No popular authors found.
Ads by Google:

Categories

No categories found.


Get Celiac.com's E-Newsletter





Ads by Google:


Follow / Share


  FOLLOW US:
Twitter Facebook Google Plus Pinterest RSS Podcast Email  Get Email Alerts
SHARE:

Popular Articles

No popular articles found.
Celiac.com Sponsors:

Can Understanding Molecular Similarities Help Us Cure Autoimmune Diseases?

Celiac.com 03/25/2015 - In what may prove to be a remarkable step in understanding human diseases, a team of scientists affiliated with Northeastern University has found a way to connect diseases based on their shared molecular interactions.

Photo: Wikimedia Commons--JPM32A paper by the Northeastern team appears in the journal Science. The paper details their creation of a mathematical tool to analyze the map of the molecular interactions within cells, called the human interactome, and the discovery that over-lapping disease modules, or "neighborhoods" of disease-associated proteins, can give rise to some very unexpected relationships between diseases.

Increasing amounts of research, says Albert-László Barabási, are making it very clear that "human diseases can be interpreted only in the context of the intricate molecular network between the cell’s components."

Barabási is Robert Gray Dodge Professor of Network Science and University Distinguished Professor and director of Northeastern’s Center for Complex Network Research. The Northeastern researchers are based in the Center for Complex Network Research. The team comprises Barabási, Menche, postdoctoral researcher Maskim Kitsak, research assistant professor Amitabh Sharma, and graduate physics student Susan Dina Ghiassian, PhD’15.

For their study, the Northeastern team analyzed 299 diseases that had at least 20 associated genes. They found that 226 of the diseases had their own specific "neighborhood" within the interactome. They noticed that diseases within the same neighborhood had more in common in terms of molecular functions or symptoms, while diseases that were far away from each other within the interactome had very little in common in terms of molecular functions or symptoms.

Ads by Google:

Among their findings, they noted that asthma, and celiac disease are localized in overlapping neighborhoods, which suggests shared molecular roots, even though they have very different pathobiologies.

This is the first study to show that the available network maps offer enough coverage and accuracy to provide valuable information about the molecular origins of disease-disease relationships, says Jörg Menche, a postodoctoral researcher and one of the authors on the paper.

This is a very interesting and potentially promising discovery that may pave the way for a much deeper understanding of relationships between celiac and numerous other diseases.

Stay tuned for more news.

Source:

Celiac.com welcomes your comments below (registration is NOT required).












Related Articles



1 Response:

 
Janice Lamb
Rating: ratingfullratingfullratingfullratingfullratingfull Unrated
said this on
30 Mar 2015 6:34:42 AM PDT
This sounds very, very interesting!!




Rate this article and leave a comment:
Rating: * Poor Excellent
Your Name *: Email (private) *:




In Celiac.com's Forum Now:


Hey guys, I will try and keep this as short and concise as I can. About a year ago, I had a very long day at work and ate a lot of chicken wings and a very poor diet. The next week, I felt terrible. I head headaches, GI issues, fatigue and some muscle aches and nasal congestion. I thought it...

Hi Jmg - and anyone who is familiary with ranitidine (Zantac) Firstly, Jmg, I hope you don't mind my quoting your old post from last month to get your attention, but I wanted to speak to a fellow Brit as I'd value some advice from someone who knows how the NHS works. (I love the NHS by the w...

Thanks Marry. Your story is very similar indeed. I totally agree that the migraines are the worst symptom - the pain was terrible and there were times when I was almost convinced that I had a brain tumor. I'm glad you replied to my post because at least I can see that it's not all just in my...

That sucks I know you'd been looking forward to it. Well until you know you have try and forget about it and maybe you got lucky. You're due some good luck I think!

Make some concise notes in bullet point form to make sure you cover what you need to. You have a strong case for further investigation so if your doctor is reluctant don't be afraid to be assertive in looking for answers.