No popular authors found.
Ads by Google:

Categories

No categories found.


Get Celiac.com's E-Newsletter





Ads by Google:


Follow / Share


  FOLLOW US:
Twitter Facebook Google Plus Pinterest RSS Podcast Email  Get Email Alerts
SHARE:

Popular Articles

No popular articles found.
Celiac.com Sponsors:

Gluten-dependent Antibodies in Horses with Inflammatory Small Bowel Disease

Celiac.com 05/11/2012 - Horses are susceptible to inflammatory small bowel disease, and the condition effects horses in much the same way as it effects humans.

Photo: CC-Moyan BrennAs with its human counterpart, equine inflammatory small bowel disease (ISBD) is an idiopathic pathologic condition that seems to be growing more and more common.

A research team recently conducted a study to examine the possibility that gluten may play a role in equine ISBD.

The researchers were J.H. van der Kolk, L.A. van Putten, C.J. Mulder, G.C. Grinwis, M. Reijm, C.M. Butler, B.M. von Blomberg of the Department of Equine Sciences, Medicine Section, Faculty of Veterinary Medicine at the University of Utrecht, in Utrecht, in the Netherlands.

For their study, the team assessed antibodies that are known to be important in the diagnosis of human celiac disease: IgA antibodies to human recombinant and guinea pig tissue-transglutaminase (TGA), native gliadin (AGA), deamidated-gliadin-peptides (DGPA), and primate and equine endomysium (EMA).

The team measured these antibodies using blood samples from three different groups of horses: Twelve ISBD affected horses on a gluten-rich diet, along with two control groups.

The first control group included 22 horses on a gluten-rich diet, and the second included 25 horses on a gluten-poor diet.

Ads by Google:

The researchers measured differences (p < 0.05) in the groups using the Wilcoxon test.

They found that both ISBD-affected horses and gluten-rich control group had significantly (p < 0.0004) higher hrTGA titers than gluten-poor control group.

However, ISBD horses did not show significantly higher levels of any of the CD related antibodies when compared to gluten-rich controls.

Still, They found significantly higher antibody levels (TGA, EMA and DGPA) in one of the ISBD horses.

They put that horse, 14-year-old stallion, on a gluten-free ration for 6 months. They then reassessed his antibodies and found a significant reduction of antibody levels, along with clinical recovery associated with improved duodenal histopathology.

The researchers write that this is the first such study assessing gluten-related antibodies in horses and that the results suggest a potential pathogenic role of gluten in at least some cases of equine ISBD.

These clinical results suggest that further study into the immunologic basis of possible gluten-sensitive enteropathy in horses might have important implications for the human manifestation of the disease.

Source:

Celiac.com welcomes your comments below (registration is NOT required).










Related Articles



2 Responses:

 
angelie
Rating: ratingfullratingfullratingfullratingfullratingfull Unrated
said this on
14 May 2012 5:56:22 PM PDT
Good reporting.

 
Brenta jane
Rating: ratingfullratingfullratingfullratingfullratingfull Unrated
said this on
15 May 2012 12:49:20 AM PDT
Fantastic article, thank you.




Rate this article and leave a comment:
Rating: * Poor Excellent
Your Name *: Email (private) *:




In Celiac.com's Forum Now:


Hello and welcome I don't have celiac. I do have several symptoms in common with you and I do have a problem with gluten, so NCGS for want of a better term. A celiac response to gluten involves the immune system so there certainly can be a delay between ingestion and the body producing...

This is why many of us stick to our own "Trusted Brands" of things we know are safe, and only buy stuff with the offical certification for gluten free. NOTE also in the US they do not HAVE to tell you their facility also processes wheat on the label, just if the actual product contains it in the ...

I make my own mini loafs of a simple almond,coconut,apple sauce blend for dense, bland bread gluten free, and have my pastor bless them. I then keep them in the freezer and bring a piece with me for communion.

I don't have milk in liquid form any more, so I switched to coconut flavoured milk (rice based) for cereal, really like it. Then I take coffee black which I've also adjusted to. For an occasional treat I'll have a soy latte, tastes a bit nutty but I'm used to it now and it's as much about the vis...

I and many others here have been there and sympathise! Keep on keepin' on, it won't be long now before you can start feeling better. In the meantime, if there's a cheesecake, pastry etc that you want to say goodbye to, now's the time...