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Effector and Suppressor T cells in Celiac Disease

Celiac.com 08/17/2015 - In an interesting update, researcher Giuseppe Mazzarella, of the Immuno-Morphology Lab at the Institute of Food Sciences of the National Council Research in Avellino, Italy recently set out to examine the role of effector and suppressor T cells in celiac.

Image: Wikimedia Commons: NIAID/NIHCeliac disease is a T-cell-mediated immune disorder in which gliadin-derived peptides activate lamina propria effector CD4+ T cells.

This activation triggers the release of cytokines, compatible with a Th1-like pattern, which play a crucial role in the development of celiac disease, and which control many aspects of the inflammatory immune response.

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Previous studies revealed that a novel subset of effector T cells, marked by expression of high levels of IL-17A, termed Th17 cells, plays a key role in celiac disease.

Although these effector T cell subsets produce pro-inflammatory cytokines, which cause significant tissue damage in celiac sufferers, recent studies have suggested the existence of additional CD4(+) T cell subsets with suppressor functions.

These subsets include type 1 regulatory T cells and CD25(+)CD4(+) regulatory T cells, expressing the master transcription factor Foxp3, which have important implications for the development and progression of celiac disease.

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1 Response:

 
Coloradosue
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27 Aug 2015 5:55:10 PM PDT
In plain English, would someone please explain what this information says. The majority of people who read this will no doubt ask " Is this a good thing?". How about next time another article like this comes around be aware that a lot of us who have CD are always interested in new information that may someday make our lives tolerable. Genetically, there is no cure. But, any new drug, vaccine, pill, etc., that may help people in the future is always worth reading about.
BTW, why does the medical profession not recommend a CD test to men and women for the genetic markers of CD before becoming pregnant????? Especially since Celiac Disease is more previlant? Had I known, I would not have had a child who also has Celiac Disease and passed it on to her two sons, my grandsons. The only warning she had was after I had been diagnosed in my early 50's. Mine was switched "on" by the double pneumonia. Hers was turned "on" by a kidney infection. One son had his turned "on" from a bacterial infection. Her youngest is showing signs as well. Just Asking!!!!!




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