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What is the Effect of Celiac Disease on Growth and Glycemic Control in Patients with Type 1 Diabetes?

Celiac.com 09/19/2012 - Researchers have documented rising rates of celiac disease in patients with type 1 diabetes (T1D). A research team recently tried to assess the effect of celiac disease on growth and glycemic control in patients with T1D, and to determine the effects of a gluten-free diet on these parameters.

Photo: CC--Jill A. BrownThe research team included I. Taler, M. Phillip, Y. Lebenthal, L. de Vries, R. Shamir, and S. Shalitin. They are affiliated with the Department of Pediatrics B, Schneider Children's Medical Center of Israel in Petach Tikva, Israel.

To do so, they conducted a longitudinal retrospective case-control study, in which they reviewed the medical data on 68 patients with T1D and duodenal-biopsy-confirmed celiac disease. They looked at weight, height, hemoglobin A1c (HbA1c), frequency of diabetic ketoacidosis (DKA), and severe hypoglycemic events before and after diagnosis and treatment of celiac disease.

They then compared their findings with 131 patients with T1D alone, who were all matched for age, gender, and duration of diabetes.

In all, 5.5% patients with T1D who attended the center during the study period were diagnosed with celiac disease, while 26% of the patients with celiac disease were symptomatic.

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The data showed no significant differences in glycemic control or frequency of severe hypoglycemia or DKA events between the study group and control subjects.

Body mass index-standard deviation score (SDS), height-SDS, and HbA1c values were insignificantly higher in the control group than in the study group, and similar in celiac disease patients with good or fair/poor adherence to a gluten-free diet during follow-up.

Patients with T1D and celiac disease and following a gluten-free diet have growth and metabolic control similar to those with T1D with no celiac disease.

To determine whether a gluten-free diet is appropriate for asymptomatic celiac patients or only symptomatic patients must be assessed against possible short- and long-term consequences of no intervention, and the decision should be based on more evidence from larger randomized studies.

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Thanks for letting me know. My back hurts all the time

I had a pillcam done two and a half months after I went gluten-free and it only showed gastropathy. three and a half months before the pillcam and endoscopy showed damage consistent with celiac. That damage was after a 10 or 11 week gluten challenge. prior to that I was gluten-free for a ...

It works much better for me but everyone is different. I have a physical job and sometimes get lower back pain. A hot shower and an Aleve will usually relieve it. It's worth your giving it a try.

Is Aleve better than ibuprofen? My back pain doesn't budge with 800 mg Motrin.

When I was diagnosed, I had only anemia. That is it. Later I found that I had osteoporosis as a result of untreated celiac disease. There are over 200 symptoms attributed to celiac disease. You may have many or NONE at all (called silent). After going gluten free within months my anemi...