No popular authors found.
Ads by Google:

Categories

No categories found.


Get Celiac.com's E-Newsletter





Ads by Google:


Follow / Share


  FOLLOW US:
Twitter Facebook Google Plus Pinterest RSS Podcast Email  Get Email Alerts
SHARE:

Popular Articles

No popular articles found.
Celiac.com Sponsors:

Contribution of Celiac Disease Autoantibodies to the Disease Process

Celiac.com 05/28/2012 - Two researchers recently conducted an assessment of the contribution of celiac disease autoantibodies to the disease process.

Photo: CC - Argonne National LaboratoryThe researchers were Katri Lindfors, of the Pediatric Research Center, University of Tampere & Tampere University Hospital and Katri Kaukinen, affiliated with both the School of Medicine, at the University of Tampere, and the Department of Gastroenterology & Alimentary Tract Surgery at Tampere University Hospital, both in Tampere, Finland.

The protein transglutaminase 2 is a multifunctional protein that plays a role in cellular adhesion.

Moreover, transglutaminase 2 has been identified as the auto-antigen in celiac disease, and in untreated celiac disease. In addition to being present in the serum, the transglutaminase 2-targeted autoantibodies are bound to their antigen in the basement membrane underlining the small-bowel mucosal epithelium.

Ads by Google:

Furthermore, studies have shown that disease-specific transglutaminase 2-targeted autoantibodies have a range of biological effects on different cell types.

By using Caco-2 intestinal epithelial cells, Lindfors and Kaukinen show that serum transglutaminase 2-targeted autoantibodies from untreated celiac patients inhibit the adhesion of these cells.

These results offer an important direction for future research to improve the basic understanding of celiac disease pathogenesis, and especially how disease-specific autoantibodies function as the disease progresses.

Source:

Celiac.com welcomes your comments below (registration is NOT required).












1 Response:

 
JERRY WELCH
Rating: ratingfullratingfullratingfullratingemptyratingempty Unrated
said this on
05 Jun 2012 4:26:33 PM PDT
Very interesting as I have celiac and I'm on a gluten free diet. My wife is well read but we are at a loss to find a doctor that is knolageable enough to really help us.




Rate this article and leave a comment:
Rating: * Poor Excellent
Your Name *: Email (private) *:




In Celiac.com's Forum Now:


I appreciate you.

This - I agree with all of this. I have also twigged that if oats are a problem then certified processed gluten free food is out. And I got really sick from drywall. It's such a relief to hear this as there was a time when I was feeling like an alien for thinking these things. Well I agree 99.9%....

Hi Celiac4762, The carbs I eat are sweet potato, parsnip and squash plus loads of fruit. With rice I'm ok if it's from a reputable source. If I ever get glutened by something then I steer clear of it for a month to give myself an extra break and then go back to it in smallish quantities. I h...

Thanks to both of you. Ok, so I was feeling not great and went grain free for 5 weeks. Then slowly started to introduce grains. All seemed ok, then I had an issue after 3 weeks, with blood in my stool. Celiac wasn't on my radar. In fact, rice and oats are what seem to bother me most. But the Dr a...

This is exactly what I'm wondering also.