No popular authors found.


Get Celiac.com's E-Newsletter

Categories

No categories found.







Ads by Google:


Questions? Join Our Forum:
~1 Million Posts
& Over 66,000 Members!



SHARE THIS PAGE:
Celiac.com Sponsors:

Effector and Suppressor T cells in Celiac Disease

Celiac.com 08/17/2015 - In an interesting update, researcher Giuseppe Mazzarella, of the Immuno-Morphology Lab at the Institute of Food Sciences of the National Council Research in Avellino, Italy recently set out to examine the role of effector and suppressor T cells in celiac.

Image: Wikimedia Commons: NIAID/NIHCeliac disease is a T-cell-mediated immune disorder in which gliadin-derived peptides activate lamina propria effector CD4+ T cells.

This activation triggers the release of cytokines, compatible with a Th1-like pattern, which play a crucial role in the development of celiac disease, and which control many aspects of the inflammatory immune response.

Ads by Google:

Previous studies revealed that a novel subset of effector T cells, marked by expression of high levels of IL-17A, termed Th17 cells, plays a key role in celiac disease.

Although these effector T cell subsets produce pro-inflammatory cytokines, which cause significant tissue damage in celiac sufferers, recent studies have suggested the existence of additional CD4(+) T cell subsets with suppressor functions.

These subsets include type 1 regulatory T cells and CD25(+)CD4(+) regulatory T cells, expressing the master transcription factor Foxp3, which have important implications for the development and progression of celiac disease.

Source:

Celiac.com welcomes your comments below (registration is NOT required).












Related Articles



1 Response:

 
Coloradosue
Rating: ratingfullratingfullratingfullratingfullratingfull Unrated
said this on
27 Aug 2015 5:55:10 PM PST
In plain English, would someone please explain what this information says. The majority of people who read this will no doubt ask " Is this a good thing?". How about next time another article like this comes around be aware that a lot of us who have CD are always interested in new information that may someday make our lives tolerable. Genetically, there is no cure. But, any new drug, vaccine, pill, etc., that may help people in the future is always worth reading about.
BTW, why does the medical profession not recommend a CD test to men and women for the genetic markers of CD before becoming pregnant????? Especially since Celiac Disease is more previlant? Had I known, I would not have had a child who also has Celiac Disease and passed it on to her two sons, my grandsons. The only warning she had was after I had been diagnosed in my early 50's. Mine was switched "on" by the double pneumonia. Hers was turned "on" by a kidney infection. One son had his turned "on" from a bacterial infection. Her youngest is showing signs as well. Just Asking!!!!!




Rate this article and leave a comment:
Rating: * Poor Excellent
Your Name *: Email (private) *:




In Celiac.com's Forum Now:


In Austin, Wildwood Bakehouse and Wilder Wood Restaurant are totally gluten free. I had the chicken fried steak and gravy and onion rings!!! Awesome!!!

If you yourself have Celiac's disease, you probably shouldn't give gluten-free sandwiches to the homeless, because they're disgusting. Your male neighbor doesn't need tampons. That sort of reasoning should be applied. But you must always remember that the Gospel requires you to treat other people...

Hi there I have this exact same thing.. however I don?t have celiac that I know of.. I found this when google searching for what the heck is wrong with my face. I was wondering if you ever found out.. or if it just went away. Thanks

I have read the newbie 101 and have been careful about reading labels. I'm the only one that's gluten free in my household, so they could be contaminating me. I was eating gluten for 6 weeks after my blood test because it took that long to get an official diagnosis and my GP told me to still be e...

Hi and Welcome to the Forum. I am glad that you are here! As with a lot of things in life, try not to compare yourself to other people. You are trying to be the best version of yourself - not Jill, Annie, or Maya. People make a lot of foolish decisions in the world and it does not mean tha...