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Celiac Disease in Type 1 Diabetes Mellitus

Celiac.com 08/20/2012 - People with Type 1 Diabetes (T1D) suffer from celiac disease at rates ranging from 4.4 to 11.1%, compared with rates of 0.5% for the general population.

Photo: CC--DeathByBokehThe reason for this connection is due at least in part to the fact that the HLA genotypes DR3-DQ2 and DR4-DQ8 are strongly associated with T1D, while DR3-DQ2 is associated with celiac disease.

To get a better sense of the issue, a research team recently assessed celiac disease in type 1 diabetes mellitus.

The research team included Maria Erminia Camarca, Enza Mozzillo, Rosa Nugnes, Eugenio Zito, Mariateresa Falco, Valentina Fattorusso, Sara Mobilia, Pietro Buono, Giuliana Valerio, Riccardo Troncone, and Adriana Franzese.

The are variously affiliated with the Department of Paediatrics, "Federico II" University, the School of Movement Sciences (DiSIST) at Parthenope University, and the Department of Cellular and Molecular Pathology "L. Califano", "Federico II" University, all in Naples, Italy.

People with T1D rarely show classical severe symptoms of celiac disease. Usually, they have few or mild symptoms of celiac disease, or show no symptoms at all (silent CD).

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In fact for T1D patients, diagnosis of celiac disease is usually done by blood screening.

The effects of gluten-free diet (GFD) on the growth and T1D metabolic control in CD/T1D patient are controversial.

There is some debate about whether gluten-free foods have a higher glycemic index compared with to gluten-containing foods; and also about whether gluten-free foods might be be lower in fiber and higher in fat.

Adherence to a gluten-free diet by children with CD-T1D has generally been reported at below 50%, compared with about 73% for those with celiac disease alone. Failure to follow a gluten-free diet is even more common among asymptomatic patients.

The more severe problems of gluten-free diet adherence usually occur during adolescence when non-compliant subjects report the lowest quality of life.

The researchers suggest providing psychological and educational support for these patients.

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Last December, I was horribly sick. Suddenly, questioning gluten; I didn't eat any. The change was beyond enormous, and I could not ever bring myself to voluntarily eat it, again. It was as if I was finally, not being electrocuted! A nasty, blistering rash went away, at the same time. Now, I am ...

Same here. Our doctor told us that my daughter does not have celiac right after the endoscopy. We were overjoyed. 2 weeks later, they called and gave us the test results, and that she does have celiac. I would wait at least until the actual results before worry about next steps.

Peanut butter is always my breakfast when I want to stay full for a while. When I am in a rush, I just eat a spoon of peanut butter and a glass of milk with some fruit. When I have a bit more time, I make toast with peanut butter. Cereal doesn't keep me full in general. I know you said you ...

My GI said the same thing, but he warned me that we would have to wait for the pathologist's report. Guess what? The report showed moderate to severe patches of intestinal damage. So, hang in there and just wait for those results.

What sort of side effects did you have? I feel like I still have acid every morning, upset stomach, bloating, burping, and poor tolerance to most food.