No popular authors found.
Ads by Google:

Categories

No categories found.


Get Celiac.com's E-Newsletter





Ads by Google:


Follow / Share


  FOLLOW US:
Twitter Facebook Google Plus Pinterest RSS Podcast Email  Get Email Alerts
SHARE:

Popular Articles

No popular articles found.
Celiac.com Sponsors:

Serologic and Genetic Markers Identify Celiac Disease in First-Degree Relatives of Patients

Dig Dis Sci 1999;44:2344-2349.

Celiac.com 04/10/2000 - Dr. Carme Farre, of Hospital Sant Joan de Deu, in Barcelona, Spain, and his multi-center colleagues, report in the November issue of Digestive Diseases and Sciences that both serologic markers and the human lymphocyte antigen class II extended DQ2 (HLA-DQ2) haplotype are useful markers for screening first-degree relatives of patients with celiac disease for the disorder. These markers are more reliable predictors of celiac disease than other clinical features, which are absent from one third of relatives of people with celiac disease.

Ads by Google:

The researchers examined the usefulness of serologic markers, HLA-DQ2 haplotype, and clinical features common to celiac disease in the diagnosis of the disorder in 675 first-degree relatives of celiac disease patients. The diagnosis was confirmed by intestinal biopsy. Their results showed that 5.5% of the subjects were diagnosed with celiac disease, which is significantly higher than what was observed in the general public in a previous study. Serum IgA-class anti-endomysium antibodies (IgA-AEA) and IgA-class anti-gliadin antibodies (IgA-AGA) were observed in 5.8% and 1.9% of the relatives, respectively.

According to the researchers: Our results show that IgA-AEA is the most useful marker, since all but one IgA-AEA-positive relative showed histological findings of [celiac disease]. Further, the measurement of IgA-AGA would have missed 66% of the affected relatives. The researchers also concluded that the HLA-DQ2 haplotype also appeared to be a more useful indicator to determine which first-degree relatives had an increased genetic susceptibility to celiac disease, because the marker was detected in 93% of first-degree relatives found to have celiac disease, and 18% of those without it. The four most common clinical symptoms for celiac disease, diarrhea, anemia, food intolerance and growth retardation, were not found in one third of the relatives of patients with celiac disease.

The researchers conclude: Although the definitive diagnosis of [celiac disease] relies upon the intestinal biopsy, it should be preceded by a noninvasive, inexpensive and easy-to-perform screening technique. Their findings indicate that using blood serum IgA-AEA measurements is a useful screening tool for noninvasive screening, and HLA-DQ2 assessment may delineate a very high risk population with a particular genetic susceptibility to [celiac disease].

Celiac.com welcomes your comments below (registration is NOT required).












Related Articles



1 Response:

 
Sandra Garren
Rating: ratingfullratingfullratingfullratingfullratingfull Unrated
said this on
11 Dec 2014 6:43:11 AM PDT
My Natropath has told me that I don't have celiac, but that I do have celiac markers. Not sure if this is legit. She says I should be gluten free based on this. I DO have IBS and diverticulosis. Do I really need to be GF?




Rate this article and leave a comment:
Rating: * Poor Excellent
Your Name *: Email (private) *:




In Celiac.com's Forum Now:


Thanks for the reply! I never thought about the damage to my system causing the problem with eating other foods - excellent point. Really gives me a lot to think about. With regard to my boys, don't fret for them =) They both eat two meals outside the house Monday through Friday, and of cour...

Is Aldis gluten-free line safe? I know their items are marked gluten free such as the Gluten-Free brand. I tried calling but there was no phone line. Its so cheap so just wondering if anyone ever has problems with aldis brands. Also what are things you get at aldis

At school I've always used liquitex acrylic. Cleans up with water if you clean it immediately. And yes, paint inside. make sure to share pictures!

If this continues for more than another day or so get to your doctor. Go now if you are showing signs of dehydration. Hospitals are full of nasty bacteria and viruses you need to make sure that you haven't picked up something. I hope this resolves for you soon.

There is special transparent paint that you can get for glass. You should be able to find it in a good craft or hobby store. If you use that the window can be enjoyed from both sides. You could also use acrylic paint. That would not be transparent. I avoid Tempra and poster type paints. Yo...