Jump to content
This site uses cookies. Continued use is acceptance of our Terms of Use and Privacy Policy. More Info... ×
  • Welcome to Celiac.com!

    You have found your celiac tribe! Join us and ask questions in our forum, share your story, and connect with others.




  • Celiac.com Sponsor (A1):



    Celiac.com Sponsor (A1-M):


  • Get Celiac.com Updates:
    Where Your Contribution Counts!
    eNewsletter
    Support Us!
  • Record is Archived

    This article is now archived and is closed to further replies.

    Jefferson Adams
    Jefferson Adams

    BioLineRX Announces Trial of New Celiac Drug

    Reviewed and edited by a celiac disease expert.
    BioLineRX Announces Trial of New Celiac Drug - Image: Public Media--BioLineRX
    Caption: Image: Public Media--BioLineRX

    Celiac.com 01/31/2014 - Drug company BioLineRx has announced trials of BL-7010, a drug for treating celiac disease. BL-7010 is a new, non-absorbable, orally available polymer with a high affinity for gliadins, the immunogenic proteins present in gluten that cause celiac disease.

    Image: Public Media--BioLineRXBL-7010 is intended to treat celiac disease by sequestering and effectively masking gliadins from enzymatic degradation and preventing the formation of immunogenic peptides that trigger the classic adverse immune reaction.

    Celiac.com Sponsor (A12):
    The BL-7010 is then excreted with gliadin from the digestive tract, preventing the absorption of gliadin into the blood.

    The overall effect is to significantly reduce the immune response triggered by gluten. According to BioLineRX, pre-clinical studies have shown BL-7010 to be both safety and effective.

    BioLineRX's Phase 1/2 study is a two-part, both single and repeated, double-blind, placebo-controlled, dose escalation study of BL-7010 in up to 32 patients.

    The main goal is to gauge the safety of single and repeated increasing doses of BL-7010 in well-controlled celiac disease patients.

    They also hope to assess the results of systemic exposure, if any, of BL-7010 in the study patients.

    Source:

    • Open Original Shared Link


    User Feedback

    Recommended Comments

    Guest Jacqie

    Why in the world would I want to take a drug (which will definitely have side effects - they all do) to "treat" my celiac disease, when I have a proven, harmless, effective, inexpensive treatment already at my fingertips? I have no desire to EVER eat gluten again. I am perfectly happy being gluten free and I eat wholesome, delicious foods that nourish my body instead of destroying it. Recently, I was asked if I wanted to participate in clinical trials for a new "vaccine" for celiac disease. NO! Why would I take that kind of risk when I am already doing the best thing I can do for myself?

    Link to comment
    Share on other sites
    Guest Kristen

    Posted

    Why in the world would I want to take a drug (which will definitely have side effects - they all do) to "treat" my celiac disease, when I have a proven, harmless, effective, inexpensive treatment already at my fingertips? I have no desire to EVER eat gluten again. I am perfectly happy being gluten free and I eat wholesome, delicious foods that nourish my body instead of destroying it. Recently, I was asked if I wanted to participate in clinical trials for a new "vaccine" for celiac disease. NO! Why would I take that kind of risk when I am already doing the best thing I can do for myself?

    Why, you ask, Jacqie? Because this could change the lives of so many of us.

     

    I know, for myself, this would not change my overall eating habits. I too am (mostly) happy with my current diet. I eat very well also, and was never a big bread person. The biggest loss for me was the dairy, but I've made my peace with it.

     

    However, all that said I know there are a lot of people like me, who are so very limited in how they can function on a social level. For me, a cross-contamination event has a downtime of weeks to months. The pain and recovery are so intense and long lasting that eating out anywhere is simply not worth the risk. This is incredibly limiting. I cannot simply go out and order off the gluten free menu. There is no trust there. To get that freedom back, to be able to go (anywhere, vacations etc) with my spouse and not have to worry about how we are going to feed me, would be life changing. To order out and not worry about cross contamination. Amazing.

    Yes, there will likely be side effects, but until we know more, I would not completely discount the idea.

    Link to comment
    Share on other sites
    Guest kwix

    I have a very different opinion than Jacqie above. I spent the first 50 years of my life avoiding bread, pasta and such...anyway, I have no desire to ever eat that stuff again.

     

    But I long for a time I can just eat out with others without poring over every detail of a menu and interrogating waiters for ten minutes. Or get some occasional Chinese carry-out. Or travel without constant planning, worrying and a carry-on full of gluten-free food. Or just walk into any hole-in the wall ethnic restaurant and order something (obviously non-wheaty) I've never heard of, like I used to when I was a food blogger...

    Link to comment
    Share on other sites
    Guest Peggy Worley

    Posted

    Why in the world would I want to take a drug (which will definitely have side effects - they all do) to "treat" my celiac disease, when I have a proven, harmless, effective, inexpensive treatment already at my fingertips? I have no desire to EVER eat gluten again. I am perfectly happy being gluten free and I eat wholesome, delicious foods that nourish my body instead of destroying it. Recently, I was asked if I wanted to participate in clinical trials for a new "vaccine" for celiac disease. NO! Why would I take that kind of risk when I am already doing the best thing I can do for myself?

    I totally agree with you. When I first started "gluten free" it was really hard to do--now two years later I realize it's the way you are supposed to eat anyway!! Just go with fresh meat, fruits and veggies. I have kept my weight down to perfect for 2 years. I wouldn't change a thing.

    Link to comment
    Share on other sites
    Guest Heather

    Posted

    Why in the world would I want to take a drug (which will definitely have side effects - they all do) to "treat" my celiac disease, when I have a proven, harmless, effective, inexpensive treatment already at my fingertips? I have no desire to EVER eat gluten again. I am perfectly happy being gluten free and I eat wholesome, delicious foods that nourish my body instead of destroying it. Recently, I was asked if I wanted to participate in clinical trials for a new "vaccine" for celiac disease. NO! Why would I take that kind of risk when I am already doing the best thing I can do for myself?

    I wouldn't want to participate in a trial, either. But, if the drug is eventually proven safe and effective and could be taken to eliminate cross-contamination risks (like when eating out), I'm all for it!

    Link to comment
    Share on other sites
    Guest Gus
    Why in the world would I want to take a drug (which will definitely have side effects - they all do) to "treat" my celiac disease, when I have a proven, harmless, effective, inexpensive treatment already at my fingertips? I have no desire to EVER eat gluten again. I am perfectly happy being gluten free and I eat wholesome, delicious foods that nourish my body instead of destroying it. Recently, I was asked if I wanted to participate in clinical trials for a new "vaccine" for celiac disease. NO! Why would I take that kind of risk when I am already doing the best thing I can do for myself?

    Because the gluten free diet is much more expensive than a regular diet there are so many people around the world with not enough economic resources to achieve a complete gluten free diet.

    Link to comment
    Share on other sites


    Guest
    This is now closed for further comments

  • Get Celiac.com Updates:
    Help Celiac.com:
    Donate
  • About Me

    Jefferson Adams

    Jefferson Adams is Celiac.com's senior writer and Digital Content Director. He earned his B.A. and M.F.A. at Arizona State University. His articles, essays, poems, stories and book reviews have appeared in numerous magazines, journals, and websites, including North American Project, Antioch Review, Caliban, Mississippi Review, Slate, and more. He is the author of more than 2,500 articles on celiac disease. His university coursework includes studies in science, scientific methodology, biology, anatomy, physiology, medicine, logic, and advanced research. He previously devised health and medical content for Colgate, Dove, Pfizer, Sharecare, Walgreens, and more. Jefferson has spoken about celiac disease to the media, including an appearance on the KQED radio show Forum, and is the editor of numerous books, including "Cereal Killers" by Scott Adams and Ron Hoggan, Ed.D.

    >VIEW ALL ARTICLES BY JEFFERSON ADAMS

     


  • Celiac.com Sponsor (A17):
    Celiac.com Sponsor (A17):





    Celiac.com Sponsors (A17-M):




  • Related Articles

    Jefferson Adams
    Celiac.com 03/23/2011 - A group of researchers in India recently conducted a community-based study on the prevalence of celiac disease in the northern part of India.
    The research group included Govind K Makharia, Anil K Verma, Ritvik Amarchand, Shinjini Bhatnagar, Prasenjit Das, Anil Goswami, Vidyut Bhatia, Vineet Ahuja, Siddhartha Datta Gupta and Krishnan Anand.
    They are affiliated with the Departments of Gastroenterology and Human Nutrition, and Pediatrics and Pathology at the Centre for Community Medicine of the All India Institute of Medical Sciences in New Delhi.
    Worldwide celiac disease rates are estimated at about 1%, but the disease is thought to be uncommon in both India and Asia. However, there has generally been a lack of study data on the actual prevalence of celiac...


    Jefferson Adams
    Celiac.com 03/28/2011 - While rates of diagnosed celiac disease are less than 1 in 2,000 in the United States, screening studies in European and other populations have shown a much higher prevalence.
    A team of researchers recently set out to assess rates of celiac disease and the benefits of screening in the general adult population in certain geographically isolated areas.
    The research team included Kent D. Katz MD, Shahrooz Rashtak MD, Brian D. Lahr BS, MS, L. Joseph Melton III MD, Patricia K. Krause BS, MBA, Kristine Maggi PA-C, Nicholas J. Talley MD, PhD, and Joseph A. Murray MD.
    They are affiliated variously with the Wyoming Medical Center in Casper, Wyoming, the Department of Dermatology, the Division of Gastroenterology and Hepatology of the Department of Internal Medicine...


    Jefferson Adams
    Celiac.com 12/25/2013 - At present, the number of reported celiac disease cases is extremely low in China. 
    Until recently, celiac disease was considered to be rare in China. A team of researchers recently set out to compile an accurate estimate of rates of celiac disease in China.
    The research team included Juanli Yuan, Jinyan Gao, Xin Li, Fahui Liu, Cisca Wijmenga, Hongbing Chen, and Luud J. W. J. Gilissen. They are variously affiliated with the State Key Laboratory of Food Science and Technology, the College of Pharmaceutical Sciences, and the School of Life Sciences and Food Engineering, at Nanchang University in Nanchang, China, the Department of Genetics at the University Medical Centre Groningen ofUniversity of Groningen in Groningen, The Netherlands, with the Sino-German ...


    Jefferson Adams
    06/04/2014 - A Swedish research team study of nearly four decades of population-based data shows that rates of celiac disease are rising in most age groups of children.
    The research team included Fredinah Namatovu, Olof Sandström, Cecilia Olsson, Marie Lindkvist, and Anneli Ivarsson. They are variously affiliated with the Department of Public Health and Clinical Medicine, Epidemiology and Global Health, the Department of Clinical Sciences, Paediatrics, and the Department of Food and Nutrition, all at Umeå University, in Umeå, Sweden.
    In order to assess variations by age, sex and birth cohort, and to determine the clinical impact of these changes, their research team recently looked at rates of biopsy-proven celiac disease in children in Sweden over a 36-year period. The team us...


  • Recent Activity

    1. - Julie Riordan replied to Julie Riordan's topic in Traveling with Celiac Disease
      3

      Any ideas for travelling

    2. - trents replied to SuzanneL's topic in Celiac Disease Pre-Diagnosis, Testing & Symptoms
      1

      Weak Positive Test

    3. - SuzanneL posted a topic in Celiac Disease Pre-Diagnosis, Testing & Symptoms
      1

      Weak Positive Test

    4. - Scott Adams replied to Braver101's topic in Coping with Celiac Disease
      2

      Constant sweating with celiac disease

    5. - Scott Adams replied to Julie Riordan's topic in Traveling with Celiac Disease
      3

      Any ideas for travelling


  • Celiac.com Sponsor (A19):



  • Member Statistics

    • Total Members
      120,495
    • Most Online (within 30 mins)
      7,748

    Zofosho
    Newest Member
    Zofosho
    Joined

  • Celiac.com Sponsor (A20):


  • Forum Statistics

    • Total Topics
      120.2k
    • Total Posts
      1m

  • Celiac.com Sponsor (A22):





  • Celiac.com Sponsor (A21):



  • Popular Now

    • JustGemi
    • Linedancegal
    • Hannah24
      9
    • jessiemariecar
    • Rhonda H
  • Popular Articles

    • Scott Adams
    • Scott Adams
    • Scott Adams
    • Scott Adams
    • Scott Adams
  • Upcoming Events

×
×
  • Create New...