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Will New Celiac Drugs Power Treatment Market to $550 Million by 2023?

Celiac.com 12/16/2014 - Will people with celiac disease spend money on drugs designed to reduce or eliminate adverse reactions to gluten? Drug researchers and investors are betting they will.

Photo: Wikimedia Commons--ChelseaFunNumberOneCurrently, the only proven treatment for celiac disease is a strict gluten-free diet. However, a number of companies are looking to debut drugs for treating celiac disease in the next five years, With that in mind, Abhilok Garg, Ph.D., an immunology analyst with research and consulting firm GlobalData, is projecting sales such drugs in the US and five major European markets Germany, France, Spain, Italy and the UK, to reach approximately $551.1 million by 2023.

The launches of Alba/Teva’s larazotide acetate, Alvine/AbbVie’s latiglutenase, and BioLineRX’s BL-7010 portend a new world of therapies for the estimated 600,000 diagnosed celiac patients in these countries.

With early trials looking promising and no obvious problems on the horizon, analysts expect larazotide acetate to enter the US and 5EU markets in Q1 2018 and Q1 2019, respectively, followed by latiglutenase in Q1 2019 and Q1 2020.

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Latiglutenase is currently being developed as a chronic drug treatment, GlobalData’s interviews with KOLs have indicated that clinical experience with this drug could dictate the way it is prescribed to patients, and that it may in some cases be used as an “on demand” treatment,” says Dr. Garg.

Larazotide acetate works by modulating tight junctions (TJs) in the small bowel epithelium, and has tried to maximize recent research showing that people with celiac disease do have altered intracellular spaces and TJ structures in the lower esophagus.

BL-7010 works by sequestering gliadins, effectively masking them from enzymatic degradation and preventing the formation of immunogenic peptides that trigger an adverse immune reaction when people with celiac disease consume wheat. BL-7010 has cleared early trial hurdles and been found to be safe and well tolerated in both single and repeated-dose administrations.

Does the idea of a reliable treatment for celiac disease appeal to you? Would you try such drugs, or just stick with the gluten-free diet? 

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11 Responses:

 
Matt
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said this on
16 Dec 2014 10:11:19 AM PDT
Yes.

 
henry
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said this on
16 Dec 2014 5:45:08 PM PDT
I'd try the drug, it is next to impossible to avoid all gluten and have a normal, productive lifestyle.

 
Don
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said this on
22 Dec 2014 6:36:20 AM PDT
Yes.

 
Sharon
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said this on
22 Dec 2014 11:54:06 AM PDT
I would absolutely try it, even though I would still eat gluten free. I only trust food I prepare, and even then, mistakes are made. And it would provide a certain level of security when eating out or traveling, even if the food you order is supposedly gluten free.

 
K
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said this on
22 Dec 2014 12:40:29 PM PDT
Yes. celiac can be debilitating and it is so hard to avoid all gluten, short of living in a bubble.

 
Tracy
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said this on
22 Dec 2014 2:33:16 PM PDT
I would definitely try the drug. GF substitutions are notoriously higher in fat and sugar, both no-no's for a diabetic like me.

 
R.Borg
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said this on
22 Dec 2014 2:47:18 PM PDT
I would try the drug.

 
D. Johnson
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said this on
22 Dec 2014 5:41:15 PM PDT
It has been my experience that any medication has side effects and often drugs are released onto the market before being thoroughly tested. My Mother died as a result of a medication that was toxic to her liver. As a result I am super cautious about taking drugs period. I have struggled with the gluten free diet since being diagnosed with celiac disease and although the drugs might be convenient, they may also be debilitating.

 
john j acres
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said this on
27 Dec 2014 2:45:02 PM PDT
Sorry you have the disease--learn to live with it--you cannot eat any healthier than fruit and veggies. Keep away from gluten free products and how about when you get sick your doctor's prescription for antibiotics could become toxic mixed with this new drug.

 
Brad
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said this on
29 Dec 2014 11:33:17 AM PDT
Yes keep the news coming!!!!

 
Lucille Cholerton
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said this on
24 Apr 2015 1:27:50 PM PDT
I would definitely stick with the gluten free diet. In this day and age it is so easy. Much better than resorting to drugs with all their possible side-effects.




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It took me 20 years or more Barry so I wouldn't claim any great insight on this I had a 'eureka' moment, up until then I was walking around with multiple symptoms and not connecting any dots whatsoever. It is very, very difficult to diagnose and that's something that's reflected in so many of the experiences detailed here. A food diary may help in your case. It helped me to connect the gaps between eating and onset. It could help you to track any gluten sources should you go gluten free. It is possible for your reactions to change over time. As to whether its celiac, that's something you could explore with your doctor, stay on gluten if you choose to go that way. best of luck! Matt

I took Zoloft once. Loved it until it triggered microscopic colitis (colonoscopy diagnosed it). Lexapro did the same. However, I have a family member who is fiagnosed celiac and tolerates Celexa well.

Thanks for the update and welcome to the club you never wanted to join! ?

Jmg, I am glad you were able to come to the realisation that the culprit was in fact gluten. For me its not so simple. IBS runs in the family, as do several food intolerances. Its just in the last while that I can finally reach the conclusion that for me its gluten. The fact that it is a delayed effect-several hours after, made it harder. Friday I had some KFC, felt great. Saturday evening felt sleepy, Sunday felt awful and my belly was huge. I think I have gone from mildly sensitive to full blown celiac over the course of five years-if that possible. Thanks for all your help.

I thought I'd take a moment to provide an update, given how much lurking I've done on these forums the last year. It took a long time, but I've since had another gastroenterologist visit, many months of eating tons of bread, and an endoscopy where they took several biopsies. I have to say, the endoscopy was a super quick and efficient experience. During the procedure they let me know that it looked somewhat suspicious, causing them to take many biopsies, and then did comprehensive blood work. About a month later, I received a call telling me that the TTG came back positive a second time, and that the biopsies were a mix of negative (normal) results and some that were positive (showing blunting of the villi). As a result, I've been given a celiac diagnosis. It's been about a month now that I've been eating gluten free. Not sure if I'm really feeling all that different yet. It's a bit twisted to say, but in some way I was hoping for this diagnosis ? thinking how nice it would be to have an explanation, a plan of action, and feeling better. It's certainly no small change to be totally gluten free, but I'm hopeful.