No popular authors found.
Ads by Google:

Categories

No categories found.


Get Celiac.com's E-Newsletter





Ads by Google:


Follow / Share


  FOLLOW US:
Twitter Facebook Google Plus Pinterest RSS Podcast Email  Get Email Alerts
SHARE:

Popular Articles

No popular articles found.
Celiac.com Sponsors:

Higher Rates of Lymphoproliferative Disorders in Patients with Celiac Disease

Celiac.com 07/30/2012 - A number of studies have found higher rates of lymphoma in people with celiac disease. However, few studies make any distinction between lymphoproliferative disorders (LPDs).

Photo: CC--greencolanderA team of researchers recently investigated rates of various lymphoproliferative disorders in patients with celiac disease.

The research team included L.A. Leslie, B. Lebwohl, A.I. Neugut, J. Gregory Mears, G. Bhagat, and P.H. Green. They are affiliated with the Department of Medicine at Columbia University Medical Center in New York, NY.

The team wanted to assess rates of LPD subtypes in celiac disease patients, describe patterns of celiac disease presentation in patients who develop LPD, and compare survival in patients with various LPD subtypes.

To do so, they carried out a retrospective cohort study of adults with biopsy-proven celiac disease seen at a US referral center from 1981 to 2010. They also identified patients with comorbid LPD, and calculated standardized incidence ratios (SIR) for each LPD subtype.

Ads by Google:

They began with a study group of 1,285 patients with celiac disease. The group contained 40 patients with LPD [SIR = 6.48, 95% confidence interval (CI) = 4.62-8.64] including 33 with non-Hodgkin lymphoma (NHL, SIR = 6.91, 95% CI = 4.26-8.28).

Rates of NHL subtypes including enteropathy-associated T-cell (EATL, n = 12), non-EATL T-cell (SIR = 22.43, 95% CI = 7.08-46.41), diffuse large B-cell (SIR = 5.37, 95% CI = 1.93-10.52), mantle cell (SIR = 32.21, 95% CI = 6.07-78.97), and marginal zone (SIR = 37.17, 11.73-76.89), lymphoma were substantially higher
among patients diagnosed with celiac before LPD (n = 24, NHL SIR = 4.47, 95% CI = 2.86-6.44).

Patients who developed LPD were usually older at time of celiac diagnosis (57.9 ± 15.5 versus 42.5 ± 17.4 years, P < 0.0001) and more likely to present with diarrhea (60.0% versus 39.8% P = 0.016), abdominal pain (17.5% versus 5.5% P = 0.0046), and/or weight loss (12.5% versus 4.0%, P = 0.028).

EATL patients had a shorter average survival than non-EATL NHL patients (3.2 versus 15.0 years, P = 0.016).

Overall, rates of LPD are higher in celiac disease patients, and those diagnosed at an older age, who present with symptoms of malabsorption, are more likely to be diagnosed with LPD.

Source:

Celiac.com welcomes your comments below (registration is NOT required).












Related Articles



1 Response:

 
jane
Rating: ratingfullratingfullratingfullratingfullratingfull Unrated
said this on
07 Dec 2012 3:47:49 PM PDT
Wow, turns out I have this! Thanks you for posting this!




Rate this article and leave a comment:
Rating: * Poor Excellent
Your Name *: Email (private) *:




In Celiac.com's Forum Now:


You make a good point about being neurotic. I'm slowly getting better. I guess time will tell. But thank you for the insight. As far as roommates go, that's a good idea. I've definitely been thinking about that. But these guys are my best friends and the process of getting a new roomm...

Yes I have seen the allergist, dermatologist and tonight my general doctor and they all pretty much say I am crazy. The dermatologist did a scratch test and the results came back saying allergic contact dermatitis. So she has ordered a blood test for allergens gluten. Will this be the proper t...

My son is 5 and his symptoms are all behavioral and neurological. If he eats a few pretzels he will develop something called a stereotypy where his fingers become sort of stuck in distorted positions for days. If he eats gluten he also experiences auditory and visual hallucinations, insomnia, los...

Well.... it can be... the plastic lid on the lovely chicken salad you brought for lunch sticks, you pull too hard and it, and half your salad going flying all over the company computer?

@cyclinglady I heard that there were problems with Armour Thyroid when it came to gluten a few years ago. I thought it was no longer safe? @Megamaniac I had forgot to put that in my original post that I have a lot of issues with anxiety as well. I've never actually been officially diagnosed ...