Celiac Disease and Gluten-Free Diet Support
- Questions? Join our forum: Nearly 1 MILLION POSTS, and over 62,000 MEMBERS!
Follow / Share
|Get Email Alerts|
- Safe Gluten-Free Food List (Safe Ingredients)
- Unsafe Gluten-Free Food List (Unsafe Ingredients)
- Gluten-Free Alcoholic Beverages
- Celiac Disease Symptoms
- The Gluten-Free Diet 101 - A Beginner's Guide to Going Gluten-Free
- Interpretation of Celiac Disease Blood Test Results
- Is Buckwheat Flour Really Gluten-Free?
Can Steroids Help Treat Celiac Disease?
The team included Shalimar, P. Das, V. Sreenivas, S. Datta Gupta, S.K. Panda, and G.K. Makharia. They are with the Department of Gastroenterology and Human Nutrition at the All India Institute of Medical Sciences in Ansari Nagar in New Delhi, India.
For their pilot randomized, controlled trial, the team looked at thirty-three untreated patients with celiac disease. They randomly assigned 17 of them to a gluten-free diet alone, and the other 16 to a gluten-free diet + prednisolone. Gluten intake was 1 mg/kg for 4 weeks.
The team stained all biopsies for markers of intrinsic apoptotic pathway (AIF, H2AX, p53), common apoptotic pathway (CC3, M30), apoptotic inhibitors (XIAP, Bcl2), and epithelial proliferation (Ki-67). They then compared apoptotic (AI) and proliferation indices (PI).
Initial duodenal biopsies showed the end apoptotic products H2AX and M30 to be markedly higher.
After prednisolone withdrawal, there was overexpression of H2AX, CC3, and p53 in the latter group. In comparison with those treated with only GFD, patients treated with prednisolone showed suppression of mucosal PI, which started rising again after withdrawal of prednisolone.
The take away here is that a short course of prednisolone quickly suppresses apoptosis. However, it also suppresses epithelial regeneration, an so should be used only for a short time, if at all.
Celiac.com welcomes your comments below (registration is NOT required).
30-Year Study Shows Duodenal Screening Biopsies Help Detect Adult Celiac Disease
Data from blood studies suggest that about 1% or so of North Americans have celiac disease.... [READ MORE]
Using Endocytoscopy to Perform Live, Real-time Imaging of Human Duodenal Mucosal Structures in Celiac Disease
Proper clinical diagnosis of celiac disease
still relies on confirmation of histological evidence of villous
atrophy via biopsy.... [READ MORE]
Lesser Degrees of Villous Atrophy Correspond to a Greater Frequency of Seronegative Celiac Disease
A recent study published in
the journal Digestive Diseases and Sciences indicates that lesser degrees
of villous atrophy correspond to seronegative celiac disease.... [READ MORE]
Bile Acid Malabsorption Related to Chronic Diarrhea
Eur J Gastroenterol
Hepatol 2000;12:541-547.... [READ MORE]
Jefferson Adams is a freelance writer living in San Francisco. His poems, essays and photographs have appeared in Antioch Review, Blue Mesa Review, CALIBAN, Hayden's Ferry Review, Huffington Post, the Mississippi Review, and Slate among others.
He is a member of both the National Writers Union, the International Federation of Journalists, and covers San Francisco Health News for Examiner.com.View all articles by Jefferson Adams
In Celiac.com's Forum Now:
Celiac.com Celiac Disease & Gluten-Free Diet Forum - All Activity