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Dr. Falk Pharma and Zedira Test New Celiac Disease Drug

Celiac.com 04/24/2015 - Dr. Falk Pharma and Zedira recently announced the start of phase I clinical trials for the drug candidate ZED1227, a direct acting inhibitor of tissue transglutaminase.

Image: Dr. Falk Co.The small molecule targets the dysregulated transglutaminase within the small intestine in order to dampen the immune response to gluten which drives the disease process. This approach will offer patients additional safety when applied in support of a ‘mostly’ gluten-free diet thereby improving the quality-of-life of millions of people.

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In 2011, Dr. Falk Pharma licensed the rights for ZED1227 in Europe and took charge of pre-clinical and clinical development of the new drug. The license agreement secured Zedira an upfront payment and further milestone payments as well as royalties. The rights outside Europe are jointly owned by the partners.

The project receives additional support through a grant from the German Ministry for Education and Research within the Cluster of Excellence program “Ci3-Cluster for Individualized Immune Intervention."

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8 Responses:

 
dappy
Rating: ratingfullratingfullratingemptyratingemptyratingempty Unrated
said this on
27 Apr 2015 6:42:26 AM PDT
?? This approach will offer patients additional safety when applied in support of a ‘mostly’ gluten-free diet thereby improving the quality-of-life of millions of people.
What does this really mean, and will it be of any consequence?

 
Jefferson Adams
Rating: ratingfullratingfullratingfullratingfullratingfull Unrated ( Author)
said this on
27 Apr 2015 10:03:00 AM PDT
This drug, and several others under development, are designed to offer people with celiac disease additional protection against accidental gluten contamination/ingestion.

 
Chloe
Rating: ratingfullratingfullratingfullratingemptyratingempty Unrated
said this on
02 May 2015 5:16:43 AM PDT
It means that if this is released it will no doubt be your highest insurance copay if covered at all for a problem that is easily treated without medication. If covered it will require prior authorization by insurance and in addition to buying expensive gluten free products you can add a large monthly copay for a pill.

 
Jackay
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said this on
27 Apr 2015 11:55:56 AM PDT
It is hard to avoid gluten cross-contamination so this could address the 'mostly' gluten free diet.

I am wondering if this would help those that have not been diagnosed as celiac and may be just gluten intolerant. Also, would one have to be diagnosed as celiac to get this prescribed?

 
Edith
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said this on
27 Apr 2015 1:06:27 PM PDT
Encouraging to hear that drugs are being tested to protect against accidental gluten ingestion -- the biggest threat. I don't think anyone expects to be able to order a cinnamon roll or pizza without consequences ... but to eat out with the usual gluten-free precautions and not worry about a careless cross contamination incident would be life changing.

 
Irv Leibowitz
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said this on
28 Apr 2015 6:15:39 AM PDT
Good news.

 
Chloe
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said this on
02 May 2015 5:07:04 AM PDT
Crazy. Here is a problem easily treated without medication. Now lets have a drug, like all of the others that will of course be your highest copay if released and I have no doubt will require priorauthorization. Typical to just fix everything with a pill.

 
Ida
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said this on
07 Jul 2015 1:20:18 PM PDT
Do you have celiac, if not, you have no idea what being gluten free cost to people who have this condition. To only eat under the purest kitchen possible. To know positively you can safely eat out with out becoming ill all over again... like starting over.. Yes, my husband will take a pill just as he does for his blood pressure and just like he does for his cholesterol!




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