No popular authors found.
Ads by Google:

Categories

No categories found.


Get Celiac.com's E-Newsletter





Ads by Google:


Follow / Share


  FOLLOW US:
Twitter Facebook Google Plus Pinterest RSS Podcast Email  Get Email Alerts
SHARE:

Popular Articles

No popular articles found.
Celiac.com Sponsors:

Influence of HLA-DQ2 and DQ8 on Severity in Celiac Disease

Celiac.com 03/14/2012 - A group of researchers recently studied the ways in which HLA-DQ2 and DQ8 might influence the severity of celiac disease. Specifically, the team wanted to study HLA-DQA1 and DQB1 profiles in adults with different forms of celiac disease, including adults with complicated and potential celiac disease, the most seriously affected, and those with the best preserved histologic end of the pathologic celiac spectrum.

Photo: CC - rdecomThe researchers included F. Biagi, P.I. Bianchi, C. Vattiato, A. Marchese, L. Trotta, C. Badulli, A. De Silvestri, M. Martinetti, and G.R. Corazza. They are affiliated with the Coeliac Centre/First Department of Internal Medicine, Fondazione IRCCS Policlinico San Matteo, University of Pavia, Italy. 

Patients with complicated celiac disease showed more HLA-DQB1*02 homozygosity than those with uncomplicated celiac disease.

Ads by Google:

The team conducted HLA-DQA1 and DQB1 molecular typing for 218 adults with celiac disease. Of these, 169 had uncomplicated celiac disease, 27 had complicated celiac disease, and 22 had potential celiac disease. They used 224 healthy stem cell donors as a control group.

The team analyzed HLA-DQA1 and DQB1 gene polymorphism using polymerase chain reaction sequence-specific primers and/or reverse polymerase chain reaction sequence-specific oligonucleotides. They found, as expected, that the frequency of HLA-DQB1*02 allele, DQB1*02 homozygosity, and DQB1*0302 gene were statistically different in the four groups.

However, multivariate analysis showed that patients with potential celiac disease have a higher frequency of both HLA-DQB1*0302 and HLA-DQB1*0603 alleles, along with a reduced frequency of DQB1*02 homozygosity, as compared with patients with uncomplicated and complicated CD.

The increased frequency of DQB1*0302 coupled with the reduced frequency of DQB1*02 homozygosity in potential celiac disease supports the idea that variations in clinical/pathologic expressions of celiac disease might reflect different immune system triggers. This observation could impact the way in which celiac disease is understood and studied in the future.

Source:

Celiac.com welcomes your comments below (registration is NOT required).












Related Articles



3 Responses:

 
angelie
Rating: ratingfullratingfullratingfullratingfullratingfull Unrated
said this on
19 Mar 2012 7:03:21 PM PDT
I learn more.

 
Daiane
Rating: ratingfullratingfullratingfullratingfullratingfull Unrated
said this on
19 Mar 2012 8:08:54 PM PDT
Excellent

 
Rhonda Jared
Rating: ratingfullratingfullratingfullratingfullratingfull Unrated
said this on
03 Apr 2012 12:42:07 PM PDT
2 copies of HLADQ8, 0302. Not sure what that means - allergy or celiac?




Rate this article and leave a comment:
Rating: * Poor Excellent
Your Name *: Email (private) *:




In Celiac.com's Forum Now:


You make a good point about being neurotic. I'm slowly getting better. I guess time will tell. But thank you for the insight. As far as roommates go, that's a good idea. I've definitely been thinking about that. But these guys are my best friends and the process of getting a new roomm...

Yes I have seen the allergist, dermatologist and tonight my general doctor and they all pretty much say I am crazy. The dermatologist did a scratch test and the results came back saying allergic contact dermatitis. So she has ordered a blood test for allergens gluten. Will this be the proper t...

My son is 5 and his symptoms are all behavioral and neurological. If he eats a few pretzels he will develop something called a stereotypy where his fingers become sort of stuck in distorted positions for days. If he eats gluten he also experiences auditory and visual hallucinations, insomnia, los...

Well.... it can be... the plastic lid on the lovely chicken salad you brought for lunch sticks, you pull too hard and it, and half your salad going flying all over the company computer?

@cyclinglady I heard that there were problems with Armour Thyroid when it came to gluten a few years ago. I thought it was no longer safe? @Megamaniac I had forgot to put that in my original post that I have a lot of issues with anxiety as well. I've never actually been officially diagnosed ...