No popular authors found.
Ads by Google:

Categories

No categories found.


Get Celiac.com's E-Newsletter





Ads by Google:


Follow / Share


  FOLLOW US:
Twitter Facebook Google Plus Pinterest RSS Podcast Email  Get Email Alerts
SHARE:

Popular Articles

No popular articles found.
Celiac.com Sponsors:

Celiac Disease Not a Big Factor in Gastro-esophageal Reflux Disease

Celiac.com 05/21/2015 - Some studies have indicated higher rates of reflux in patients with celiac disease, but there hasn't really been any clear data on the risk for celiac disease in patients presenting with reflux.

Photo: CC--Mike LichtA team of researchers recently set out to determine rates of celiac disease in patients with GORD, and to better understand the nature of reflux symptoms in newly diagnosed celiac disease patients.

The research team included P.D. Mooney, K.E. Evans, M. Kurien, A.D. Hopper, and D.S. Sanders. They are affiliated with the Regional GI and Liver Unit, Royal Hallamshire Hospital, Sheffield, South Yorks, UK.

The team divided the patients into groups as follows:

Group A included 3368 patients who had undergone routine duodenal biopsy, and prospectively recruited between 2004 and 2014. Researchers compared these results with those of a screening control group.

Group B included 32 patients with newly diagnosed celiac disease who had undergone esophageal manometry and 24-h pH studies, prospectively recruited.

The results showed the following:

Ads by Google:

Of the 3368 patients in Group A who received routine duodenal biopsy, 850 (25.2%) presented with GORD.

Rates of celiac disease among GORD patients was just 1.3% (0.7-2.4%), about the same as in the general population (P=0.53).

Routine duodenal biopsy at endoscopy showed that reflux was negatively associated with celiac disease, with an adjusted odds ratio of 0.12 (0.07-0.23), P<0.0001.

In group B, about one third of patients complained of reflux. Manometry showed that just under 10% had a hypotensive lower esophageal sphincter, and 40.6% had esophageal motor abnormalities, with 25% showing significant hypocontraction. Also, pH study did show that one in three did in fact suffer reflux episodes.

The main takeaway from this study is that GORD patients have undiagnosed celiac disease at about the same rate as the general population, and so routine duodenal biopsy cannot be recommended for patients with GORD.

Interestingly, pH/manometry studies showed a fairly high percentage of newly diagnosed celiac patients with reflux and/or esophageal dysmotility; which might explain the high prevalence of reflux symptoms in celiac disease.


Source:

Celiac.com welcomes your comments below (registration is NOT required).












Related Articles



2 Responses:

 
Deb
Rating: ratingfullratingfullratingfullratingemptyratingempty Unrated
said this on
26 May 2015 12:22:24 PM PDT
My celiac was found in the jejunum, I had horrible gastric reflux prior to diagnosis. Perhaps duodonum biopsy was not looking good enough.

 
Jefferson
Rating: ratingfullratingfullratingfullratingfullratingfull Unrated ( Author)
said this on
10 Jun 2015 12:46:55 PM PDT
Gastric reflux is fairly common in people with celiac disease. However, celiac disease is not unusually common in people with gastric reflux disease (GERD). I hope that helps.




Rate this article and leave a comment:
Rating: * Poor Excellent
Your Name *: Email (private) *:




In Celiac.com's Forum Now:


Yeah I tend to have Mr. Hyde come out with gluten exposure. Honestly he was not present with my last few minor issues....anyway. Plenty of fluids, bone broths if she can do them. whole food soups. Avoid processed foods, have more whole foods and greens. Green and herbal teas can help. NOTE there ...

My daughter (6) was recently glutened by a friend of the family. She gave her a drink that didn't have gluten in it but was made at a factory that has gluten contamination. She recently just started a brand new school because we hadn't diagnosed her allergies yet and she has severe behavior pr...

I'm so sorry. Nursing school is rigorous enough on top of all this stress. And, kudos to you for cooking regularly even in school. I've been through a lot of school and I never managed that. I can see how it feels hopeless to try and change your roommate's behavior - almost like an insurmounta...

"Any Coeliac will tell you the most awkward time of the day for them is lunch" Ya just can't make stuff like this up. Lunchtime is awkward?

Shouldn't they be studying why celiacs who have been gluten-free for a year are still seropositive and having moderate to severe symptoms? It sounded like the pill was suppposed to be taken with meals that might have cc ? So why would they do a study where it's given with gluten-free meals?...