No popular authors found.
Ads by Google:

Categories

No categories found.


Get Celiac.com's E-Newsletter





Ads by Google:


Follow / Share


  FOLLOW US:
Twitter Facebook Google Plus Pinterest RSS Podcast Email  Get Email Alerts
SHARE:

Popular Articles

No popular articles found.
Celiac.com Sponsors:

Is Non-Celiac Wheat Sensitivity Actually an Allergic Condition?

Non-celiac wheat sensitivity (NCWS) is a newly described clinical condition marked by symptoms which may affect the gastrointestinal tract, the nervous system, the skin, and other organs.

Photo: CC--mihecoThere is little data regarding the origins of NCWS, and it is likely that numerous factors influence the various clinical manifestations of the condition.

The one common thread in NCWS is wheat consumption. Symptoms disappear when wheat is eliminated from the diet, and reappear when wheat is consumed.

Looking into the possibility that their NCWS patients might in fact be suffering from non-immunoglobulin E (IgE)-mediated wheat allergy, a team of researchers conducted a review their own earlier data regarding NCWS, with a corresponding review of relevant medical literature on NCWS.

The research team included Antonio Carroccio, Pasquale Mansueto, Alberto D'Alcamo and Giuseppe Iacono. Together, they reviewed data on 276 patients diagnosed with NCWS by means of double-blind placebo-controlled (DBPC) wheat challenge.

Ads by Google:

They then examined data indicating a possible wheat allergy diagnosis, and reviewed other study data, along with the role of serum immunoglobulin G antibodies and the basophil activation assay in food allergy, and the histology findings in the food allergy diagnosis.

By comparing patients with NCWS and irritable bowel syndrome (IBS) against controls with non-IBS-related NCWS, the team determined that NCWS was marked by: food allergy in the pediatric age (0.01); coexistent atopic diseases (0.0001); positive serum anti-gliadin (0.0001) and anti-betalactoglobulin (0.001) antibodies; positive cytofluorimetric assay revealing in vitro basophil activation by food antigens (0.0001); and a presence of eosinophils in the intestinal mucosa biopsies (0.0001).

Patients with NCWS and multiple food sensitivity show several clinical, laboratory, and histological characteristics that suggest they might actually be suffering from non-IgE-mediated food allergy.

This is potentially very interesting news regarding NCWS, but the team does note that other pathogenic possibilities need to be considered and investigated before this can be confirmed.

Source:

Celiac.com welcomes your comments below (registration is NOT required).












Related Articles



1 Response:

 
Julie Rohrdanz
Rating: ratingfullratingfullratingfullratingfullratingempty Unrated
said this on
10 Aug 2014 5:20:13 AM PDT
I hope they continue with this. It would be nice to finally understand what the cause it. NCWS is often viewed as "not real" by many. But to be able to absolutely diagnose it would be terrific!




Rate this article and leave a comment:
Rating: * Poor Excellent
Your Name *: Email (private) *:




In Celiac.com's Forum Now:


Is your concern the social aspects of eating on the job, or not always feeling well enough to get out the door? I'm in health care, and just happened to be in home care when I was diagnosed. It actually works well, as I make my own hours, and can reschedule visits as need be. I would t...

Can you tolerate nut milks? I find macadamia milk the gentlest on my stomach. The only brand I've seen here in the US is Milkadamia, and it comes sweetened or not, and fortified with some vitamins. I think this brand is from Australia. Or you could make your own. As for time, it can take awh...

Thank you for your response! Again I am pretty sure my doctor did all these checks however I will definitely check to make sure and take the necessary actions if not. It just feels like a never ending run of doctor appointments and blood tests at the moment and the whole thing really did come as ...

Is aroy d milk gluten free?I couldnt find an information on its package,it says it doesn't have any additives.It's full fat and sold in a bpa free carton box.Anyone tried it?

Thank you so much for your reply, it has really helped! Your feedback on the grieving side has really comforted me to know I am not the only one and that it will get better. I am not always upset and sometimes I feel optimistic but occasionally it really just does get overwhelming especially at t...