No popular authors found.
Ads by Google:

Categories

No categories found.


Get Celiac.com's E-Newsletter





Ads by Google:


Follow / Share


  FOLLOW US:
Twitter Facebook Google Plus Pinterest RSS Podcast Email  Get Email Alerts
SHARE:

Popular Articles

No popular articles found.
Celiac.com Sponsors:

Point-of-Care Test Helps Spot Undiagnosed Celiac Disease

Celiac.com 01/19/2015 - A team of researchers set out to determine what factors might influence dissemination of a new and validated commercial Point-of-Care Test (POCT) for celiac disease, in the Mediterranean area, when used in settings where it was designed to be administered, especially in countries with poor resources.

Photo: CC--JYL4032The research team included S. Costa, L. Astarita, M. Ben-Hariz, G. Currò, J. Dolinsek, A. Kansu, G. Magazzu, S. Marvaso, D. Micetic-Turku, S. Pellegrino, G. Primavera, P. Rossi, A. Smarrazzo, F. Tucci, C. Arcidiaco, and L. Greco.

For their study, the team relied on family pediatricians in Italy, and nurses and pediatricians in Slovenia and Turkey, to look for celiac disease in 3,559 children aged 1-14 years, 1,480 (ages 14-23 years) and 771 (1-18 years) asymptomatic subjects, respectively. This was done at pediatrician offices, schools and university primary care centers

The team used a new POCT that detects IgA-tissue antitransglutaminase antibodies and IgA deficiency in a finger-tip blood drop. Subjects with positive screens and those suspected of having celiac disease were referred to a Celiac Centre to confirm the diagnosis.

Ads by Google:

The team then estimated POCT Positive Predictive Value (PPV) at tertiary care (with Negative Predictive Value) and in primary care settings, and POCT and celiac disease rates per thousand in primary care.

At tertiary care setting, PPV of the POCT and 95% CI were 89.5 (81.3-94.3) and 90 (56-98.5) with Negative Predictive Value 98.5 (94.2-99.6) and 98.7% (92-99.8) in children and adults, respectively.

In primary care settings of different countries where POCT was performed by a different number of personnel, PPV ranged from 16 to 33%, and the celiac disease rates per thousand ranged from 4.77 to 1.3, while and POCT rates ranged from 31.18 to 2.59, respectively.

This study shows that interpretation of POCT results by different personnel may influence the performance of POC, but that use of POCT is an urgent priority for diagnosing celiac disease among people of countries with limited resources, such as rural populations and school children.

Source:

Celiac.com welcomes your comments below (registration is NOT required).












Related Articles



Comments




Rate this article and leave a comment:
Rating: * Poor Excellent
Your Name *: Email (private) *:




In Celiac.com's Forum Now:


I was working at a anime convention this weekend setting up and running A/V for panel rooms, I know I was handling a bunch of stuff, and around gluten eaters EVERYWHERE, people were walking around eating stuff, and I had to work with equipment others were using while snacking on gluten foods........

PS I am not questioning you here but mango is a odd food, many people might have a allergy to the skin and out side of the mango but have no issues with the inside meat. Others are allergic to the whole fruit. It has to do with a compound found in the skin that is very harsh and triggers allergic...

Hello! I apologize in advance if this is long and a bit detailed, but I'm feeling very anxious, and have so many questions. I'm a 36 year old woman. I've had lots of digestive issues over the last few years. Nothing overly bad, but definitely unpredictable, comes and goes. I deal with anxiet...

Yes, we like peanut butter in the blender with frozen bananas and a liquid (juice, coconut water, almond milk...). You can add berries or even ginger and turmeric.

Yes, because each persons immune system is different there's a lot of uncertainty around tests. I think I'd be gluten-free for a couple of weeks when I first tested and my doctor thought it wouldn't make a difference. I often wonder if I'd have got a test just before going gluten-free, when I fel...