No popular authors found.
Ads by Google:

Categories

No categories found.


Get Celiac.com's E-Newsletter





Ads by Google:


Follow / Share


  FOLLOW US:
Twitter Facebook Google Plus Pinterest RSS Podcast Email  Get Email Alerts
SHARE:

Popular Articles

No popular articles found.
Celiac.com Sponsors:

Association Analysis of the Extended MHC Region in Celiac Disease Implicates Multiple Gene Sites

Celiac.com 12/26/2012 - Currently, researchers have found forty separate gene sites that they associate with celiac disease. They classify all of these sies as "low-penetrance," with the exception of the high-risk genotypes in the HLA-DQA1 and HLA-DQB1 genes, which are necessary, but not sufficient to cause the disease.

Photo: CC--The Pale Side of InsomniaSo far, their efforts to find more such sites have been prevented by the strong effects from the known HLA loci and the genetically complex nature of the major histocompatibility complex (MHC).

A research team wanted to test the hypothesis that additional celiac disease gene sites exist within the extended major histocompatibility complex (xMHC).

The research team included Richard Ahn, Yuan Chun Ding, Joseph Murray, Alessio Fasano, Peter H. R. Green, Susan L. Neuhausen, and Chad Garner. They are variously affiliated with the Department of Epidemiology, University of California Irvine, Irvine, California, the Department of Population Sciences at eh Beckman Research Institute of City of Hope in Duarte, California, the Department of Medicine and Immunology at The Mayo Clinic in Rochester, Minnesota, the Center for Celiac Research at the University of Maryland School of Medicine in Baltimore, Maryland, and the Celiac Disease Center at Columbia University in New York, New York.

To follow up on the hypothesis, they looked at a collection of single nucleotide polymorphisms, frequently called SNPs (pronounced “snips”), which are the most common type of genetic variation among people.

Ads by Google:

For their study, the research team analyzed a set of 1898 SNPs for association across the 7.6 Mb xMHC region in 1668 patients with confirmed celiac disease, and 517 non-celiac control subjects.

The researchers used what is called conditional recursive partitioning to create a marker of known HLA-DQA1 and HLA-DQB1 high-risk genotypes that was included in the association analysis to account for their effects.

After accounting for the known effects, they used a linkage disequilibrium-based grouping procedure to estimate the number of independent celiac disease loci present in the xMHC. They found strong statistical evidence for four new independent celiac disease loci within the classic MHC region.

This was the first time researchers have conducted a comprehensive association analysis of the xMHC in celiac disease that specifically accounts for the known HLA disease genotypes and the genetic complexity of the region.

Source:

Celiac.com welcomes your comments below (registration is NOT required).












Related Articles

  • Multiple Common Variants for Celiac Disease Influencing Immune Gene Expression As part of an effort to investigate the possibility of multiple common variants for celiac disease influencing immune gene expression, a team of more than sixty scientists recently worked together to conduct a second-generation genome-wide association study (GWAS) of 4,533 individuals with clinically proven celiac disease, along with 10,750 control subjects.... [READ MORE]


3 Responses:

 
sufferer
Rating: ratingfullratingemptyratingemptyratingemptyratingempty Unrated
said this on
26 Dec 2012 7:29:10 PM PDT
Lots of big words and acronyms, but no content for sufferers. We need real news concerning celiac disease: how deep frying or sugar may lessen the effects, etc.

 
gluten free forever
Rating: ratingfullratingfullratingfullratingfullratingfull Unrated
said this on
31 Dec 2012 6:49:51 PM PDT
This research is very valuable for those of us who did not test DQ2 or DQ8, but have definite symptoms and suffer just as great. The medical community presently does not recognize other genomes as suspect and will not give the proper diagnosis. This helps with more extensive genome possibilities which will hopefully give the medical community more info that celiac disease is not limited to just HLA DQ2 or 8.

 
Emily
Rating: ratingfullratingfullratingfullratingfullratingfull Unrated
said this on
01 Jan 2013 9:06:24 AM PDT
Excellent line of research.




Rate this article and leave a comment:
Rating: * Poor Excellent
Your Name *: Email (private) *:




In Celiac.com's Forum Now:


I was just thinking the same thing!

And we have come a long way in the 4 years since this was written!

Spicely Organics lab certifies all their spices gluten-free. The turmeric and curry powder they have is safe, also Thai Kitchen Curry Paste is certified Gluten free....I like you do not trust the normal curry powders or most blends with it.

In 1978 Virginia Slims' magazine advertising spouted "You've Come A Long Way Baby". Well, in 2011 "WE" celiac/DH people can express those same words when talking about how far we have travelled since I was diagnosed as a brittle celiac/DH person 16 years ago. If the people with peanut allergies c...

I would be willing to bet that nothing changed in that product except the label. A bunch of companies seemed to have decided that they need to put "May contains allergens " on the everything to be safe. But I wouldn't buy it any longer.