla Reilly, MD, Nicholas J. Talley, MD, PhD, Govind Bhagat, MD, and Peter HR. Green, MD.

For their study, they reviewed histopathology reports of esophageal biopsies to identify all cases of increased esophageal eosinophilia.

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The team defined cases of eosinophilic esophagitis as those where biopsies showed Z15 eosinophils per high power field and, which also included associated symptoms.

Using published US population-derived incidence data as a reference, they formulated age- and sex-adjusted standardized incidence ratios with corresponding 95% confidence intervals (CI).

In all, the team found 4 children and 10 adults with eosinophilic esophagitis, which makes eosinophilic esophagitis more common in people with celiac disease than in the general population.

Standardized incidence ratio was 35.6 (95% CI, 9.3-79.0) for children, and 13.1 (95% CI, 6.2-22.5) for adults. Overall, age-adjusted and sex-adjusted standardized incidence ratio was 16.0 (95% CI, 8.7-25.5).

This study found higher rates of eosinophilic esophagitis in patients with celiac disease than in the general population. The researchers advise doctors to consider the possibility of eosinophilic esophagitis for celiac disease patients who suffer ongoing esophageal problems.


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VSL #3 is safe and powerful probiotic. You get it at Costco in pharmacy or online. Metamucil is too hard on my system too. Psyllium husk is easier on the system and I tolerated it a little better. It did nothing for my husband because it was too gentle for him.

You might want to have your GI test for SIBO. Similar gut symptoms, common in celiacs, often agrivated by probiotics because you are adding more microbes to the overgrowth (FYI, the overgrowth is typically good bacteria is the wrong place). That's one of the next things they look for in a celiac still having symptoms.

thank you i will look for it. i was switching around ( culturelle, walgreens probiotic, walgreens probiotic with enzymes, just plain digestive enzymes) so, i know what you mean. at that point, i couldn't tell what was messing with my gut and what wasn't bothering me. ima try those, and *just* those and see how it goes. thanx again!

I found that I did not have enough iodine in my diet... so I take a Kelp pill... every day or so... I use Kosher salt and Pink Salt... so I need the iodine... I am shocked by what my ankles look like... I was always swollen... If you can eat shellfish... you should not have any issues with this...