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Gluten-free Diet Promotes Weight Loss, Inflammation Reduction and Prevents Insulin Resistance

Celiac.com 08/18/2014 - A team of researchers recently set out to better understand the effects of gluten-free diets on obesity.

Image of International Diabetes Symbol: Wikimedia Commons--Fred the OysterThe research team included F.L. Soares, R. Matoso de Oliveira, L.G. Teixeira, Z. Menezes, S.S. Pereira, A.C. Alves, N.V. Batista, A.M. de Faria, D.C. Cara, A.V. Ferreira, and J.I. Alvarez-Leite. They are affiliated with the Departamento de Alimentos, Faculdade de Farmácia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais in Belo Horizonte, Brazil.

Specifically, the team wanted to determine whether a gluten-free diet can prevent the expansion of adipose tissue, and its consequences.

For their study, the team fed C57BL/6 mice a high-fat diet containing either 4.5% gluten (Control) or no gluten (GF). They noted body weight and adiposity gains, leukocyte rolling and adhesion, macrophage infiltration and cytokine production in adipose tissue.

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The team measured blood lipid profiles, glycaemia, insulin resistance and adipokines. They also assessed the expression of the PPAR-α and γ, lipoprotein lipase (LPL), hormone sensitive lipase (HSL), carnitine palmitoyl acyltransferase-1 (CPT-1), insulin receptor, GLUT-4 and adipokines in epidydimal fat.

Gluten-free animals showed less body weight and adipose gain, with no changes in food intake or lipid excretion. These results were associated with up-regulation of PPAR-α, LPL, HSL and CPT-1, which are related to lipolysis and fatty acid oxidation.

The team also saw improved glucose regulation, and pro-inflammatory profile-related over-expression of PPAR-γ. Intravital microscopy revealed a lower number of adhered cells in the adipose tissue microvasculature. The over-expression of PPAR-γ is related to the increase of adiponectin and GLUT-4.

The results of this study suggest that gluten-free diets can be helpful in reducing fat gain, inflammation and insulin resistance. They suggest that a gluten-free diet should be tested as a way of preventing the development of obesity and metabolic disorders.

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4 Responses:

 
gina
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said this on
23 Aug 2014 5:39:26 AM PDT
Not enough data.

 
Roberta Steiner
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said this on
25 Aug 2014 11:50:04 AM PDT
I found this article most interesting since in the year before I was diagnosed with celiac disease and went GF I lost 15 pounds with out trying. When I went GF, I was able to regain 10 of those pounds and have happily kept the weight on. My bone mass also increased.

 
Mary Thorpe
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said this on
27 Aug 2014 6:17:03 AM PDT
I was pre-diabetic before going GF. My glucose tolerance test profile became normal over the years on the diet and I always wondered if it was because I'm consuming fewer carbs on the GF diet, or if it was simply because of being GF. This study might give a clue. The article doesn't indicate whether the amount of carbs in the diets was the same. I would hope so but will have to check the article to make sure.

 
Fredburgin
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said this on
07 Dec 2014 11:10:16 PM PDT
This article is really interesting, as they are providing the free diet plans it will surely help the people and also to get relief from this celiac disease.




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