No popular authors found.


Get Celiac.com's E-Newsletter

Categories

No categories found.







Ads by Google:


Questions? Join Our Forum:
~1 Million Posts
& Over 66,000 Members!



SHARE THIS PAGE:
Celiac.com Sponsors:

Evidence Supports Role for Autoantibodies to Heat Shock Protein 60, 70, & 90 in Dermatitis Herpetiformis

Celiac.com 04/14/2014 - Exposure to stressful stimuli, such as inflammation, cause cells to up-regulate heat shock proteins (Hsp), which are highly conserved immunomodulatory molecules. Research points to Hsp involvement in numerous autoimmune diseases, including autoimmune bullous diseases and celiac disease.

Photo: Wiki Media Commons--endofskullTo better understand the role of Hsp in autoimmune bullous diseases, a research team conducted the first investigation of the humoral autoimmune response to Hsp40, Hsp60, Hsp70, and Hsp90 in patients with dermatitis herpetiformis (DH; n = 26), bullous pemphigoid (BP; n = 23), and pemphigus vulgaris (PV; n = 16), the first representing a cutaneous manifestation of celiac disease.

The research team included Kasperkiewicz M1, Tukaj S, Gembicki AJ, Silló P, Görög A, Zillikens D, Kárpáti S. They are affiliated with the Department of Dermatology at the University of Lübeck in Lübeck, Germany.

Ads by Google:

In patients with active BP and PV, serum levels of autoantibodies against these Hsp matched the healthy control subjects (n = 9-14), while circulating autoantibodies against Hsp60, Hsp70, and Hsp90 increased at the active disease stage of DH.

Further analysis showed that in patients who adopt a gluten-free diet, these anti-Hsp autoantibodies decreased in relation to serum autoantibodies against epidermal and tissue transglutaminase during remission of skin lesions.

Larger groups of patients must be studied to confirm these findings, but these results indicate that autoantibodies against Hsp60, Hsp70, and Hsp90 play a key role in the development and maintenance of DH, possibly also in the underlying celiac disease, and may be important in
potentially undiscovered disease biomarkers.

Source:

Celiac.com welcomes your comments below (registration is NOT required).












Related Articles



Comments




Rate this article and leave a comment:
Rating: * Poor Excellent
Your Name *: Email (private) *:




In Celiac.com's Forum Now:


An autoimmune disease can occur when the body's immune system mistakenly perceives a nonthreatening substance. In the case of people with celiac disease, gluten (a protein found in wheat, barley, rye, and oats) is seen as a foreign invader and is attacked by the immune system. This immune system ...

Might consider my approach of a dairy free keto diet with very limited meat intake. I live off of omelettes with veggies, veggie stir fries nut based breads, nut butters, seeds, avocados, coconut, coconut wraps, nut based milks and cheeses instead of dairy, and I tend to have Kal nutritional yeas...

Thank u for replying, My gp said the high normal is 10 and I am 41. Waiting to have my biopsy done. Have been so Ill since last December with lots of neurological problems have had brain mri and have a small lesion on my brain but not necciserily connected to ms but have to have a repeat scan. Af...

Well, while not being a dairy product for Psoriatic people we are very limited to meat products so better option for me would be vegan.

Oh, the description said it was crispy but didn't realize it would be hard, what about this one? https://www.walmart.com/ip/4C-Gluten-Free-Plain-Crumbs-12-oz/39096467?wmlspartner=wlpa&adid=22222222227026826600&wl0=&wl1=g&wl2=c&wl3=43010521232&wl4=aud-310687321802:pla-81548181392&wl5=9004416&...