Celiac Disease and Gluten-Free Diet Support
- Questions? Join our forum: Nearly 1 MILLION POSTS, and over 62,000 MEMBERS!
Follow / Share
|Get Email Alerts|
- Safe Gluten-Free Food List (Safe Ingredients)
- Unsafe Gluten-Free Food List (Unsafe Ingredients)
- Gluten-Free Alcoholic Beverages
- Celiac Disease Symptoms
- The Gluten-Free Diet 101 - A Beginner's Guide to Going Gluten-Free
- Interpretation of Celiac Disease Blood Test Results
- Is Buckwheat Flour Really Gluten-Free?
Celiac Disease with Mild Enteropathy is Not Mild Disease
Celiac.com 03/20/2013 - People with celiac disease all have some degree of damage to the small intestinal mucosa, ranging from lymphocytic duodenosis with normal villous structure to severe villous atrophy.
To determine whether the severity of mucosal lesions was associated with clinical and laboratory features of celiac disease, a team of researchers recently conducted a study on celiac disease with mild enteropathy.
The researchers included B. Zanini, F. Caselani, A. Magni, D. Turini, A. Ferraresi, F. Lanzarotto, V. Villanacci, N. Carabellese, C. Ricci, A. Lanzini. They are affiliated with the Gastroenterology Unit at the University of Brescia in Brescia, Italy.
For their study, they compared demographic, clinical, and laboratory characteristics among patients with celiac disease who were classified based on the severity of duodenal lesions.
The team assessed data from 1408 adult celiac patients seen consecutively at an outside referral center since 1990. 1249 patients showed villous atrophy, while 159 showed mild enteropathy (n = 159).
Patients with villous atrophy, compared with mild enteropathy, showed similar rates of weight loss (17% vs 17%), gastrointestinal manifestations (70% vs 70%), extra-intestinal manifestations (66% vs 57%), and other associated conditions (19% vs 23%).
Compared to those with mild enteropathy, patients with villous atrophy had higher rates of anemia (42% vs 29%; P = .002), folate deficiency (75% vs 64%; P = .02), hypocholesterolemia (7% vs 2%; P = .02), hypocalcemia (26% vs 13%; P = .004), or hyperparathyroidism (45% vs 29%; P = .004).
Although osteopenia, osteoporosis, and test results that fall outside of laboratory parameters are common among celiac disease patients with mild enteropathy, they are more common and more severe in patients with villous atrophy.
Patients with villous atrophy and those with mild enteropathy showed similar rates of celiac-associated conditions. These results indicate that celiac disease with mild enteropathy is not mild disease, and definitely requires treatment with a gluten-free diet.
What do you think? Do you have celiac disease with mild enteropathy? Do you consider this to be a 'mild' condition? Share your comments below.
- Clin Gastroenterol Hepatol. 2012 Sep 27. pii: S1542-3565(12)01142-1. doi: 10.1016/j.cgh.2012.09.027.
Celiac.com welcomes your comments below (registration is NOT required).
How Common is Celiac Disease in Patients with Autoimmune Hepatitis?
Researchers don’t have much data on rates of celiac disease in patients with autoimmune hepatitis (AIH).... [READ MORE]
Higher Celiac Disease Risk in Children with Certain HLA Haplotypes
The presence of HLA haplotype DR3–DQ2 or DR4–DQ8 is associated with an increased risk of celiac disease.... [READ MORE]
Celiac Disease and the Enteropathy Associated with Common Variable Immunodeficiency
The enteropathy associated with common variable immunodeficiency (CVID) is the most common symptomatic primary antibody deficient syndrome, with an estimated prevalence of one in one-hundred thousand to one in fifty thousand.... [READ MORE]
Mothers with Untreated Celiac Disease Face a Higher Risk of Underweight and Early-term Births; No Risk for Moms on Gluten-free Diet
Women with celiac disease face greater risks for adverse pregnancy outcomes.... [READ MORE]
Jefferson Adams is a freelance writer living in San Francisco. His poems, essays and photographs have appeared in Antioch Review, Blue Mesa Review, CALIBAN, Hayden's Ferry Review, Huffington Post, the Mississippi Review, and Slate among others.
He is a member of both the National Writers Union, the International Federation of Journalists, and covers San Francisco Health News for Examiner.com.View all articles by Jefferson Adams
In Celiac.com's Forum Now:
Celiac.com Celiac Disease & Gluten-Free Diet Forum - All Activity