No popular authors found.
Ads by Google:

Categories

No categories found.


Get Celiac.com's E-Newsletter





Ads by Google:


Follow / Share


  FOLLOW US:
Twitter Facebook Google Plus Pinterest RSS Podcast Email  Get Email Alerts
SHARE:

Popular Articles

No popular articles found.
Celiac.com Sponsors:

Refractory Celiac Disease: Unlocking the Origin of Aberrant Lymphocytes

Celiac.com 10/25/2012 - Abnormal intraepithelial lymphocytes (IELs) are the main feature of refractory celiac disease type II (RCDII). However, researchers still don't know exactly how these abnormal IELs originate.

Photo: CC--W. D. VanlueA pair of researchers recently commented on efforts to learn how these abnormal IELs might come about.

The pair were Victor F. Zevallos, and Detlef Schuppan, of the center for Molecular and Translational Medicine, Department of Medicine I at the University Medical Center of Johannes Gutenberg University Mainz, in Mainz, Germany.

Their commentary focuses on efforts by a separate research team, Schmitz, et al., which had already used a broad spectrum of cell specific markers, RNA array and immunological techniques, to explore abnormal IEL cell lines from four RCDII patients, and compare them with IELs from the fetal intestine, the intestine of children and adults and the thymus.

IELs are highly varied lymphocytes cells with innate and adaptive features that live in the small and large intestine. IELs play an important role in maintaining gut tolerance to common food antigens versus defense against pathogens.

Ads by Google:

A number of nutritional factors influence the development and spread of IELs, especially vitamins and their active metabolites, such as retinoic acid, and phytochemicals such as ligands of the aryl hydrocarbon receptor from cruciferous vegetables.

However, when IELs activate and expand uncontrollably in response to chronic inflammatory conditions in the gut, they trigger mucosal damage, which can lead to celiac disease, and in some cases, to malignant cancers.

Up to 5% of people with celiac disease, especially those who are over fifty years old when diagnosed, continue to suffer from clinical symptoms and villous atrophy even when following a gluten-free diet.

After excluding ongoing gluten consumption and other potential underlying diseases, all four patients studied by Schmitz could be diagnosed with RCD, which is classically classified as type I or type II, based on the histological co-expression of CD3 and CD8 in RCDI, or absence of such co-expression in RCDII.

Read the entire report in Gut.

Source:

Celiac.com welcomes your comments below (registration is NOT required).










2 Responses:

 
Barb
Rating: ratingfullratingfullratingfullratingfullratingfull Unrated
said this on
29 Oct 2012 5:38:57 PM PDT
They may be eating other grains that have a type of gluten in ithem. I can't eat corn and such things myself.

 
Greg Marlow
Rating: ratingfullratingfullratingfullratingfullratingempty Unrated
said this on
30 Oct 2012 7:41:48 AM PDT
Abnormal IELs appeared on my lips about one year before clinical symptoms of celiac disease. The dermatologist called them Fordice spots. She had no idea that they might be related to celiac disease.




Rate this article and leave a comment:
Rating: * Poor Excellent
Your Name *: Email (private) *:




In Celiac.com's Forum Now:

All Activity
Celiac.com Celiac Disease & Gluten-Free Diet Forum - All Activity

VSL #3 is safe and powerful probiotic. You get it at Costco in pharmacy or online. Metamucil is too hard on my system too. Psyllium husk is easier on the system and I tolerated it a little better. It did nothing for my husband because it was too gentle for him.

You might want to have your GI test for SIBO. Similar gut symptoms, common in celiacs, often agrivated by probiotics because you are adding more microbes to the overgrowth (FYI, the overgrowth is typically good bacteria is the wrong place). That's one of the next things they look for in a celiac still having symptoms.

thank you i will look for it. i was switching around ( culturelle, walgreens probiotic, walgreens probiotic with enzymes, just plain digestive enzymes) so, i know what you mean. at that point, i couldn't tell what was messing with my gut and what wasn't bothering me. ima try those, and *just* those and see how it goes. thanx again!

I found that I did not have enough iodine in my diet... so I take a Kelp pill... every day or so... I use Kosher salt and Pink Salt... so I need the iodine... I am shocked by what my ankles look like... I was always swollen... If you can eat shellfish... you should not have any issues with this...