No popular authors found.
Ads by Google:

Categories

No categories found.


Get Celiac.com's E-Newsletter





Ads by Google:


Follow / Share


  FOLLOW US:
Twitter Facebook Google Plus Pinterest RSS Podcast Email  Get Email Alerts
SHARE:

Popular Articles

No popular articles found.
Celiac.com Sponsors:

Patients with Active Celiac Disease At Slightly Higher Risk for Eosinophilic Esophagitis

Celiac.com 09/09/2015 - Some researchers and clinicians suspect a connection between eosinophilic esophagitis (EoE) and celiac disease, but prior studies have shown conflicting results

Image: Wikimedia Commons--Ed Uthman, MD.A team of researchers recently set out to determine the relationship between EoE and celiac disease among patients with concomitant esophageal and duodenal biopsies. The research team included Elizabeth T. Jensena, Swathi Eluria, Benjamin Lebwohl, Robert M. Gentab, and Evan S. Dellon.

For their cross-sectional study, they team used data covering the period from January 2009 through June 2012 from a U.S. national pathology database.

They defined esophageal eosinophilia as the presence of ≥15 eosinophils per high-power field. The crude and age and sex adjusted odds of esophageal eosinophilia for patients with active celiac disease were compared with those without celiac disease.

Sensitivity analyses were performed by using more stringent case definitions and by estimating the associations between celiac disease and reflux esophagitis and celiac disease and Barrett’s esophagus.

Out of 292,621 patients in the source population, the team looked at data from 88,517 patients with both esophageal and duodenal biopsies. Four thousand one hundred one (4.6%) met criteria for EoE, and 1203 (1.4%) met criteria for celiac disease. Patients with celiac disease had 26% higher odds of EoE than patients without celiac disease (adjusted odds ratio, 1.26; 95% confidence interval [CI], 0.98–1.60).

Ads by Google:

The strength of the connection varied according to EoE case definition, but all definitions showed a weak positive association between the two conditions.

Interestingly, this study showed no connection between celiac disease and reflux esophagitis (adjusted odds ratio 0.95; 95% CI, 0.85–1.07) or between celiac disease and Barrett’s esophagus (adjusted odds ratio 0.89; 95% CI, 0.69–1.14).

Overall, this study showed only a weak increase in EoE in patients with celiac disease. The connection strengthened in direct relation to the strength of definitions of EoE, and was not seen with other esophageal conditions.

Doctors should consider concomitant EoE in patients with celiac disease where clinical indications support it.

Disclosures: Dellon reports receiving research funds from Meritage Pharma, consulting for Aptalis, Novartis, Receptos and Regeneron, and receiving an educational grant from Diagnovus.

Source:

Celiac.com welcomes your comments below (registration is NOT required).












Related Articles



Comments




Rate this article and leave a comment:
Rating: * Poor Excellent
Your Name *: Email (private) *:




In Celiac.com's Forum Now:


Welcome! How old is your son? Has he had follow-up celiac testing to help determine if he might be getting trace gluten contamination? Have other autoimmune disorders been ruled out (inflammatory bowel Disease (IBD: Crohn's or Ulcerative Colitis)? He could develop more than one autoim...

Looks the same unless I make the browser window thinner by about 20%. If I make it 20% thinner the poster identities and new topic button show up.

Hello, my son is a diagnosed celiac, for the past 10 years. It seems that he is extra susceptible to various enteroviruses, or "stomach bugs". He is frequently ill with the standard nausea, vomiting, headache sometimes diarrhea or fever. I have always thought this was linked to the celiac; that...

My daughter's burping what terrible! We saw a pediatric GI at the University of Chicago. Insurance covered the breath test. We tried flagyl first but my daughter had a bad reaction to it and so the doctor ordered Xifaxin. She had to submit additional information to get it covered, but ultimately ...

I had the same problem long before I knew I had celiac. Restasis did not help me at all. I was referred to an eye specialist, and he was very helpful. He said to continue with Restasis, but I told him it was a waste of time. He told me that it doesn't work for everyone. He also gave me a Bru...