No popular authors found.
Ads by Google:

Categories

No categories found.


Get Celiac.com's E-Newsletter




Ads by Google:


Questions? Join Our Forum:
~1 Million Posts
& Over 66,000 Members!



SHARE THIS PAGE:
Celiac.com Sponsors:

Neuropathy Risk More than Double for Celiac Disease Patients

Celiac.com 06/01/2015 - Earlier research on celiac disease and neuropathy has been hampered by the use of inpatient data, low study power, and lack of information on neuropathic characteristics.

Image: CC--Margherita J. L. LisoniA team of researchers recently set out to accurately assess both relative and absolute risk of developing neuropathy in a nationwide population-based sample of patients with biopsy-verified celiac disease. The research team included Sujata P. Thawani, MD, MPH; Thomas H. Brannagan III, MD; Benjamin Lebwohl, MD, MS; Peter H. R. Green, MD; and Jonas F. Ludvigsson, MD, PhD.

They are variously affiliated with the Peripheral Neuropathy Center at the Neurological Institute of Columbia University College of Physicians and Surgeons, the Celiac Disease Center in the Department of Medicine at Columbia University College of Physicians and Surgeons in New York, New York, with the Department of Medical Epidemiology and Biostatistics at the Karolinska Institutet in Stockholm, Sweden, and with the Department of Pediatrics, Örebro University Hospital, Örebro University, Örebro, Sweden.

For their study, the team collected data on small-intestinal biopsies conducted at Sweden’s 28 pathology departments from 1969 to 2008. They compared the risk of neuropathy in a total of 28 ,232 celiac disease patients, all with villous atrophy, Marsh 3, against results from 139, 473 age- and sex-matched non-celiac control subjects.

Ads by Google:

They used Cox proportional hazards regression to estimate hazard ratios (HRs), and 95% confidence intervals (CIs), for neuropathy as defined by relevant International Classification of Diseases codes in the Swedish National Patient Register; including both inpatient and outpatient data.

They found that patients with biopsy-verified celiac disease faced a 2.5 times higher risk of developing neuropathy (95% CI, 2.1-3.0; P < .001). Celiac patients also had an increased risk of developing chronic inflammatory demyelinating neuropathy (2.8; 1.6-5.1; P = .001), autonomic neuropathy (4.2; 1.4-12.3; P = .009), and mononeuritis multiplex (7.6; 1.8-32.4; P = .006).

However, the team found no association between celiac disease and acute inflammatory demyelinating polyneuropathy (0.8; 0.3-2.1; P = .68).

The team found a significantly increased risk of neuropathy in patients with celiac disease, and they are recommending that doctors screen patients with neuropathy for celiac disease.

Source:

Celiac.com welcomes your comments below (registration is NOT required).












Related Articles



Comments




Rate this article and leave a comment:
Rating: * Poor Excellent
Your Name *: Email (private) *:




In Celiac.com's Forum Now:


I can not help you with the Candida issues (except to advise reducing sugar from your diet and talk to your doctor about antifungals). I can tell you that my folate and B vitamin levels were off the chart. No, I did not have cancer, which is what you will find if you google). Yes, I have auto...

It could be celiac disease related or not. The fact is her antibodies are still elevated. They have come down dramatically (great job!) and she has had some intestinal healing, but she is not completely healed. She probably needs more time. She is under a lot of stress which is known to affe...

Done and wish you luck. I moved to a full on keto/paleo diet after also. This might be why it does not come back, once you get rid of it probiotics help keep it in check as they eat the yeast.

Ennis_TX Can you please delete the post that you just created as I had my name attached to it and have edited that out of my original post? I unfortunately cannot edit your post. Also, thanks for the candida diet suggestions. I've looked at the link and have gone that route before.

Take it your referring to soy sauce being made with wheat. Yes since it is used almost everywhere eating at a chinese restaurant is almost impossible to avoid CC. the Grill and and most cooked food is off limits. In High end places the sushi is fixed separately and not with soy sauce in the prep....