No popular authors found.
Ads by Google:

Categories

No categories found.


Get Celiac.com's E-Newsletter





Ads by Google:


Follow / Share


  FOLLOW US:
Twitter Facebook Google Plus Pinterest RSS Podcast Email  Get Email Alerts
SHARE:

Popular Articles

No popular articles found.
Celiac.com Sponsors:

Can Capsule Endoscopy Help to Diagnose Cases of Equivocal Celiac Disease in Adults?

Celiac.com 04/01/2013 - There haven't been many studies that evaluate the usefulness of capsule endoscopy in equivocal celiac disease. A team of researchers recently set out to conduct an evaluation of capsule endoscopy in adult celiac disease, and to assess its potential role in equivocal cases of celiac disease compared with patients with biopsy-proven and serology-proven celiac disease who have persisting symptoms.

Photo: CC-- Capt. KodakThe research team included M. Kurien, K.E. Evans, I. Aziz, R. Sidhu, K. Drew, T.L. Rogers, M.E. McAlindon, and D.S.Sanders. They are affiliated with the Department of Gastroenterology at Royal Hallamshire Hospital, Sheffield Teaching Hospitals NHS Foundation Trust in Sheffield, South Yorkshire, United Kingdom.

To determine the use of capsule endoscopy in patients with equivocal celiac disease, compared to patients with biopsy-proven and serology-proven celiac disease who have ongoing symptoms.

To do this, the team conduced a prospective cohort study of 62 patients with equivocal celiac disease and 69 patients with non-responsive celiac disease.

They measured outcome according to the diagnostic yield of capsule endoscopy in equivocal cases and accuracy of mucosal abnormality detection in patients with non-responsive celiac disease.

They found that the 62 cases of equivocal celiac disease could be divided into two subgroups: group A, with 32 cases of antibody-negative villous atrophy, and group B with 30 cases of Marsh 1-2 changes.

Ads by Google:

In group A, using capsule endoscopy, the team was able to diagnose celiac disease or Crohn's disease in 9 of 32 patients (28%), compared with just 2 of the 30 patients in group B (7%; P = .044).

In patients with persistent celiac disease symptoms, the team made
significant capsule endoscopy findings in 8 of 69 patients (12%), including 2 cases of enteropathy-associated lymphoma, 4 cases of type 1 refractory celiac disease, 1 polypoidal mass histologically confirmed to be a fibroepithelial polyp, and 1 case of ulcerative jejunitis.

This outcome was significantly lower than the diagnostic yield of capsule endoscopy in antibody-negative villous atrophy (P = .048).

It is important to remember that this study was restricted to a single clinic. That said, this is the first time that researchers have used capsule endoscopy to systematically evaluate equivocal celiac disease.

Because the diagnostic rates for capsule endoscopy in patients with antibody-negative villous atrophy are better than that of capsule endoscopy in patients with celiac disease with persisting symptoms, the researchers are encouraging the use of capsule endoscopy in equivocal cases, especially in cases where patients antibody-negative villous atrophy.

Source:

Celiac.com welcomes your comments below (registration is NOT required).












Related Articles



1 Response:

 
Donna
Rating: ratingfullratingfullratingfullratingfullratingfull Unrated
said this on
08 Apr 2013 11:52:02 PM PDT
Thank you for the information. Since bring diagnosed with Crohn's disease, every bit of detail is paramount and interesting.




Rate this article and leave a comment:
Rating: * Poor Excellent
Your Name *: Email (private) *:




In Celiac.com's Forum Now:


Forum Members, This is a follow up question to a link posted in this thread I have read the Patient Celiac site before but she noted the possible use of Losartan (Potassium) contributing to Villi Blunting? This concerns me because I am now taking Losartan for blood pressure. ...

A few more thoughts. I also join others in saying ditch anything with oats for at least a while, even if they are certified. For hot breakfasts, have quinoa or buckwheat instead.

Oh how awful, and it sounds like there may be a CQ deficit among your medical helpers!, CQ being curiosity quotient. But maybe they?re researching it. It?s very difficult for me, too, to understand when I?ve been glutened ? to narrow down the culprit, or even if there is a culprit. I haven?t...

You've had great suggestions from everyone! Okay, some random thoughts from me. 3 roommates.....wow!.....almost a guarantee of something going wrong daily. They can't be using loose gluten flour, not to make cakes or gravy or anything. Flour hangs in the air for hours to days. What you breat...

Where can I go besides Europe? Anyone know of cool WWOOFing farms that support celiacs? specifically in South America or Asia?