No popular authors found.
Ads by Google:

Categories

No categories found.


Get Celiac.com's E-Newsletter





Ads by Google:


Follow / Share


  FOLLOW US:
Twitter Facebook Google Plus Pinterest RSS Podcast Email  Get Email Alerts
SHARE:

Popular Articles

No popular articles found.
Celiac.com Sponsors:

Capsule Endoscopy Useful in Diagnosing Refractory Celiac Disease

Celiac.com 01/02/2013 - Doctors use capsule endoscopy to assess the small bowel in a number of intestinal diseases, including celiac disease. The main advantage of capsule endoscopy is that it allows for complete visualization of the intestinal mucosal surface.

Photo: CC--tjmwatsonA team of researchers recently set out to investigate whether capsule endoscopy can predict the severity of celiac disease, and detect celiac disease complications.

The research team included M. Barret, G. Malamut, G. Rahmi, E. Samaha, J. Edery, V. Verkarre, E. Macintyre, E. Lenain, G. Chatellier, N. Cerf-Bensussan, and C. Cellier. They are affiliated with the Assistance Publique-Hôpitaux de Paris, Hôpital Européen Georges-Pompidou, Service d'Hépato-gastro-entérologie, and the Université Paris Descartes, Sorbonne Paris Cité, Faculté de médecine, both in Paris, France.

For their study, the team reviewed medical files for nine patients with symptomatic celiac disease, eleven patients with refractory celiac disease type I (RCDI), 18 patients with refractory celiac disease type II (RCDII), and 45 patients without celiac disease who received both capsule endoscopy and upper endoscopy or enteroscopy.

To properly diagnose the type of celiac disease in the patients, the researchers used a centralized histological review, flow cytometry analysis of intraepithelial lymphocytes, and the analysis of T-cell receptor rearrangement by multiplex polymerase chain reaction.

A total of 47 capsule endoscopies were administered for the 38 celiac patients: ten for the patients with symptomatic celiac disease; eleven for patients with RCDI; and 26 for RCDII patients. Another 47 capsule endoscopies were administered for the 45 non-celiac patients were retrospectively reviewed.

Ads by Google:

They found that patients with celiac disease had more villous atrophy, and more numerous, or distally located ulcers than the control subjects.

They also found that, in celiac disease patients, capsule endoscopy was of acceptable quality in 96% of cases and was complete in 62% of cases.

Moreover, the concordance of capsule endoscopy with histology for villous atrophy was better than that of optic endoscopy (κ coefficient =0.45 vs. 0.24, P<0.001).

Extensive mucosal damage on capsule endocscopy was associated with low serum albumin (P=0.003) and the RCDII form (P=0.02). The also detected three cases of overt lymphoma by capsule endoscopy during the follow-up.

Overall, the results show that capsule endoscopy provides a sufficient match with histology and nutritional status in patients with symptomatic or refractory celiac disease. Lastly, capsule endoscopy may predict the type of RCD and enable the early detection of overt lymphoma.

Source:

Celiac.com welcomes your comments below (registration is NOT required).












Related Articles



2 Responses:

 
Dieter Soehnel
Rating: ratingfullratingfullratingfullratingfullratingfull Unrated
said this on
03 Jan 2013 7:56:03 AM PDT
My serum albumin was within range (3.6-4.8 g/dl) throughtout 2012 and earlier. If my GI doc tells me I need a capsule endoscopy, I have some news for him. Thanks.

 
steven baker
Rating: ratingfullratingfullratingfullratingfullratingfull Unrated
said this on
04 Jan 2013 12:49:24 PM PDT
My wife was recently diagnosed with Celiac disease after years of feeling unwell. In the end she had a gastroscopy which confirmed her illness (quite severe I might add). The capsule endoscopy would have been ideal if she had known about it earlier. Thank you for the article.




Rate this article and leave a comment:
Rating: * Poor Excellent
Your Name *: Email (private) *:




In Celiac.com's Forum Now:


No anti-sm(lupus)? Yes, anti dsDNA is for SLE(lupus). No ENA panel,anti-RNP, anti-SS-A, anti-SS-B, anti histone, scl-70, etc? I'd ask for a referral, if you feel that there is something going on. I think that would be a logical step because of the positive ANA and lack of investigation. 1:640 is ...

My MCH is always high too. Have some other oddities but doc always say labs are great as well. I dont think they ever really bother with the MCH. I'm also in testing and showed negative on the same ones you did. My IGA is fine though. As far as the other tests, maybe your girls GI can order or yo...

Hi there! I follow a low histamine diet that Cycling Lady brought to my attention a long time ago. Citrus fruits and their juices are histamine releasing foods. High histamine levels can cause hives just like in an allergic reaction. Here's a helpful site: https://www.histaminein...

Thank you! Exactly!

No, no, no! Don't cut yourself off from your friends and social life because you feel you can't eat what everyone else is eating! I can't think of a single bar or restaurant I've been to where I haven't found something to eat. It may not always be what I would like to order/eat, but I'm not si...