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Can Better Biopsy Practices Improve Celiac Diagnosis in Children?
Celiac.com 03/27/2015 - Researchers don't have any solid idea about how common cases of seronegative celiac disease might be, but many feel strongly that rates of seronegative celiac disease are underestimated in children, and may result in misdiagnosis of celiac cases.
One team of researchers wondered if an emphasis on "serology-led" diagnosis might be contributing to a low rate of celiac disease diagnosed in children from the United States. That research team included Deborah L. Preston and Yoram Elitsur, and they recently set out to investigate the rate of celiac disease after upper endoscopy (EGD) with no prior positive celiac serology compared with the rate of celiac disease followed by positive serology.
The team conducted a retrospective review of that charts of all of the first diagnostic EGDs in children (2009–2013). They split the patients with confirmed celiac disease into 4 groups: group A, positive EGD/positive serology (histology-led diagnosis); group B, positive serology/positive histology (serology-led diagnosis); group C, positive histology followed by negative serology (control 1); and group D, positive serology followed by negative histology (control 2).
The team reviewed a total of 761 upper endoscopic charts. They confirmed 15 children with celiac disease, for a rate of 1.97%. Group A and group B had similar demographic data or clinical symptoms, and similar rates of celiac disease between histology-led celiac diagnosis (group A) and serology-led celiac diagnosis (group B) (1.18% vs 0.79%, P = 0.273).
This study showed that endoscopy-led diagnosis and serology-led diagnosis found celiac disease at similar rates.
- Journal of Pediatric Gastroenterology & Nutrition: March 2015 - Volume 60 - Issue 3 - p 357–359. doi: 10.1097/MPG.0000000000000602
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Mortality Rates for Celiacs with Persistent Villous Atrophy Similar to Those with Healthy Guts
Villous atrophy (VA) in the small intestine is one of the prime features of celiac disease, and has been associated with increased mortality, but it is unknown if mortality is influenced by mucosal recovery.... [READ MORE]
Enzyme Reaction Promises Better Understanding of Celiac Disease
According to the latest findings by a Norwegian research team, the inner workings of a particular enzymatic reaction is helping scientists figure out how celiac disease develops.... [READ MORE]
Dietary Supplementation with Probiotics may be Beneficial in Celiac Disease
A life-long gluten-free diet is currently the only treatment for celiac disease.... [READ MORE]
Natural Killer Cell Activity in Celiac Disease - Czech Republic
Castany M, Nguyen H, Pospisil
M, Fric P, Tlaskalova-Hogenova H
Natural killer cell activity in coeliac disease: effect
of in vitro treatment on effector lymphocytes and/or target
lymphoblastoid, myeloid and epithelial cell lines with gliadin
Folia Microbiol, 1995 (Praha) 40; 6: 615-620.... [READ MORE]
Jefferson Adams is a freelance writer living in San Francisco. His poems, essays and photographs have appeared in Antioch Review, Blue Mesa Review, CALIBAN, Hayden's Ferry Review, Huffington Post, the Mississippi Review, and Slate among others.
He is a member of both the National Writers Union, the International Federation of Journalists, and covers San Francisco Health News for Examiner.com.View all articles by Jefferson Adams