No popular authors found.
Ads by Google:

Categories

No categories found.


Get Celiac.com's E-Newsletter





Ads by Google:


Follow / Share


  FOLLOW US:
Twitter Facebook Google Plus Pinterest RSS Podcast Email  Get Email Alerts
SHARE:

Popular Articles

No popular articles found.
Celiac.com Sponsors:

Cause of Celiac Disease Identified – Stanford Team Begins Quest for Cure

Celiac.com 09/30/2002 - As reported in the September 27, 2002 issue of Science, Dr. Chaitan Khosla, professor of chemistry and chemical engineering at Stanford University, and colleagues have identified the specific protein fragment that causes intestinal damage when people with celiac disease eat grains such as wheat, rye, and barley. Graduate student Lu Shan from the Stanford team was able to identify the specific protein fragment in gluten that triggers the damaging attack by T-cells in individuals with the disease. The key fragment is made up of 33 amino acids that are normally broken down in the digestive systems of healthy individuals, but not in those with celiac disease.

In addition to this discovery, the Stanford team is also beginning their search for a celiac disease cure. To that end they have developed an enzyme treatment that renders the newly discovered harmful amino acid sequence in gluten harmless in the guts of test animals, and hope that it will do the same in humans. Several more years of research must be done in order to determine if it will be effective in humans. Dr. Khosla warns against undue optimism regarding the preliminary results of their new enzyme therapy, and stresses that it is too early to raise the hopes of those with celiac disease.

To fund the teams future research efforts Dr. Khosla and colleagues have established the Celiac Sprue Research Foundation, whose goal is finding a cure for the disease. The foundation must raise two million dollars by 2003 in order to begin serious scientific research to that end. Anyone interested in making a tax deductible contribution should go to their Web site: www.celiacsprue.org.

I personally believe that the work of the Celiac Sprue Research Foundation represents our best shot at a cure for celiac disease.
- Scott Adams, Celiac.com.

Ads by Google:


Medline Abstract:

Intestinal Digestive Resistance of Immunodominant Gliadin Peptides.

Am J Physiol Gastrointest Liver Physiol 2002 Oct;283(4):G996-G1003
Hausch F, Shan L, Santiago NA, Gray GM, Khosla C.
Department of Chemical Engineering, Stanford University, Stanford, California 94305-5025.

Two recently identified immunodominant epitopes from alpha-gliadin account for most of the stimulatory activity of dietary gluten on intestinal and peripheral T lymphocytes in patients with celiac sprue. The proteolytic kinetics of peptides containing these epitopes were analyzed in vitro using soluble proteases from bovine and porcine pancreas and brush-border membrane vesicles from adult rat intestine. We showed that these proline-glutamine-rich epitopes are exceptionally resistant to enzymatic processing. Moreover, as estimated from the residual peptide structure and confirmed by exogeneous peptidase supplementation, dipeptidyl peptidase IV and dipeptidyl carboxypeptidase I were identified as the rate-limiting enzymes in the digestive breakdown of these peptides. A similar conclusion also emerged from analogous studies with brush-border membrane from a human intestinal biopsy. Supplementation of rat brush-border membrane with trace quantities of a bacterial prolyl endopeptidase led to the rapid destruction of the immunodominant epitopes in these peptides. These results suggest a possible enzyme therapy strategy for celiac sprue, for which the only current therapeutic option is strict exclusion of gluten-containing food.

PMID: 12223360

Celiac.com welcomes your comments below (registration is NOT required).












Related Articles



Comments




Rate this article and leave a comment:
Rating: * Poor Excellent
Your Name *: Email (private) *:




In Celiac.com's Forum Now:


This sounds so much like my daughter's behavior before she was diagnosed with Celiac's in 2nd grade. My heart breaks for you...it is not easy. However, if it is the extreme stomach discomfort that is causing her behavior issues, there is a prescription drug for intestinal cramping called Dicyclom...

Yes I know you are correct I just think I'm in denial and that it could lead to worse issues. In my head I keep thinking if I never went to the doctor for the mysterious rash I never would have known I had celiacs to begin with and would still be eating those Foods. Stupid I know I'm just havin...

Oooo if I had "mild celiac" I will admit it -I'm not grabbing for a cc crepe - I'm grabbing a cc gluten-free pizza and gluten-free bagel! All in good sarcasm -my antibodies are still patrolling since 2016 challenge it doesn't even care for the gluten-free baked goods I make here at home. It ...

If you've ever eaten any of the gluten-free foods made by Amy's, then you know their commitment to taste, quality, and solid gluten-free options. Bolstered by their success in the commercial grocery markets, Amy's is moving into fast food. Not just fast food, drive-through fast food. Amy's Drive...

You certainly have the right to choose this if you wish. But consider the idea that one day you might have a significant other, or something else in your life that is worth living for. Perhaps even children! Those extra 15- 30 years of health might be more than welcome to have then. And also real...