No popular authors found.
Ads by Google:

Categories

No categories found.


Get Celiac.com's E-Newsletter




Ads by Google:


Questions? Join Our Forum:
~1 Million Posts
& Over 66,000 Members!



SHARE THIS PAGE:
Celiac.com Sponsors:

Testing IgG and IgA Antibodies Against Gliadin Not Helpful for Diagnosing Celiac Disease in Children Under 2 Years Old

Celiac.com 08/16/2012 - Tests for blood antibodies against native gliadin (anti-nGli) are still often assumed to perform better in the diagnosis of celiac disease in young children than tests for antibodies to deamidated gliadin (anti-dGli), tissue transglutaminase (anti-tTG), and endomysium (EmA).

Photo: CC--Håkan Dahlström.A team of researchers recently set out to determine whether testing IgG and IgA antibodies Against native gliadin was best for diagnosing celiac disease in children under 2-years old. Specifically they wanted to compare the performance of assays for anti-nGli, anti-dGli, anti-tTG, and EmA in this age group.

The research team included T. Richter, X. Bossuyt, P. Vermeersch, H.H. Uhlig, M. Stern, A. Hauer, K.P. Zimmer, L. Mearin, J.H. Roo, C. Dähnrich, and T. Mothes.

They are affiliated with the University Children's Hospital, the Children's Hospital of the Clinical Centre, "Sankt Georg," and the Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics at University Hospital in Leipzig, Germany; with the Department Laboratory Medicine of University Hospital in Leuven, Belgium, the University Children's Hospital in Tübingen, Germany, the University Children's Hospital in Graz, Austria, the University Children's Hospital in Giessen, Germany, the Department of Paediatrics at Leiden University Medical Centre in Leiden, The Netherlands, and with EUROIMMUN Medizinische Labordiagnostika GmbH in Lübeck, Germany.

For their study, they conducted a retrospective analysis of 184 children. The study group included 42 children with celiac disease under normal diet, and a control group of 142 children up to 2 years of age.

Ads by Google:

The team measured immunoglobulin (Ig) A- and IgG-anti-dGli, IgA- and IgG-anti-nGli, IgA- and IgG-anti-tTG, and IgA-EmA in blood samples. They calculated areas under receiver operating characteristics curves, sensitivities, specificities, positive and negative predictive values, positive and negative likelihood ratios, as well as diagnostic odds ratios.

When all the data was complete, they found that only tests for IgG-anti-dGli, IgA-anti-tTG, and IgA-EmA had high specificity (≥0.96) connected with high sensitivity (≥0.86), with high positive predictive values (≥0.52 and ≥0.69 at pretest probabilities of 0.05 and 0.1, respectively) and negative predictive values (≥0.99 and ≥0.98 at pretest probabilities of 0.05 and 0.1, respectively).

These tests also showed high positive likelihood ratio (≥24) at low negative likelihood ratio (≤0.15) and high diagnostic odds ratios (≥136).

From their data, the team concluded that using anti-nGli tests to diagnose celiac disease in young children was not helpful. They maintain that IgA-anti-tTG, IgA-EmA, and IgG-anti-dGli provided much more reliable results than anti-nGli in diagnosing celiac disease in young children.

Source:

Celiac.com welcomes your comments below (registration is NOT required).












Related Articles



1 Response:

 
Woodrow
Rating: ratingfullratingfullratingfullratingfullratingfull Unrated
said this on
25 Aug 2012 5:38:05 AM PDT
I love reading a post that will make men and women think.

Also, many thanks for permitting me to comment!




Rate this article and leave a comment:
Rating: * Poor Excellent
Your Name *: Email (private) *:




In Celiac.com's Forum Now:


Gluten free 01, I totally agree that gluten free light is not good. I sometimes have to eat every hour. This seems to be related to low cortisol and low female hormones. Maybe also other deficiencies. I don?t think going gluten free is the only solution to this problem. I am sure with the he...

I don't have a lot of time this morning but I did locate organizations section on gluten free label regs in Canada. There may be more info on this in that section that may be helpful in knowing why they are making that change. http://www.inspection.gc.ca/food/labelling/food-labelling-for-ind...

Funny you should mention this, I got a offer for some free ones from that company and just turned it down. The only gluten free products from the company are a 2 lines of dedicated nut type bars. The majority of their bars actually contain either barley (gluten grain) like the biscuits etc. Or wh...

There has been a recent recall of veggies because of listeria risk. Here is the FDA list of recalled items in the US and Canada https://www.fda.gov/Safety/Recalls/ucm581389.htm

I asked for their two products yesterday,onion and garlic.Onion powder's package doesnt have starch or wheat on ingredient list but garlic powder has corn starch . I dont have any intolerance to corn by the way. They told me they add starch to two of their products so they are not gluten fre...