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Women With Celiac Disease At Lower Risk for Hormone-Related Cancers

Celiac.com 09/24/2012 - With all the problems that go along with celiac disease, it can be hard to see any benefits to having the disease. However, it would seem that such benefits do exist: a recent study in Sweden shows that women suffering from celiac disease are actually at a decreased risk of developing breast, endometrial and ovarian cancer.

Photo: CC--Paul FalardeauData was collected from 28 Swedish pathology departments, identifying 17,852 biopsy-diagnosed women diagnosed with celiac disease between the years of 1969 and 2007. Women in the celiac group were age-matched and compared with a control group of 88,400 women.

Risk of breast, endometrial and ovarian cancer were all estimated using the Cox regression model in both groups. Results showed an inverse relationship between celiac disease and all three forms of cancer. With breast cancer rates, women with celiac disease had a hazard ratio of 0.89 (meaning for every 100 women in the control group, only 89 in the celiac disease group developed breast cancer). Women with celiac disease also had a hazard ratio of 0.89 for ovarian cancer. For endometrial cancer, the decreased risk was even more pronounced with a hazard ratio of 0.6. All calculations carried a confidence interval of 95%.

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These numbers became even more pronounced after omitting the first year of followup after diagnosis (presumably the gluten-free diet 'adjustment period'). Breast cancer's hazard ratio fell to 0.82, ovarian cancer's hazard ratio fell to .72 and endometrial cancer's hazard ratio fell to 0.58. 

The study suggests that this negative correlation could be a result of shared risk factors or early menopause associated with celiac disease. Looking at the numbers though, particularly the 'adjustment period' drop off, one has to wonder if the gluten-free diet has some part to play in this as well.

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5 Responses:

 
Donna
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said this on
24 Sep 2012 4:39:41 AM PDT
Strangely we have only had one case of breast cancer or any other type of cancer in many generations of many women. I have wondered about this lately. My mother has 6 sisters and early or sudden menopause is common here. This may explain it.

 
Paul Farley
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said this on
24 Sep 2012 7:53:53 AM PDT
It's really neat that the gluten-free diet possibly has a beneficial effect on cancer rates. Great news! Thanks for the article.

 
GlutenFreeDee
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said this on
24 Sep 2012 6:35:58 PM PDT
I love this positive info and wondered about the early menopause. I went through a quick change at 42. Done by 43.

 
Lissa
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said this on
03 Oct 2012 4:40:29 PM PDT
This is wonderful news!

 
Guadalupe
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said this on
30 Sep 2013 6:08:49 AM PDT
Isn't 89 out of 100 a LOT... ? Not sure I understand. Can you explain those ratios again?




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