No popular authors found.
Ads by Google:

Categories

No categories found.


Get Celiac.com's E-Newsletter





Ads by Google:


Follow / Share


  FOLLOW US:
Twitter Facebook Google Plus Pinterest RSS Podcast Email  Get Email Alerts
SHARE:

Popular Articles

No popular articles found.
Celiac.com Sponsors:

Higher Hip Fracture Risk in Celiac Patients with Villous Atrophy

Celiac.com 02/19/2014 - Celiac disease have a greater risk of bone fracture than non-celiacs; a risk that persists after diagnosis. Also a substantial number of celiac patients display signs of persistent villous atrophy on follow-up biopsy.

Photo: Wikimedia Commons--HeatherA team of researchers recently set out to determine whether persistent villous atrophy impacts long-term fracture risk. The research team included Benjamin Lebwohl, Karl Michaëlsson, Peter H. R. Green and Jonas F. Ludvigsson. They are variously affiliated with the Celiac Disease Center, Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York; the Clinical Epidemiology Unit of the Department of Medicine at Karolinska University Hospital and Karolinska Institutet in Stockholm, Sweden; the Department of Surgical Sciences, Section of Orthopaedics at Uppsala University in Upsalla Sweden; and Department of Pediatrics at Örebro University Hospital in Örebro, Sweden.

First, the team identified all patients in Sweden with histological evidence of celiac disease who underwent a follow-up biopsy and compared patients with persistent villous atrophy with those with mucosal healing. The team then recorded data for all known general fractures; for likely osteoporotic fractures (of hip, distal forearm, thoracic and lumbar spine, or proximal humerus); and all known hip fractures.

Follow-up biopsies showed villous atrophy in 43% of the 7,146 patients. The results showed no significant connection between persistent villous atrophy and overall fractures.

Ads by Google:

The hazard ratio (HR) for persistent villous atrophy compared with those with healing was 0.93, with a 95% confidence interval (CI 0.82–1.06). Nor was there a connection between persistent villous atrophy and likely osteoporotic fractures (HR 1.11, 95% CI 0.84–1.46).

Results did show that persistent villous atrophy was connected with an increased risk of hip fracture (HR 1.67, 95% CI 1.05–2.66). The risk of hip fracture rose in relation to the degree of villous atrophy; the more villous atrophy, the higher the risk of hip fracture.

Overall, HR for partial villous atrophy compared with those with healing was 1.70, with a 95% CI 0.82–3.49 (HR for subtotal/total villous atrophy compared with those with healing 2.16, 95% CI 1.06–4.41).
The results indicate that persistent villous atrophy on follow-up biopsy can be used to predict the risk of hip fracture in patients with celiac disease.

The connection between persistent villous atrophy and hip fractures, but not fractures overall, implies that the increased fracture risk is due to thinner sc tissue, and fall or trauma.

Source:

Celiac.com welcomes your comments below (registration is NOT required).












Related Articles



Comments




Rate this article and leave a comment:
Rating: * Poor Excellent
Your Name *: Email (private) *:




In Celiac.com's Forum Now:


Some people will always test negative on the blood test, odd and rare but it happens. You also have to be eating gluten on a daily basis for the antibodies to show up for it in the test for at least 12 weeks. You can follow up with a endoscope and biopsy, if your having gut issues this might be a...

I have a friend who reacts to raw oranges, apples, and bananas. Funny thing is they are fine with cooked foods using them and pasturized orange juice. Some odd food allergy that gets broken down with heat. SIDE NOTE. I just reintroduced iceberg lettuce, and romaine after not having any in 4 ...

I had to research today from last night's reaction. Never thought oj would be a problem. I see from past posts some have had concerns about orange juice . I've joined the club. Myself and DS are reacting to something in pure premium. Just wanted to share info I found in case one day someon...

Hi all, first time posting here. After years of feeling chronically exhausted, depressed, irritable, bloated (the list goes on and on...) and with a family history of autoimmune disorders, I finally convinced my doctor to test for Celiac and autoimmune disorders. All my results came back neg...

I have not called his doctor yet. He is on holyday and i realy dont want to talk to any other doctor since my experience is that they are not taking the whole thing serious. The only doctor we trust is the new one, but he is on holyday... We will call him as soon as he is back. So for now we have...