No popular authors found.


Get Celiac.com's E-Newsletter

Categories

No categories found.







Ads by Google:


Questions? Join Our Forum:
~1 Million Posts
& Over 66,000 Members!



SHARE THIS PAGE:
Celiac.com Sponsors:

Do People with Non-celiac Gluten Sensitivity Improve on Gluten-free Diets?

Celiac.com 07/25/2014 - People with non-celiac gluten sensitivity (NCGS) do not have celiac disease, but their symptoms improve when they are placed on gluten-free diets.

Photo: Wikimedia CommonsA research team set out to study the specific effects of gluten after dietary reduction of fermentable, poorly absorbed, short-chain carbohydrates (fermentable, oligo-, di-, monosaccharides, and polyols [FODMAPs]) in subjects believed to have NCGS. The study team included J.R. Biesiekierski of the Department of Gastroenterology, Eastern Health Clinical School, Monash University, Box Hill, Victoria, Australia, and colleagues S.L. Peters, E.D. Newnham, O. Rosella, J.G. Muir, and P.R. Gibson.

They conducted a double-blind cross-over trial on 31 women and 6 men, aged 24-61, with NCGS and irritable bowel syndrome (based on Rome III criteria), but not celiac disease. Researchers randomly assigned participants to groups given a 2-week diet of reduced FODMAPs. Participants were then placed on high-gluten (16 g gluten/d), low-gluten (2 g gluten/d and 14 g whey protein/d), or control (16 g whey protein/d) diets for 1 week, followed by a washout period of at least 2 weeks.

The team measured serum and fecal markers of intestinal inflammation/injury and immune activation, and indices of fatigue. Twenty-two participants were then given either gluten (16 g/d), whey (16 g/d), or control (no additional protein) diets for 3 days. The team evaluated symptoms using visual analogue scales.

Ads by Google:

Every patient experienced significant improvement in gastrointestinal symptoms during reduced FODMAP intake. Conversely, every patient experienced significantly worse symptoms when their diets included gluten or whey protein. The team observed gluten-specific effects in just 8% of participants. They saw no diet-specific changes in any biomarker.

During the 3-day re-challenge, participants' symptoms increased by similar levels among groups. Gluten-specific gastrointestinal effects were not reproduced.

The end result for this placebo-controlled, cross-over re-challenge study showed no evidence of specific or dose-dependent effects of gluten in patients with NCGS placed on diets low in FODMAPs. The translation is that the team saw no effects of gluten in patients with self-reported non-celiac gluten sensitivity after dietary reduction of fermentable, poorly absorbed, short-chain carbohydrates.

Source:

 

Celiac.com welcomes your comments below (registration is NOT required).












Related Articles



1 Response:

 
Julie Rohrdanz
Rating: ratingfullratingfullratingfullratingemptyratingempty Unrated
said this on
10 Aug 2014 5:14:40 AM PST
It is important to understand why people who suffer from non-celiac gluten sensitivity. I do feel that this article though, conveys that non-celiac gluten sensitivity is not real. I'd like the scientific community to really pursue what specifically about a gluten free diet eliminates the symptoms. The critics can say NCGS doesnt exist. In the end, for me, it doesn't matter if it is another protein or a carb in wheat, rye, barley. I know that removing gluten from my diet changed my life, I was very sick. Exposure to gluten foods brings the myriad of symptoms back. Rather than debunking gluten, maybe more research could be done to show why the gluten free diet works (other than gluten).




Rate this article and leave a comment:
Rating: * Poor Excellent
Your Name *: Email (private) *:




In Celiac.com's Forum Now:


Maybe some gentle or beginners slow flow yoga? Something that will move slowly

I fixed it

I'm sorry as this was posted in the wrong forum.

I feel better in some ways. But I still get tired and I still have some stressful people in my life. I think I'm in this bad cycle and I'm wondering what could break me out of it. What I used to like, light running, cycling, yoga, pilates, light basketball just for fun - even by myself is good, h...

Not related to a food necessarily, but more like when I finally get some time to collect my thoughts and the world stops spinning I get a sense of - suddenly seeing the larger picture of what's happened with me for the last year or even my whole life. Instead of just a quiet reflection feeling li...