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Celiac Disease Drug Shows Some Promise, But Offers No Cure

Celiac.com 10/14/2014 - A new drug designed to prevent gluten uptake in the gut is showing some promise for the treatment of celiac disease.

Photo: Drs. Mayo Stamp--Wikimedia CommmonsThe drug, larazotide acetate, significantly reduced symptoms in a large double-blind, placebo-controlled trial. The drug prevents gluten uptake by closing tight junctions in the gastrointestinal (GI) tract.

The drug is intended to supplement, rather than replace, the gluten-free diet that makes up the standard celiac disease treatment. Specifically, the drug is designed to help patients who continue to experience symptoms despite efforts to avoid gluten, and will not allow celiac patients to eat gluten with impunity.

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Some experts are cautioning celiac disease patients against high expectations. Joseph A. Murray, MD, of the Division of Gastroenterology and Hepatology at Mayo Clinic, in Rochester, Minnesota, said that, even if the drug is approved, it would not be a cure for celiac disease, but just another way to control symptoms for those already on a gluten-free diet.

Daniel Leffler, MD, director of research at the Celiac Center of Beth Israel Deaconess Medical Center, in Boston, called the news “exciting.” Dr. Leffler predicted that, if approved, the drug would be a useful addition to standard celiac disease treatment.

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4 Responses:

 
Teresa

said this on
20 Oct 2014 3:07:43 PM PDT
That would be terrific but the side effects could be worse then the actual symptoms.

 
Laura

said this on
21 Oct 2014 4:32:34 PM PDT
What would be the long term effects of such a drug? I would love additional protection from the cross contamination that seems to stalk me, but the last thing I need to deal with are side effects or damage from another drug. Any word on that?

 
Jefferson
Rating: ratingfullratingfullratingfullratingfullratingfull Unrated ( Author)
said this on
23 Oct 2014 5:53:57 PM PDT
This drug is in early trials, so it's impossible to know about long-term effects. So far, the drug seems to be well-tolerated, but only extensive testing and time can answer your question with any certainty.

 
Irv
Rating: ratingfullratingfullratingfullratingfullratingempty Unrated
said this on
23 Oct 2014 8:09:06 AM PDT
Interesting.




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The only symptom I know of that is celiac for certain is dh, which must be diagnosed by a dermatologist.

I have both eoe and celiac and now that I have been gluten free for 18 months, my anemia is gone. It is good to get off the iron supliments because mine may have been the cause of my ulcers. It feels good to recover and heal! I may work my way down to fewer supliments and lots of feel great da...

Your daughter does not have a strong positive. I suspect that the GI might do as RMJ suggested which would be to load her up on gluten for six months and retest. On the other hand, with a diagnosed sibling and a very mild positive, your GI might recommend the endoscopy or run the test again to ...

I was diagnosed with celiac last year on an endoscopy looking for the cause of my anemia. At the time, my GI doc tested m for EoE and it was negative. Fast forward 11 months, I developed sudden heart burn, dysphagia out of the blue. My doc thinks it's EoE. Biopsy was last week and I am still wait...

No, the control test is to verify that she will react to that particular type of test. If she didn't, then certain of the bloods would not be applicable to her. They would be false negatives. As far as tests being weak positives, that's like being a little pregnant. A positive is a positive....