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Diverse Gut Flora Hold Interest for Celiac Disease Researchers

Celiac.com 03/17/2014 - Researchers know a great deal about the function of human digestive proteases in gluten proteins, but they know very little about the role of intestinal microbes in metabolizing those proteins.

Photo: CC--Janoma.clA team of researchers recently set out to examine the isolation and characterization of human gut bacteria involved in the metabolizing gluten proteins.

The researchers include Alberto Caminero, Alexandra R. Herrán, Esther Nistal, Jenifer Pérez-Andrés, Luis Vaquero, Santiago Vivas, José María G. Ruiz de Morales, Silvia M. Albillos, and Javier Casqueiro.

They are variously affiliated with the Instituto de Biología Molecular, Genómica y Proteómica (INBIOMIC), and the Instituto de Biomedicina (IBIOMED) at the Campus de Vegazana of the Universidad de León, with the Área de Microbiología, Facultad de Biología y Ciencias Ambientales at the Universidad de León, with the Departamento de Inmunología y Gastroenterología, Hospital de León, León, Spain, and with the Instituto de Biotecnología (INBIOTEC) de León, all in León, Spain.

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For their study, the team cultured 22 human fecal samples, with gluten as the principal nitrogen source, and isolated 144 strains belonging to 35 bacterial species that may play a role in gluten metabolism in the human gut.

They found that 94 of the isolated strains were able to metabolize gluten, 61 strains showed an extracellular proteolytic activity against gluten proteins, while several strains showed a peptidasic activity toward the 33-mer peptide, which is an known peptide trigger in celiac disease patients.

Most of the isolated strains belong to the phyla Firmicutes and Actinobacteria, mainly from the genera Lactobacillus, Streptococcus, Staphylococcus, Clostridium and Bifidobacterium.

They found that the human gut hosts a wide variety of bacteria capable of using gluten proteins and peptides as nutrients. These bacteria could play an important role in gluten metabolism and could offer promising new treatment possibilities for celiac disease.

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1 Response:

 
brad
Rating: ratingfullratingfullratingfullratingfullratingfull Unrated
said this on
26 Mar 2014 6:56:04 AM PDT
As a celiac person of 10 years I can only hope research will someday shed light and offer even a partial cure....




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Those labs do not look like celiac tests. The first three MIGHT just be measuring total antibody levels of the three different classes, but on the very right it has IgA Serp (Serp cut off?) and I don't know what the Serp is referring to. The first column is the test name, the second column your value, the third column the units of measure, the fourth column the normal range. The first one is a tiny bit low, all the rest in the normal range.

Since this post is going around again, I thought I would add my recent experience at Rudy's. The staff was very helpful and accommodating. I ordered my family's food first put it on a tray and then ordered mine separately. I ordered only chicken and turkey. The staff changed gloves and used a new cutting board and knife. My server washed his hands, wiped down the scale and put my meat separately into a tray. I washed my hands before I ate. I did not eat any of the side and brought my own fruit to go with it. Since I don't get immediate symptoms, I can't tell you if that was enough. But, their meat (except the pork - maybe ) is gluten free. I think I did everything I can to avoid CC and the staff was extremely helpful . This is the only restaurant I have eaten at in 4 months if that tells you anything. I love Rudy's!!!

I got my script from the doc... it's for total IGA and TTG-IGA. Guess that's a good start? It also says "fasting" on the requisition, do I really need to be?

Something that's always weirded me out since I became somewhat non-responsive on repeat biopsies: I don't get colds anymore. Ever. I used to get maybe 5 a year ? standard stuff. Nothing in the past 3 years. I get a lot of sleep these days, but still. My girlfriend gets sick; I do not. Anyone else find their common transient illnesses take a strange turn after diagnosis? I hypothesize having an abnormal/overactive immune system might take down common bugs hard, but I also assume it's far more complicated than that.

Hello, Has anyone ever heard of a celiac diagnosis through an ultrasound? I have a friend who had an ultrasound for diverticulitis issues and the dr said he also had celiac disease. No blood test, no endoscopy. I don't think he wants to make this life change in his diet without knowing for sure.