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Does Benicar Trigger Celiac-like Gut Symptoms?

Celiac.com 07/09/2014 - Does the blood pressure medication Benicar (Olmesartan medoxomil) trigger celiac-like gut symptoms?

Image: Wikimedia CommonsThe law firm Levin, Papantonio has filed a lawsuit claiming just that, on behalf of a Texas man who allegedly developed a rare gastrointestinal condition known as sprue-like enteropathy while taking Benicar.

According to the complaint, Benicar caused the plaintiff to suffer severe gastrointestinal symptoms, including chronic diarrhea, weight loss, malnutrition, and dehydration. These symptoms are commonly associated with a rare sprue-like enteropathy.

The lawsuit comes as Benicar faces scrutiny following a Mayo Clinic study linking the popular drug to rare sprue-like enteropathy in users.

The connection between Benicar and the sprue-like enteropathy symptoms was first noted by Mayo Clinic gastroenterologist, Dr. Joseph Murray, after he observed two patients taking Benicar experience relief from symptoms thought to be associated with Celiac disease. Upon discontinuing the use of Benicar, the gastrointestinal symptoms vanished.

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Dr. Murray then conducted a three-year study of 22 people who experienced celiac-like symptoms while taking Benicar. He found that 14 of those patients had symptoms so severe that hospitalization was required.

Moreover, none of the 22 original patients responded to a gluten-free diet, and none showed any detectable levels of tissue transglutaminase in the blood, which would point to celiac disease.

After discontinuing the Benicar treatments, the intestinal symptoms disappeared in each of the 22 patients, and they all regained lost weight.

In 2013, in keeping with Dr. Murray’s findings, the U.S. Food and Drug Administration changed Benicar’s label to include a warning that the drug may trigger sprue-like enteropathy and symptoms similar to celiac disease.

If you think you may have suffered adverse effects from Benicar, check with your doctor, and possibly with a lawyer.

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3 Responses:

 
Gerald Jones
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said this on
14 Jul 2014 5:38:46 AM PDT
I am one of those people who suffered celiac symptoms as a result of taking Benicar. I suffered from this for eight years not knowing Benicar was the cause. For some reason possibly associated with Benicar I began to suffer dizziness and light-headedness when I stood so my doctor took me off blood pressure medication and all my symptoms disappeared. Since that time I have regained lost weight and show no signs of celiac disease though I still maintain a gluten free diet for fear that I may actually have celiac that put me in the hospital for 15 days one time and again for another 4 after that. Now, though I am not as strict in trying to avoid trace amounts of gluten in my foods and have so far had no problems since coming off Benicar.

 
Daniel Nigh
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said this on
21 Feb 2015 10:30:46 PM PDT
Gerald, did you ever contact this law firm (Levin, Papantonio)?

 
Kathryn Millspaugh
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said this on
15 Jul 2014 1:55:55 PM PDT
I was on Benicar for several years. After my symptoms got bad enough to diagnose, I would get horribly sick within 30 minutes of taking Benicar. I would start feeling bad within 15 to 20 minutes. The vomiting would go on 3 to 3 1/2 hours before it was over. My doctor said she'd heard of that before my case.




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you're lucky you dont catch colds. im the opposite i catch everything very easily and get alot sicker than whoever i caught it from and take much longer to get better.

Even one positive can be diagnostic. This is one: Gliadin deamidated peptide IgG 33.9. If unsure, a biopsy of the small intestine will provide definite confirmation. There is a control test to validate the other ones, but I don't see it there. What is does is validate the others by checking on the overall antibody levels. But it is to detect possible false negatives. A positive is a positive. I think your daughter has joined our club.

My daughter, almost 7 years old, recently had a lot of blood work done, her Dr is out of the office, but another Dr in the practice said everything looked normal. I'm waiting for her Dr to come back and see what she thinks. I'm concerned because there is one abnormal result and I can't find info to tell me if just that one test being abnormal means anything. The reason for the blood work is mainly because of her poor growth, though she does have some other symptoms. IgA 133 mg/dl Reference range 33-200 CRP <2.9 same as reference range Gliadin Deamidated Peptide IgA .4 Reference range <=14.9 Gliadin deamidated peptide IgG 33.9 Reference range <=14.9 TTG IgA .5 Reference range <=14.9 TTG IgG <.8 Reference range <=14.9

Just watch out. I just went to the expo in Schaumburg, IL, and ended up getting glutened. I realized afterward that I ate all these samples thinking they were gluten free, and they weren't. One company was advertising some sugar, and had made some cake, but then I realized.... How do I know if this contains any other ingredients that might have gluten? Did they make it with a blender or utensils that had gluten contamination? Makes me realize the only safe things would be packaged giveaways with gluten free labeling. My fault for not thinking things through. It was just too exciting thinking i could try it all and enjoy without worry.

No fasting required for a celiac blood test unless they were checking your blood glucose levels during the same blood draw.