No popular authors found.
Ads by Google:

Categories

No categories found.


Get Celiac.com's E-Newsletter




Ads by Google:



Follow / Share


  FOLLOW US:
Twitter Facebook Google Plus Pinterest RSS Podcast Email  Get Email Alerts

SHARE:

Popular Articles

No popular articles found.
Celiac.com Sponsors:

Adverse Gluten Reactions Impact Oral Mucosa in Celiac Patients

Celiac.com 07/31/2014 - Although the adverse mucosal reaction in celiac disease occurs mainly in the small intestine, other mucosal surfaces in the gastrointestinal tract and the gut-associated lymphoid tissue are also affected. To better understand the impact, a research team recently set out to examine histopathological findings in the oral mucosa of celiac disease patients.

Photo: Tasmanian Devil--Wikimedia Commons--Wayne McLeanSpecifically, based on the assumption that the oral mucosa could reflect the histopathological intestinal inflammation seen in celiac disease patients, they wanted to determine the pattern of T-cell subsets in the oral mucosa of young adults with celiac disease. The research team included E. Bardellini, F. Amadori, A. Ravelli, M. Salemme, S. Lonardi, V. Villanacci, and A. Majorana.

For their study, they enrolled a group of 37 patients with celiac disease, ranging in age from 20-38 years. Twenty-eight were female, nine male. The team broke the 37 subjects into two groups. The nineteen patients of group A were following a gluten free diet (GFD); two patients for less than one year; 6 patients between 1 and 5 years; 11 patients more than 5 years. The 18 patients (group B) remained untreated.

Meanwhile, fifteen healthy volunteers (age range 18-35 years, 11 females and 4 males served as controls. Because the study involved observing untreated celiac patients, the team sought and received ethical approval for the research from the Ethics Committee.

Ads by Google:

The team took biopsy specimens from normal looking oral mucosa. They conducted immunohistochemical investigation with monoclonal antibodies to CD3, CD4, CD8, and gamma/delta-chains T cell receptor (TCR).

They found T-lymphocytic inflammatory infiltrate significantly higher in group B (p < 0.0001); as compared with group A and with the control group.

Their results confirm that the oral cavity is involved with adverse reactions to celiac disease triggers, and might offer potential for celiac diagnosis.

Source:

Celiac.com welcomes your comments below (registration is NOT required).





Spread The Word







Related Articles



5 Responses:

 
Mark
Rating: ratingfullratingfullratingfullratingfullratingfull Unrated
said this on
04 Aug 2014 9:14:58 AM PDT
I have been on a gf diet for 12 years and can tell when I have been glutened by the outbreak of canker sores the next day.

It seems if a correlation could be made between oral mucosa and the small intestine biopsies, that an oral swab test could be enough for a celiac disease diagnosis

 
R.Borg
Rating: ratingfullratingemptyratingemptyratingemptyratingempty Unrated
said this on
05 Aug 2014 7:37:57 AM PDT
The article did not define and explain oral mucosa nor its symptoms.

 
Jefferson
Rating: ratingfullratingfullratingfullratingfullratingfull Unrated ( Author)
said this on
07 Aug 2014 1:16:41 PM PDT
Are you serious? Oral mucosa is simply the lining of the mouth. Please look things up before commenting.

 
Diana Barnes
Rating: ratingfullratingfullratingfullratingfullratingempty Unrated
said this on
05 Aug 2014 9:20:55 AM PDT
This is great to know, but I have a question. Maybe you can help me or tell me who I can talk to. I have celiac disease and I eat gluten-free but I still get sores in my mouth, WHY?

 
Jefferson
Rating: ratingfullratingfullratingfullratingfullratingfull Unrated ( Author)
said this on
07 Aug 2014 1:19:38 PM PDT
First, I'm not a doctor, so definitely consult one. However, two possibilities are: 1) You may have sensitivities to things besides wheat gluten. 2) You may be getting cross-contamination.




Rate this article and leave a comment:
Rating: * Poor Excellent
Your Name *: Email (private) *:




In Celiac.com's Forum Now:

All Activity
Celiac.com Celiac Disease & Gluten-Free Diet Forum - All Activity

Yes steroids will give a false negative on the DH tests. In addition many doctors will biopsy the lesions when they need to look for antibodies in the intact skin next to active lesions. There are also some times when folks with DH will have negative blood work. Don't know why. After all celiac related testing is done do give the diet a good strict try. At the top of the Coping section is the 'Newbie 101' thread that has a lot of info for you on what you need to do when you are either diagnosed or giving the gluten free diet a try.

Blaze Pizza is great for gluten free, they will change their gloves, a sort of mat under the pizza in the oven, use a separate cutter to slice it, plus it's great pizza! Enjoy!

We are major pizza lovers, so the struggle has been real trying to find good gluten free pizza. We have tried any brand we've come across in many different stores. The best we have found is Sabatasso's from Costco. They might sell it other places as well. We buy our own toppings and make variations other than cheese. Our household has thick and thin crust lovers and this brand manages to satisfy us all.

If your doctor gave you a tis transglutaminase tTG blood test, and your number was atleast 150 (normal is less than 15), by standards of diagnosing celiac in Europe, and now apparently in the USA (according to my pediatric gastroenterologist) , you are confirmed celiac with no need for an upper endoscopy.

If you are able to eat dairy, Against the Grain is hands down the best gluten-free pizza (and I'm from N.Y. coincidentally:-)) http://againstthegraingourmet.com/store-locator Regarding parties, or any social gathering for that matter, I always eat before hand and get a glass of wine or cider when I'm there.