No popular authors found.
Ads by Google:

Categories

No categories found.


Get Celiac.com's E-Newsletter





Ads by Google:


Follow / Share


  FOLLOW US:
Twitter Facebook Google Plus Pinterest RSS Podcast Email  Get Email Alerts
SHARE:

Popular Articles

No popular articles found.
Celiac.com Sponsors:

What’s the Best Way to Diagnose Celiac Disease in Lymphocytic Enteritis Patients?

Celiac.com 09/08/2014 - Currently, physicians trying to diagnose celiac disease in patients with lymphocytic enteritis look for subepithelial deposits of anti-tissue transglutaminase IgA. However, it is known that an increase in CD3+TCRγδ+ coupled with a decrease in CD3- intraepithelial lymphocytes (IEL) is a flow cytometric pattern clearly indicating celiac disease with atrophy.

Photo: CC--Eden Janine and JimTo determine which method yielded better diagnostic results, a research team set out to compare and contrast intestinal intraepithelial lymphocyte cytometric pattern with subepithelial deposits of anti-tissue transglutaminase IgA for diagnosing lymphocytic enteritis due to celiac disease.

The researchers included F. Fernández-Bañares, A. Carrasco, R. García-Puig, M. Rosinach, C. González, M. Alsina, C. Loras, A. Salas, J.M. Viver, M. Esteve.

They are variously affiliated with the Department of Gastroenterology, Hospital Universitari Mutua Terrassa, University of Barcelona, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), the Department of Pediatrics, Hospital Universitari Mutua Terrassa, University of Barcelona, the Department of Pathology, Hospital Universitari Mutua Terrassa, University of Barcelona, CIBERehd, Terrassa, and the Department of Immunology, CATLAB, Viladecavalls, all in Barcelona, Spain.

For their study, the team evaluated 144 women and 61 men, with positive celiac genetics, who underwent duodenal biopsy for celiac disease. Fifty patients showed villous atrophy, and 70 showed lymphocytic enteritis, while 85 showed normal histology. Eight patients with non-celiac atrophy and 15 with lymphocytic enteritis secondary to Helicobacter pylori served as control group.

Ads by Google:

The team used duodenal biopsies to assess both celiac disease, IEL flow cytometric (complete or incomplete), and IF patterns. Sensitivity of IF, and complete and incomplete cytometric patterns for celiac disease diagnosis in patients with positive serology (Marsh 1+3) was 92%, 85% and 97% respectively, but only the complete cytometric pattern showed 100% specificity.

Twelve seropositive and 8 seronegative Marsh 1 patients received a celiac disease diagnosis at the beginning of the study or after gluten free-diet, respectively.

For celiac disease diagnosis in lymphocytic enteritis at baseline, cytometric pattern yielded better diagnostic results than both IF pattern and serology (95% vs 60% vs 60%, p = 0.039).

Analysis of the IEL flow cytometric pattern offers fast, accurate reliable way to spot celiac disease in the initial diagnostic biopsy of patients presenting with lymphocytic enteritis, even for patients with negative blood screens, and seems superior to anti-TG2 intestinal deposits.

These results support the analysis of the IEL flow cytometric pattern as the best way to spot celiac disease at the first diagnostic biopsy of patients presenting with lymphocytic enteritis, even for patients with negative blood screens.

Source:

Celiac.com welcomes your comments below (registration is NOT required).












Related Articles



Comments




Rate this article and leave a comment:
Rating: * Poor Excellent
Your Name *: Email (private) *:




In Celiac.com's Forum Now:


It's unfair to make such a general statement about ER's and hospitals. Unfortunately, I've been to the ER several times and hospitalized three times in the past few years. The staff took me seriously when I told them I had celiac. Popsicles and drinks were checked for gluten, and a good laugh ...

Here is more information about testing family members. https://celiac.org/celiac-disease/understanding-celiac-disease-2/diagnosing-celiac-disease/screening/

Hello, I have been dealing with a mysterious rash for the past ten years that I am slowly beginning to think is DH. It comes and goes, is itchy as all get out and shows up in all the areas that DH appears (elbows, back, torso, knees and base of neck). It comes and goes over the years which...

I'm sorry I don't have much advice for you but I can relate in some ways. I've took generic Zoloft for about 10 years. When I was diagnosed celiac I worried about and researched my medications and am confident that they are safe for me. I have spent many years fighting depression and anxiety and ...

When does it matter if its gluten-free? ( likely is) but she isn't eating it. She isn't 2 and put her fingers and paint brush in her mouth. Are you or your son going to lick the glass? Of course not. Any paint can be be scraped off glass with a razor blade. Some people use dry er...