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Do Perinatal Risk Factors Influence Development of Celiac Disease in Children?

Celiac.com 06/12/2015 - Some researchers have suspected that certain prenatal and perinatal factors might affect risk for development of celiac disease, but there is very little data. With this in mind, a team of researchers set out to determine if any prenatal and perinatal factors might affect risk for development of celiac disease in children.

Photo: CC--BeshefTheir team assessed the association of fetal growth, birth weight, and mode of delivery with development of celiac disease within the Norwegian Mother and Child (MoBa) Cohort Study. The research team included Louise Emilsson, Maria Christine Magnus, and Ketil Størdal. They are variously affiliated with the Primary Care Research Unit, Vårdcentralen Värmlands Nysäter, County Council of Värmland, Sweden, the Department of Health Management and Health Economy, Institute of Health and Society, University of Oslo, Oslo, Norway, the Division of Epidemiology, Norwegian Institute of Public Health, Oslo, Norway, and the Paediatric Department, Ostfold Hospital Trust, Fredrikstad, Norway.

To make their determination, the team used the MoBa cohort, which contains pregnancy information on 95,200 women and data on their 114,500 children. The information was collected in Norway from 1999 through 2008; it is linked to the Norwegian Medical Birth Registry. The team used the National Patient Registry and women’s responses to MoBa questionnaires to identify women and children with celiac disease.

The team calculated odds ratios (ORs) for celiac disease by using a multivariable logistic regression model, adjusting for maternal celiac disease, sex of children, and children’s age (model 1). In model 2, they adjusted for age of gluten introduction and duration of breastfeeding.

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The team identified 650 children with celiac disease and 107,828 controls in the MoBa database. They found no connection between birth weight or height with celiac disease, including for children who were born small for gestational age.

They found no celiac disease connection based on mode of delivery (cesarean section, model 1: OR, 0.84; 95% confidence interval [CI], 0.65–1.09, and model 2: OR, 0.83; 95% CI, 0.63–1.09). They did find that maternal celiac disease, adjusted for age and sex of the children and type 1 diabetes were associated with development of celiac disease in children, whereas maternal type 2 diabetes and gestational diabetes were not.

Their analysis of the Norwegian MoBa cohort shows that development of celiac disease in children is significantly associated with sex of the child, maternal celiac disease, and type 1 diabetes, but not with gestational development.


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Yes but...

I didn't read that far. Yikes... A hefty dose of perspective in that one. For anyone reading this is the post:

Hi! I'm new to the Celiac world. I have been gluten free for around seven months, but still seem to get glutened on a regular basis. I have been sick since January '16 and think that is when it triggered, but I didn't realize until October what it was. By that time I was pregnant with my little boy who is due in June. I also have an almost 4 year old daughter. I am really torn and wondering if I need to really be tested? I have very strong suspicions that I am a true celiac because my aunt has been diagnosed. Part of me says it doesn't matter, just live gluten free and assume you are, but the other part says I need to get tested so I know if my kids are at risk. So far my daughter is fine. She was grain free until after her first birthday, I plan on doing the same with my son. But I also don't want them to suffer the way I have. What would you do? The reason I don't want to get tested is I don't want to start eating it again and feel terrible while I have little kids, last year was so hard and I just want to get strong again. I also plan to bf for a few years and don't necessarily think it's a good idea to eat gluten while bf right? Thank you!

Welcome too! Sorry to hear you're suffering now. If you can nail the diet you should improve. You should also think about vitamin supplements. There's a good chance that you're suffering from one or more deficiencies as a result of the affects of celiac on your intestine's capacity to draw nutrients from your food. A good multi vitamin is a must, just make sure its gluten free and see if your doctor can refer you to a dietician as Lochella's has.

Oh I had heard his name and read some stuff about him but hadn't come across this video! Thanks!!