No popular authors found.
Ads by Google:

Categories

No categories found.


Get Celiac.com's E-Newsletter





Ads by Google:


Follow / Share


  FOLLOW US:
Twitter Facebook Google Plus Pinterest RSS Podcast Email  Get Email Alerts
SHARE:

Popular Articles

No popular articles found.
Celiac.com Sponsors:

Researchers Complete Genetic Study of Celiac, Five Other Autoimmune Diseases

Celiac.com 07/03/2013 - Researchers have completed a genetic study of six autoimmune diseases, including diabetes, the largest such study of human disease genetics to date. The study will help scientists in their efforts to uncover the causes of these diseases, which include autoimmune thyroid disease, celiac disease, Crohn’s disease, psoriasis, multiple sclerosis and type 1 diabetes.

Photo: CC-- Allen GathmanWhile currently unknown, the underlying causes of these conditions are believed to involve a complex combination of genetic and environmental factors. In each of the six diseases, the identified genetic variants explained only a proportion of the heritability.

Under one of the current major genetic disease hypotheses, the so called ‘rare-variant synthetic genome-wide association hypothesis,’ a small number of rare variants in risk genes are likely the major cause of the heritability of these conditions.

In their study, the research team used high-throughput sequencing techniques, in an effort to identify new genetic variants, including rare and potentially high risk variants, in 25 previously identified risk genes taken from a sample of nearly 42,000 patients.

Their data suggest that the genetic risk of these diseases more likely results from a complex interaction of hundreds of variants, each small on its own, but which, taken together impact the development of these six diseases.

Ads by Google:

They estimate that rare variants in these risk genes make up only about three per cent of the heritability of these conditions that can be explained by common variants.

The results, says lead study author David van Heel, suggest that "risk for these autoimmune diseases is not due to a few high-risk genetic variations." Rather, risk is likely due to a "random selection from many common genetic variants which each have a weak effect.”

This could mean that it will never be possible to accurately predict a person's risk of developing any of these six autoimmune diseases, simply because there are too many variables.

“However, the results do provide important information about the biological basis of these conditions and the pathways involved, which could lead to the identification new drug targets,” said van Heel.

Source:

Celiac.com welcomes your comments below (registration is NOT required).












Related Articles



2 Responses:

 
CeliacMom
Rating: ratingfullratingfullratingfullratingfullratingfull Unrated
said this on
09 Jul 2013 7:00:05 AM PDT
Thanks for explaining this, sounds complicated!

 
Kim

said this on
12 Jul 2013 7:14:44 AM PDT
Whats more complicated is I have Hypothroidism, Celiac disease, and Psoriasis... urgh




Rate this article and leave a comment:
Rating: * Poor Excellent
Your Name *: Email (private) *:




In Celiac.com's Forum Now:


Welcome. I think that the IgA and IgG tests are ordered as control tests for celiac disease testing. If in range (or close to it), the TTG IgA and the TTG IgG tests are considered to be valid (results accurate). Those tests also let a doctor know if there is an immune system issue. You are ta...

Hi, I'm trying to sort out my 11 year old daughter who has a lot of stomach pain and belching. Her IGG and IGA were both positive 203 and 68 (above 25 positive at this lab) her TTG was negative and her biopsy was negative. What does this mixed result mean? Thanks for you...

just realized I wasn't directly responding to you - response above and below this post I'm quoting

My Japanese speaking is a bit more advanced than that (though still basic) so I think you can hold back on the research for phrases or apps. Again, appreciate it. Will look into Amazon overnight- never even crossed my mind. Thank you!

Yeah it works, just try to be careful with and do rotate off it for good amounts of time, the addiction to is killer, and can make you manic, and crazy. I used to rely on it too much way back and getting off was nightmare.